The Mezu-Ndubuisi Research Group focuses on studying the effects of oxygen on the retina using newborn mice, who at full term birth are at the same developmental stage as premature babies born at 24 to 26 week gestation. Knowing that the retina can be visualized through an optically clear media, we discovered a way of studying ROP in mice without extracting the retina, leading to the development of an in vivo model of oxygen-induced retinopathy (OIR). The Mezu-Ndubuisi Research Group also studies the correlation between the effects of oxidative stress in the retina and other developing organs, like the lung and kidneys, and investigates the signaling mechanisms involved in these complex interactions.
The Mohr Research Group’s primary research goal is to understand the pathogenesis underlying different congenital infection phenotypes. We conduct translational research, applying basic science to clinically oriented studies, with the goal of improving the long-term outcomes of children exposed to viral infections in utero.