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1500 Highland Ave - T505
Madison, WI 53705-9345
Dr. Pelin Cengiz’s research focuses on finding a novel therapy for neonatal encephalopathy subsequent to hypoxia ischemia (HI). She is particularly interested in the role of Na+/H+ exchanger protein isoform 1 in the reactive hippocampal astrocytes following HI. She is working both with in vitro and in vivo models of HI in order to identify the role of this protein and its effects on neuronal degeneration in the hippocampus. Using Vannucci’s neonatal HI model in 9-day-old mice, she has shown neuroprotection at 72 hours after HI by pharmacologically inhibiting this protein. Her goal is to establish the mechanism(s) that leads to hippocampal neuroprotection by characterizing the function of Na+/H+ exchanger protein isoform 1 after HI. Her ultimate goal is to translate these preclinical findings into clinical studies that will benefit patients with neonatal encephalopathy due to HI.
Dr. Cengiz’s clinical duties include serving as an Attending in the PICU and in the Outpatient Sedation Clinic at American Family Children’s Hospital. Abroad, she is an active member of the international health community.
Additional Research Activities
- The neuroprotective role of TrkB activation by 7,8 dihydroxyflavone following hypoxia and ischemia
- The role of NHE-1 in human reactive astrocytes following hypoxia and ischemia