Klein Research Group News

What We Published in April 2020

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1. Ascierto PA, Fox B, Urba W, Anderson AC, Atkins MB, Borden EC, Brahmer J, Butterfield LH, Cesano A, Chen D, de Gruijl T, Dillman RO, Drake CG, Emens LA, Gajewski TF, Gulley JL, Stephen Hodi F, Hwu P, Kaufman D, Kaufman H, Lotze M, McNeel DG, Margolin K, Marincola F, Mastrangelo MJ, Maus MV, Parkinson DR, Romero PJ, Sondel PM, Spranger S, Sznol M, Weiner GJ, Wiggington JM, Weber JS. Insights from immuno-oncology: the Society for Immunotherapy of Cancer Statement on access to IL-6-targeting therapies for COVID-19. J Immunother Cancer. 2020 Apr;8(1). pii: e000878. doi: 10.1136/jitc-2020-000878. No abstract available. PMID: 32300051.

2. Barretto KT, Brockman-Schneider RA, Kuipers I, Basnet S, Bochkov YA, Altman MC, Jarjour NN, Gern JE, Esnault S. Human airway epithelial cells express a functional IL-5 receptor. Allergy. 2020 Apr 4. doi: 10.1111/all.14297. [Epub ahead of print] PubMed PMID: 32246831.

3. Bastos RW, Valero C, Silva LP, Schoen T, Drott M, Brauer V, Silva-Rocha R, Lind A, Steenwyk JL, Rokas A, Rodrigues F, Resendiz-Sharpe A, Lagrou K, Marcet-Houben M, Gabaldón T, McDonnell E, Reid I, Tsang A, Oakley BR, Loures FV, Almeida F, Huttenlocher A, Keller NP, Ries LNA, Goldman GH. Functional Characterization of Clinical Isolates of the Opportunistic Fungal Pathogen Aspergillus nidulans. mSphere. 2020 Apr8;5(2). pii: e00153-20. doi: 10.1128/mSphere.00153-20. PubMed PMID: 32269156; PubMed Central PMCID:PMC7142298.

4. Chan K, Hoon M, Pattnaik BR, Ver Hoeve JN, Wahlgren B, Gloe S, Williams J, Wetherbee B, Kiland JA, Vogel KR, Jansen E, Salomons G, Walters D, Roullet JB, Gibson KM, McLellan GJ. Vigabatrin-Induced Retinal Functional Alterations and Second-Order Neuron Plasticity in C57BL/6J Mice. Invest Ophthalmol Vis Sci. 2020 Feb 7;61(2):17. doi: 10.1167/iovs.61.2.17. PMID: 32053727.

5. Comstock JR, Buhalog B, Peebles JK, Hinshaw MA, Co DO, Arkin LM. Lipoatrophic panniculitis in an adolescent. Pediatr Dermatol. 2020 Mar 20. doi: 10.1111/pde.14127. [Epub ahead of print] PubMed PMID: 32198786.

6. Conway JA, Kharayat P, Sanders RC Jr, Nett S, Weiss SL, Edwards LR, Breuer R, Kirby A, Krawiec C, Page-Goertz C, Polikoff L, Turner DA, Shults J, Giuliano JS Jr, Orioles A, Balkandier S, Emeriaud G, Rehder KJ, Kian Boon JL, Shenoi A, Vanderford P, Nuthall G, Lee A, Zeqo J, Parsons SJ, Furlong-Dillard J, Meyer K, Harwayne-Gidansky I, Jung P, Adu-Darko M, Bysani GK, McCarthy MA, Shlomovich M, Toedt-Pingel I, Branca A, Esperanza MC, Al-Subu AM, Pinto M, Tallent S, Shetty R, Thyagarajan S, Ikeyama T, Tarquinio KM, Skippen P, Kasagi M, Howell JD, Nadkarni VM, Nishisaki A; Ketamine Use for Tracheal Intubation in Critically Ill Children Is Associated With a Lower Occurrence of Adverse Hemodyna [published online ahead of print, 2020 Apr 17]. Crit Care Med. 2020;10.1097/CCM.0000000000004314. doi:10.1097/CCM.0000000000004314.

7. Farrell PM, Rock MJ, Baker MW. The Impact of the CFTR Gene Discovery on Cystic Fibrosis Diagnosis, Counseling, and Preventive Therapy. Genes (Basel). 2020 Apr 8;11(4). doi: 10.3390/genes11040401. Review. PubMed PMID: 32276344.

8. Fujiogi M, Camargo CA Jr, Raita Y, Bochkov YA, Gern JE, Mansbach JM, Piedra PA, Hasegawa K. Association of rhinovirus species with nasopharyngeal metabolome in bronchiolitis infants: A multicenter study. Allergy. 2020 Apr 18. doi:10.1111/all.14326. [Epub ahead of print] PubMed PMID: 32306415.

9. Golenberg N, Squirrell JM, Bennin DA, Rindy J, Pistono PE, Eliceiri KW, Shelef MA, Kang J, Huttenlocher A. Citrullination regulates wound responses and tissue regeneration in zebrafish. J Cell Biol. 2020 Apr 6;219(4). pii:e201908164. doi: 10.1083/jcb.201908164. PubMed PMID: 32328635; PubMed Central PMCID: PMC7147109.

10. Harer MW, Charlton JR, Tipple TE, Reidy KJ. Preterm birth and neonatal acute kidney injury: implications on adolescent and adult outcomes. J Perinatol. 2020 Apr 10;. doi: 10.1038/s41372-020-0656-7. [Epub ahead of print] Review. PMID: 32277164.

11. Horoz ÖÖ, Aslan N, Yildizdaş D, Çoban Y, Sertdemir Y, Al-Subu A. Somatic regional oxygen saturation as an early marker of intra-abdominal hypertension in critically ill children: a pilot study [published online ahead of print, 2020 Feb 25].Turk J Med Sci. 2020;10.3906/sag-1903-201. doi:10.3906/sag-1903-201.

12. Jackson DJ, Busse WW, Bacharier LB, Kattan M, O’Connor GT, Wood RA, Visness CM, Durham SR, Larson D, Esnault S, Ober C, Gergen PJ, Becker P, Togias A, Gern JE, Altman MC. Association of Respiratory Allergy, Asthma and Expression of the SARS-CoV-2 Receptor, ACE2. J Allergy Clin Immunol. 2020 Apr 22. pii: S0091-6749(20)30551-0. doi: 10.1016/j.jaci.2020.04.009. [Epub ahead of print] PubMed PMID: 32333915; PubMed Central PMCID: PMC7175851.

13. Kellom ER, Wolf B, Rice GM, Stepien KE. Reversal of Vision Loss in a 49-Year-Old Man With Progressive Optic Atrophy Due to Profound Biotinidase Deficiency. J Neuroophthalmol.2020 Mar 31. doi: 10.1097/WNO.0000000000000933. [Epub ahead of print]PMID: 32235217DOI:10.1097/WNO.0000000000000933.

14. Kling PJ. Iron Nutrition, Erythrocytes, and Erythropoietin in the NICU: Erythropoietic and Neuroprotective Effects. Neoreviews. 2020 Feb;21(2):e80-e88. doi: 10.1542/neo.21-2-e80. PMID: 32005718.

15. Kohler J, Kelly MM. Addition of Dornase to Intrapleural Fibrinolytic Therapy Is Not Superior to Fibrinolytic Therapy Alone for Otherwise Healthy Children Hospitalized With Empyema. JAMA Pediatr.2020;174(4):323-324. doi:10.1001/jamapediatrics.2019.5910.

16. Kopriva JM, Miller KJ, Legare JM, Noonan KJ. Trevor’s disease of the distal radioulnar joint in achondroplasia. Am J Med Genet A. 2020 Feb29. Doi: 10.1002/ajmg.a.61529.

17. Kwan STC, Kezer CA, Helfrich KK, Saini N, Huebner SM, Flentke GR, Kling PJ, Smith SM. Maternal iron nutriture modulates placental development in a rat model of fetal alcohol spectrum disorder. Alcohol. 2020 May;84:57-66. doi: 10.1016/j.alcohol.2019.11.003. Epub 2019 Nov 14. PMID: 31734307; PMCID: PMC7131893.

18. Lai J, Schnapp BH, Tillman DS, Westergaard M, Hess J, Kraut AS. Use of graded responsibility and common entrustment considerations among United States emergency medicine residency programs. J Educ Eval Health Prof. 2020;17:11. doi: 10.3352/jeehp.2020.17.11. Epub 2020 Apr 20. PMID: 32306707.

19. McAdams RM, Pak D, Lalovic B, Phillips B, Shen DD. Dexmedetomidine Pharmacokinetics in Neonates with Hypoxic-Ischemic Encephalopathy Receiving Hypothermia. Anesthesiol Res Pract. 2020;2020:2582965. doi: 10.1155/2020/2582965. eCollection 2020. PMID: 32158472; PMCID: PMC7060842.

20. Meinen RD, Bauer AS, Devous K, Cowan E. Point-of-care ultrasound use in umbilical line placement: a review. J Perinatol. 2020 Apr;40(4):560-566. doi: 10.1038/s41372-019-0558-8. Epub 2019 Nov 22. Review. PMID: 31758061.

21. Mezu-Ndubuisi OJ, Macke EL, Kalavacherla R, Nwaba AA, Suscha A, Zaitoun IS, Ikeda A, Sheibani N. Long-term evaluation of retinal morphology and function in a mouse model of oxygen-induced retinopathy. Mol Vis. 2020;26:257-276. eCollection 2020. PMID: 32256029; PMCID: PMC7127927.

22. Pampati S, Lowry R, Moreno MA, Rasberry CN, Steiner RJ. Having a Sexual Photo Shared Without Permission and Associated Health Risks: A Snapshot of Nonconsensual Sexting. JAMA Pediatr. 2020 Mar 23;. doi: 10.1001/jamapediatrics.2020.0028. [Epub ahead of print] PubMed PMID: 32202601; PubMed Central PMCID: PMC7091371.

23. Pet GC, Eickhoff JC, McNevin KE, Do J, McAdams RM. Risk factors for peripherally inserted central catheter complications in neonates. J Perinatol. 2020 Apr;40(4):581-588. doi: 10.1038/s41372-019-0575-7. Epub 2020 Jan 7. PMID: 31911643.

24. Sandri BJ, Lubach GR, Lock EF, Georgieff MK, Kling PJ, Coe CL, Rao RB. Early-Life Iron Deficiency and Its Natural Resolution Are Associated with Altered Serum Metabolomic Profiles in Infant Rhesus Monkeys. J Nutr. 2020 Apr 1;150(4):685-693. doi: 10.1093/jn/nxz274. PMID: 31722400; PMCID: PMC7138653.

25. Schauberger E, Biagini Myers JM, He H, Martin LJ, Arshad SH, Kurukulaaratchy R, Khurana Hershey GK. Use of the Pediatric Asthma Risk Score to predict allergic and nonallergicasthma. Ann Allergy Asthma Immunol. 2020 Mar 20. pii: S1081-1206(20)30154-X. doi: 10.1016/j.anai.2020.03.010. [Epub ahead of print]PubMed PMID: 32201305

26. Schmuhl NB, Mooney KE, Zhang X, Cooney LG, Conway JH, LoConte NK. No association between HPV vaccination and infertility in U.S. females 18-33 years old. [published online ahead of print, 2020 Apr 3].Vaccine. 2020;S0264-410X(20)30414-X. doi:10.1016/j.vaccine.2020.03.035.

27. Verboon JM, Mahmut D, Kim AR, Nakamura M, Abdulhay NJ, Nandakumar SK, Gupta N, Akie TE, Geddis AE, Manes B, Kapp ME, Hofmann I, Gabriel SB, Klein DE, Williams DA, Frangoul HA, Parkhurst SM, Crane GM, Cantor AB, Sankaran VG. Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction. J Clin Immunol. 2020 Apr 17. doi: 10.1007/s10875-020-00778-7. [Epub ahead of print]. PMID: 32303876.

28. Von Bergen NH, Anagnostopoulos PV. Commentary: What is invisible to the eye could be seen through the heart: How advancements to the visualization of the conduction tissue can improve surgical and electrophysiology procedures. J Thorac Cardiovasc Surg. 2020 Mar 9;. doi: 10.1016/j.jtcvs.2020.02.091. [Epub ahead of print] PMID: 32279964.

29. Wiesner DL, Merkhofer RM, Ober C, Kujoth GC, Niu M, Keller NP, Gern JE, Brockman-Schneider RA, Evans MD,  Jackson DJ, Warner T, Jarjour NN, Esnault SJ, Feldman MB, Freeman M, Mou H, Vyas JM, Klein BS. Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation. Cell Host Microbe. 2020 Apr 8;27(4):614-628.e6. doi: 10.1016/j.chom.2020.02.006. Epub 2020 Mar 3. PubMed PMID: 32130954.

30. Wooldridge AR, Carayon P, Hoonakker P, Hose B, Eithun B, Brazelton T 3rd, Ross J, Kohler JE, Kelly MM, Dean SM, Rusy D, Gurses AP. Work system barriers and facilitators in inpatient care transitions of pediatric trauma patients. Appl Ergon.2020 May;85:103059. doi: 10.1016/j.apergo.2020.103059. Epub 2020 Feb 12.

Save the Date: Virtual Pediatrics Research Week Begins 5/26/20

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In response to COVID-19, the Department of Pediatrics’ annual Research Week will offer alternative programming to spotlight the scholarly work from its residents, fellows, faculty and staff. Through a mix of livestreamed lectures and interactive sessions, Research Week’s celebration of scholarship will be virtually available to the University of Wisconsin School of Medicine and Public Health community and anyone interested in the latest advances in pediatric research.

Activities for the week include small group sessions with faculty and trainees to discuss research careers and how to turn an idea into a research project, the distinguished Gerard B. Odell Lecture, a Faculty Research Forum, platform presentations, and an online poster session featuring the research of residents, fellows, faculty and staff. New this year, up to 10 hours of continuing medical education (CME) credit can be earned by attending the lectures.  

A brief outline of the week’s activities is below.

Tuesday, May 26, 2020  
Opening Lecture: What Everyone Needs to Know About Quality Improvement, Informatics and Turning an Idea into a Project
8:00-9:00am | Livestreamed via Blackboard Collaborate
1 CME Credit Available*
Presenters: James Gern, MD, Jennifer Rehm, MD, Michael Semanik, MD and Kristin Shadman, MD
Wednesday, May 27, 2020 
Morning Conference Lecture: Research as a Career Choice 
8:00-9:00am | Livestreamed via Blackboard Collaborate
1 CME Credit Available*
Presenter: Anne Marie Singh, MD
Thursday, May 28, 2020  
Gerard B. Odell Lecture and Grand Rounds Presentation
7:30-8:30am | Livestreamed via Blackboard Collaborate
1 CME Credit Available*
Presenter: Katryn Furuya, MD

The Odell Lecture is named for Gerard B. Odell, MD, who directed the Department of Pediatrics’ Division of Gastroenterology and Nutrition from 1976 through 1991. Dr. Odell was internationally recognized for his research in the field of neonatal jaundice and bilirubin metabolism, and was highly influential in improving the quality of care for newborns and children with liver disease. 

The Gerard B. Odell Research Award is given to an assistant or associate professor of pediatrics in recognition of outstanding research accomplishments and demonstrated potential for future contributions. Dr. Pelin Cengiz (Associate Professor (CHS), Division of Critical Care) will be presented with this year’s Gerard B. Odell Research Award.
 
Department of Pediatrics Faculty Research Forum – New!
8:55am-12:00pm | Livestreamed via Blackboard Collaborate
Up to 3 CME Credits Available*
This session will feature ten research vignettes from Department of Pediatrics faculty who were asked to describe one of their favorite projects. Each presentation will last ten minutes and include an additional five minutes for questions and open discussion. The session will be a great opportunity to learn about exciting new developments in child health research.  More details on each presentation will be available on our website. 
 
Academic Research Town Hall
12:00-12:30pm | Livestreamed via Blackboard Collaborate
Drs. Bikash Pattnaik and James Gern will lead a discussion on mechanisms to promote collaborative research.
Friday, May 29, 2020 
Research Week Keynote Lecture: “How I Became Interested in Pediatrics Research” and Platform Presentations
1:00-3:00pm | Livestreamed via Blackboard Collaborate 
Up to 2 CME Credits Available*
The Research Week Keynote Lecture will be presented by Pelin Cengiz, MD. The lecture will be followed by presentations from two residents, two fellows, and two faculty members. The platform presentations were selected by the Research Week Planning Committee.
 
Online Poster Session and Presentations
3:00-5:00pm | Livestreamed via Blackboard Collaborate
Up to 1.5 CME Credits Available*
Research posters will be presented online by residents, fellows, faculty and staff. Starting at 3:30pm, brief presentations by each researcher will be delivered via Blackboard Collaborate.
 
Learn more about Research Week

Bruce Klein, MD, Awarded Grant from Vaxine

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Bruce Klein, MD
Bruce Klein, MD
Bruce Klein, MD

Bruce Klein, MD, was recently awarded a 1-year, $38,500 grant from Vaxine, an Australian biotechnology company focusing on development of innovative vaccine technologies. This objective of this grant, for the project titled, “Developing Advax adjuvanted vaccine formulation against systemic fungi,” will be to formulate Advax (provided by Vaxine) with protective fungal antigens (provided by the Klein lab) to vaccinate against fungal infections and ultimately to translate the formulation to a human vaccine.

What We Published in March 2020

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  1. Coller RJ, Berry JG, Kuo DZ, Kuhlthau K, Chung PJ, Perrin JM, Hoover CG,Warner G, Shelton C, Thompson LR, Garrity B, Stille CJ. Health System Research Priorities for Children and Youth With Special Health Care Needs.Pediatrics.2020 Mar;145(3).doi: 10.1542/peds.2019-0673.Epub 2020 Feb 5.PubMed PMID: 32024751.
  2. Goldberg JL, Navid F, Hank JA, Erbe AK, Santana V, Gan J, de Bie F, Javaid AM, Hoefges A, Merdler M, Carmichael L, Kim K, Bishop MW, Meager MM, Gillies SD, Pandey JP, Sondel PM. Pre-existing antitherapeutic antibodies against the Fc region of the hu14.18K322A mAb are associated with outcome in patients with relapsed neuroblastoma. J Immunother Cancer. 2020 Mar;8(1). pii: e000590. doi: 10.1136/jitc-2020-000590. PMID:32169872
  3. Gusland DY, Livermore AT, Sterkel AK, Nguyen JC, Conway JH. Two Cases Illustrating the Diagnostic Challenge of Pediatric Blastomycosis Presenting as Osteomyelitis. Pediatr Emerg Care. 2020 Mar 19. doi: 10.1097/PEC.0000000000002084. [Epub ahead of print]. PubMed PMID: 32205801.
  4. Jenkins MC, Moreno MA. Vaccination Discussion among Parents on Social Media: A Content Analysis of Comments on Parenting Blogs. J Health Commun. 2020 Mar 10;1-11. doi: 10.1080/10810730.2020.1737761. [Epub ahead of print] PubMed PMID: 32154770.
  5. Kim M, Rao S, Eickhoff JC, DeSantes KB, Capitini CM. A Retrospective Analysis of Antithrombin III Replacement Therapy for the Treatment of Hepatic Sinusoidal Obstruction Syndrome in Children Following Hematopoietic Stem Cell Transplantation. J Pediatr Hematol Oncol. 2020 Mar;42(2):145-148. doi: 10.1097/MPH.0000000000001422. PMID:30676436
  6. McBride JA, Sterkel AK, Matkovic E, Broman AT, Gibbons-Burgener SN, Gauthier GM. Clinical Manifestations and Outcomes in Immunocompetent and Immunocompromised Patients with Blastomycosis. Clin Infect Dis. 2020 Mar 17. Pii : ciaa276. doi: 10.1093/cid/ciaa276. [Epub ahead of print] PubMed PMID : 32179889.
  7. Mohr-Holland E, Reuter A, Furin J, Garcia-Prats A, De Azevedo V, Mudaly V, Kock Y, Trivino-Duran L, Isaakidis P, Hughes J. Injectable-free regimens containing bedaquiline, delamanid, or both for adolescents with rifampicin-resistant tuberculosis in Khayelitsha, South Africa. EClinicalMedicine.2020 Mar;20:100290.doi: 10.1016/j.eclinm.2020.100290.eCollection 2020 Mar.PubMed PMID: 32154506; PubMed Central PMCID: PMC7057194.
  8. Moreno MA, Hoopes AJ. (2019)Technology and Adolescent Health. Elsevier.
  9. Ryan MS, Kind T, Jirasevijinda TJ, Paul CR, Keeley MG, Rocha MEM. Propelling Educational Innovations to Publication in Five Steps. Academic Medicine. 3/3/20. Online ahead of print.doi: 10.1097/ACM.0000000000003275.
  10. Yang RK, Kuznetsov IB, Ranheim EA, Wei JS, Sindiri S, Gryder BE, Gangalapudi V, Song YK, Patel V, Hank JA, Zuleger CL, Erbe AK, Morris ZS, Quale R, Kim K, Albertini MR, Khan J, Sondel PM. Outcome-related signatures identified by Whole Transcriptome Sequencing of Resectable Stage III/IV Melanoma Evaluated After Starting Hu14.18-IL2. Clin Cancer Res. 2020 Mar 9. pii: clincanres.3294.2019. doi: 10.1158/1078-0432.CCR-19-3294. [Epub ahead of print] PMID:32152202

What We Published in February 2020

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The following scholarly articles were published by Department of Pediatrics faculty and staff during February 2020:

  1. Affenzeller S, Wolkenstein K, Frauendorf H, Jackson DJ. Challenging the concept that eumelanin is the polymorphic brown banded pigment in Cepaea nemoralis. Sci Rep. 2020 Feb 12;10(1):2442. doi: 10.1038/s41598-020-59185-y. PubMed PMID: 32051478; PubMed Central PMCID: PMC7016172.
  2. Agache I, Rocha C, Beltran J, Song Y, Posso M, Solà I, Alonso-Coello P, Akdis C, Akdis M, Canonica W, Casale T, Chivato T, Corren J, Del Giacco S, Eiwegger T, Firinu D, Gern JE, Hamelmann E, Hanania N, Mäkelä M, Martín IH, Nair P, O’Mahony L, Papadopoulos NG, Papi A, Park HS, Pérez de Llano L, Quirce S, Sastre J, Shamji M, Schwarze J, Canelo-Aybar C, Palomares O, Jutel M. Efficacy and safety of treatment with biologicals (benralizumab, dupilumab and omalizumab) for severe allergic asthma. Allergy. 2020 Feb 16. doi: 10.1111/all.14235. [Epub ahead of print] PubMed PMID: 32064642.
  3. Allen BJ, Andert B, Botsford J, Budge SL, Rehm JR. At the Margins: Comparing School Experiences of Nonbinary and Binary-identified Transgender Youth. Journal of School Health. Online Feb 27 2020; doi.org/10.1111/josh.12882
  4. Bergroth E, Aakula M, Elenius V, Remes S, Piippo-Savolainen E, Korppi M, Piedra PA, Bochkov YA, Gern JE, Camargo CA Jr, Jartti T. Rhinovirus Type in Severe Bronchiolitis and the Development of Asthma. J Allergy Clin Immunol Pract. 2020 Feb; 8(2):588-595.e4. doi: 10.1016/j.jaip.2019.08.043. Epub 2019 Sep 11. PubMed PMID: 31520837; PubMed Central PMCID: PMC7012669.
  5. Bjugård Nyberg H, Draper HR, Garcia-Prats AJ, Thee S, Bekker A, Zar HJ, Hooker AC, Schaaf HS, McIlleron H, Hesseling AC, Denti P. Population Pharmacokinetics and Dosing of Ethionamide in Children with Tuberculosis. Antimicrob Agents Chemother. 2020 Feb 21; 64(3). doi: 10.1128/AAC.01984-19. Print 2020 Feb 21. PubMed PMID: 31871093.
  6. Blachowicz A, Raffa N, Bok JW, Choera T, Knox B, Lim FY, Huttenlocher A, Wang CCC, Venkateswaran K, Keller NP. Contributions of Spore Secondary Metabolites to UV-C Protection and Virulence Vary in Different Aspergillus fumigatus Strains. mBio. 2020 Feb 18;11(1). pii: e03415-19. doi: 10.1128/mBio.03415-19. PubMed PMID: 32071276; PubMed Central PMCID: PMC7029147.
  7. Coller RJ, Berry JG, Kuo DZ, Kuhlthau K, Chung PJ, Perrin JM, Hoover CG, Warner G, Shelton C, Thompson LR, Garrity B, Stille CJ. Health System Research Priorities for Children and Youth With Special Health Care Needs. Pediatrics. 2020 Feb 5; doi: 10.1542/peds.2019-0673. [Epub ahead of print] PubMed PMID: 32024751.
  8. Crouse HL, Watts J, St Clair NE, Batra M, McGuinness G, Keating EM, Russ CM, Farr KM, Steenhoff AP, Schubert CJ, Leslie LK, Woods SK, Wilson KA, Camp EA, Butteris SM. Global Health Opportunities in Pediatric Fellowships. Pediatrics. 2020 Feb; 145(2). doi: 10.1542/peds.2019-1589. PubMed PMID: 32001489.
  9. d’Ancona G, Kavanagh J, Roxas C, Green L, Fernandes M, Thomson L, Dhariwal J, Nanzer AM, Jackson DJ, Kent BD. Adherence to Inhaled Corticosteroids and Clinical Outcomes in Mepolizumab Therapy for Severe Asthma. Eur Respir J. 2020 Feb 20. pii: 1902259. doi: 10.1183/13993003.02259-2019. [Epub ahead of print] PubMed PMID: 32060061.
  10. Denlinger LC, Heymann P, Lutter R, Gern JE. Exacerbation-Prone Asthma. J Allergy Clin Immunol Pract. 2020 Feb;8(2):474-482. doi: 10.1016/j.jaip.2019.11.009. Epub 2019 Nov 22. PubMed PMID: 31765853; PubMed Central PMCID: PMC6942520.
  11. de Oliveira S, Houseright RA, Korte BG, Huttenlocher A. DnaJ-PKAc fusion induces liver inflammation in a zebrafish model of Fibrolamellar Carcinoma. Dis Model Mech. 2020 Feb 26. pii: dmm.042564. doi: 10.1242/dmm.042564. [Epub ahead of print] PubMed PMID: 32102783.
  12. Hermsen JL, Okorie UC, Srinivasan S, Schreiter NA, Anagnostopoulos PV. A unique indication for the senning procedure: Atrioventricular discordance with ventriculoarterial concordance. J Card Surg. 2020 Feb;35(2):444-446. doi: 10.1111/jocs.14342. Epub 2019 Dec 3. PMID: 31793037.
  13. Hofmann I, Avagyan S, Stetson A, Guo D, Al-Sayegh H, London WB, Lehmann L. Comparison of outcomes of myeloablative allogeneic stem cell transplantation for pediatric patients with bone marrow failure, myelodysplastic syndrome and acute myeloid leukemia with and without germline GATA2 mutations. Biol Blood Marrow Transplant. 2020 Feb 20. pii: S1083-8791(20)30100-2. doi: 10.1016/j.bbmt.2020.02.015. [Epub ahead of print] PubMed PMID: 32088370.
  14. Kohler J, Kelly MM. Addition of Dornase to Intrapleural Fibrinolytic Therapy Is Not Superior to Fibrinolytic Therapy Alone for Otherwise Healthy Children Hospitalized With Empyema. JAMA Pediatr. 2020 Feb 3; doi:10.1001/jamapediatrics.2019.5910. [Epub ahead of print]
  15. Liu Y, Bochkov YA, Eickhoff JC, Hu T, Zumwalde NA, Tan JW, Lopez C, Fichtinger PS, Reddy TR, Overmyer KA, Gumperz JE, Coon J, Mathur SK, Gern JE, Smith JA. Orosomucoid Like 3 (ORMDL3) Supports Rhinovirus Replication in Human Epithelial Cells. Am J Respir Cell Mol Biol. 2020 Feb 20. doi: 10.1165/rcmb.2019-0237OC. [Epub ahead of print] PubMed PMID: 32078788.
  16. Mann EA, Binder AT, Young HN, Moreno MA, Cox ED. Factors associated with health psychology use in pediatric type 1 diabetes. Diabetes Res Clin Pract. 2020 Feb 11; 161:108071. doi: 10.1016/j.diabres.2020.108071. [Epub ahead of print] PubMed PMID: 32057961.
  17. McAdams, RM, Pak D, Lalovic B, Phillips B, Shen, DD. Dexmedetomidine Pharmacokinetics in Neonates with Hypoxic-Ischemic Encephalopathy Receiving Hypothermia. Anesthesiology Research and Practice. 2020 Feb 25; 1687-6970 doi: 10.1155/2020/2582965
  18. McBride JA, Binstadt B, Ahmed R, Baskaya MK, Olson AP, Wald E. A Plea to Reconsider the Diagnosis. J Hosp Med. 2020 Feb 1; 15(2):111-115. doi:10.12788/jhm.3348. Epub 2019 Dec 23. PubMed PMID: 31869290.
  19. Moreno MA, Binger K, Zhao Q, Eickhoff J. Measuring Interests Not Minutes: Development and Validation of the Adolescents’ Digital Technology Interactions and Importance Scale (ADTI). J Med Internet Res. 2020 Feb 12; 22(2):216736.  DOI: 10.2196/16736
  20. Nakagome K, Shimizu T, Bochkov YA, Noguchi T, Kobayashi T, Soma T, Ueki S, Gern JE, Nagata M. Cadherin-related family member 3 upregulates the effector functions of eosinophils. Allergy. 2020 Feb 13. doi: 10.1111/all.14229. [Epub ahead of print] PubMed PMID: 32056219.
  21. St Clair NE, Abdul-Mumin A, Banker SL, Condurache T, Crouse H, Haq H, Helphinstine J, Kazembe PN, Marton S, McQuilkin P, Pitt MB, Rus M, Russ CM, Schubert C, Schutze GE, Steenhoff AP, Uwemedimo O, Watts J, Butteris SM. Global Guide: A Comprehensive Global Health Education Resource for Pediatric Program Directors. Pediatrics. 2020 Feb; 145(2). doi: 10.1542/peds.2019-2138. Epub 2020 Jan 3. Review. PubMed PMID: 31900316.
  22. Theisen E, Lee DE, Pei S, Schauder DM, Chiu YE, Brandling-Bennett H, CurranML, Klein-Gitelman M, Co DO, Arkin LM. Hypergammaglobulinemic purpura of Waldenström in children. Pediatr Dermatol. 2020 Feb 27. doi: 10.1111/pde.14120. [Epub ahead of print] PubMed PMID: 32104943.
  23. Van Swol LM, Chang C, Kerr BR, Moreno MA. Linguistic Predictors of Problematic Drinking in Alcohol-related Facebook Posts. Journal of Health Communication. 2020 February; doi: 10.1080/10810730.2020.1731632.
  24. Webber S, Babal JC, Shadman KA, Coller RJ, Moreno MA. Exploring academic pediatrician perspectives of factors impacting physician well-being. Acad Pediatr. 2020 Feb 22; doi: 10.1016/j.acap.2020.02.018. [Epub ahead of print] PubMed PMID: 32097783.
  25. Wilk MA, Braun AT, Farrell PM, Laxova A, Brown DM, Holt JM, Birch CL, Sosonkina N, Wilk BM, Worthey EA. Applying whole-genome sequencing in relation to phenotype and outcomes in siblings with cystic fibrosis. Cold Spring Harb Mol Case Stud. 2020 Feb;6(1). doi: 10.1101/mcs.a004531. Print 2020 Feb. PMID: 32014855; PMCID: PMC6996517.

Bruce Klein, MD and Marcel Wüethrich, PhD, Awarded Subaward Contract from NIH

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Bruce Klein, MD
Bruce Klein, MD
Bruce Klein, MD

Congratulations to Bruce Klein, MD, Subcontract Principal Investigator, and Marcel Wüethrich, PhD, Co-Investigator, on their new grant subaward through the University of Massachusetts, Worcester and supported by the National Institutes of Health/National Institutes of Allergy and Infectious Diseases (NIH/NIAID). This project, entitled “Identification of human T cell epitopes of pathogenic fungi,” is under the direction of University of Massachusetts overall PI, Stuart Levitz, MD. The subaward to the UW was funded in the amount of $570,554 over 5 years, with the goal to identify CD4+ T cell epitopes from antigens that human patients respond to during infection with pathogenic fungi including Blastomyces dermatitidis, Histoplasma capsulatum, Coccidioides posadasii, and Cryptococcus neoformans.

Bruce Klein, MD, Awarded 2-Year Grant from US Geological Survey

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Bruce Klein, MD
Bruce Klein, MD
Bruce Klein, MD

Congratulations to Bruce Klein, MD, who was recently awarded a 2-year grant for $89,587 from the United States Geological Survey (USGS) for his project entitled, “A bat skin model to identify therapeutic approaches that enhance fungal recognition and augment innate immune response to white-nose syndrome.” The overall goal of this project is to create a bat skin model to elucidate how bat skin cells detect invasive fungi and develop therapeutic approaches that enhance fungal recognition and augment innate immune response to White-Nose Syndrome.

What We Published in January 2020

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The following scholarly articles were published by Department of Pediatrics faculty and staff during January 2020:

  1. Altman MC, Beigelman A, Ciaccio C, Gern JE, Heymann PW, Jackson DJ, Kennedy JL, Kloepfer K, Lemanske RF Jr, McWilliams LM, Muehling L, Nance C, Peebles RS Jr. Evolving Concepts in how Viruses Impact Asthma. J Allergy Clin Immunol. 2020 Jan 8;. doi: 10.1016/j.jaci.2019.12.904. [Epub ahead of print] PMID: 31926183.
  2. Carayon P, Wooldridge A, Hoonakker P, Hundt AS, Kelly MM. SEIPS 3.0: Human-centered design of the patient journey for patient safety. Appl Ergon. 2020 Apr;84:103033. doi: 10.1016/j.apergo.2019.103033. Epub 2020 Jan 10. PubMed PMID: 31987516.
  3. Cash S, Schwab-Reese LM, Zipfel E, Wilt M, Moreno MA. What College Students Post About Depression on Facebook and the Support They Perceive: A Content Analysis. JMIR. 2019. DOI: 10.2196/13650.  (online ahead of print) URL: https://preprints.jmir.org/preprint/13650
  4. Chan K, Sisk B, Yun K, St Clair NE. Global Health Experience and Interest: Results From the AAP Periodic Survey. Pediatrics. 2020 Jan;. doi: 10.1542/peds.2019-1655. Epub 2019 Dec 10. PubMed PMID: 31822511.
  5. Detty SQ, Peebles JK, Guerrieri JM, Seroogy CM, Struck MC, Arkin LM, Henderson SL. Vaccine-Strain Herpes Zoster Ophthalmicus in a 14-month-old Boy Prompting an Immunodeficiency Workup: Case Report and Review of Vaccine-strain Herpes Zoster. Pediatr Infect Dis J. 2020 Feb;39(2):e25-e27. doi: 10.1097/INF.0000000000002545. PMID: 31929435.
  6. Dobson HE, Dias LDS, Kohn EM, Fites S, Wiesner DL, Dileepan T, Kujoth GC, Abraham A, Ostroff GR, Klein BS, Wüthrich M. Antigen discovery unveils resident memory and migratory cell roles in antifungal resistance. Mucosal Immunol. 2020 Jan 3. doi: 10.1038/s41385-019-0244-3. [Epub ahead of print] PubMed PMID: 31900406.
  7. Gupta A, Swindells S, Kim S, Hughes MD, Naini L, Wu X, Dawson R, Mave V, Sanchez J, Mendoza A, Gonzales P, Kumarasamy N, Comins K, Conradie F, Shenje J, Fontain SN, Garcia-Prats A, Asmelash A, Nedsuwan S, Mohapi L, Lalloo UG, Ferreira ACG, Mugah C, Harrington M, Jones L, Cox SR, Smith B, Shah NS, Hesseling AC, Churchyard G. Feasibility of Identifying Household Contacts of Rifampin-and Multidrug-resistant Tuberculosis Cases at High Risk of Progression to Tuberculosis Disease. Clin Infect Dis. 2020 Jan 16;70(3):425-435. doi: 10.1093/cid/ciz235. PubMed PMID: 30942853.
  8. Harer MW, McAdams RM, Conaway M, Vergales BD, Hyatt DM, Charlton JR. Delayed Umbilical Cord Clamping is Not Associated with Acute Kidney Injury in Very Low Birth Weight Neonates. Am J Perinatol. 2020 Jan;37(2):210-215. doi: 10.1055/s-0039-1697671. Epub 2019 Oct 13. PubMed PMID: 31606889.
  9. Paul CR, Moreno MA. Acute Otitis Media. JAMA Pediatr. 2020 January; doi:10.1001/jamapediatrics.2019.5664. (Online ahead of print)
  10. Pet GC, Eickhoff JC, McNevin KE, Do J, McAdams RM. Risk factors for peripherally inserted central catheter complications in neonates. J Perinatol. 2020 Jan 7. doi: 10.1038/s41372-019-0575-7. [Epub ahead of print] PubMed PMID: 31911643.
  11. Rosowski EE, He J, Huisken J, Keller NP, Huttenlocher A. Efficacy of Voriconazole against Aspergillus fumigatus Infection Depends on Host Immune Function. Antimicrob Agents Chemother. 2020 Jan 27;64(2). doi: 10.1128/AAC.00917-19. Print 2020 Jan 27. PMID: 31740552.
  12. St Clair NE, Abdul-Mumin A, Banker SL, Condurache T, Crouse H, Haq H, Helphinstine J, Kazembe PN, Marton S, McQuilkin P, Pitt MB, Rus M, Russ CM, Schubert C, Schutze GE, Steenhoff AP, Uwemedimo O, Watts J, Butteris SM. Global Guide: A Comprehensive Global Health Education Resource for Pediatric Program Directors. Pediatrics. 2020 Jan 3;. doi: 10.1542/peds.2019-2138. [Epub ahead of print] Review. PubMed PMID: 31900316.
  13. Suryavanshi N, Murrill M, Gupta A, Hughes M, Hesseling A, Kim S, Naini L, Jones L, Smith B, Gupte N, Dawson R, Mave V, Meshram S, Mendoza-Ticona A, Sanchez J, Kumarasamy N, Comins K, Conradie F, Shenje J, Nerette Fontain S, Garcia-Prats A, Asmelash A, Nedsuwan S, Mohapi L, Lalloo U, Cristina Garcia Ferreira A, Okeyo E, Swindells S, Churchyard G, Shah NS. Willingness to Take Multidrug-resistant Tuberculosis (MDR-TB) Preventive Therapy Among Adult and Adolescent Household Contacts of MDR-TB Index Cases: An International Multisite Cross-sectional Study. Clin Infect Dis. 2020 Jan 16;70(3):436-445. doi: 10.1093/cid/ciz254. PubMed PMID: 30919881.
  14. Tory H, Zurakowski D, Kim S. Patient and physician discordance of global disease assessment in juvenile dermatomyositis: findings from the Childhood Arthritis & Rheumatology Research Alliance Legacy Registry [Huttenlocher A]. Pediatr Rheumatol Online J. 2020 Jan 15;18(1):5. doi: 10.1186/s12969-020-0402-x. PMID: 31941511; PMCID: PMC6964044.
  15. Tsuchiya N, Schiebler ML, Evans MD, Cadman RV, Sorkness RL, Lemanske RF Jr, Jackson DJ, Jarjour NN, Denlinger LC, Fain SB. Safety of repeated hyperpolarized helium 3 magnetic resonance imaging in pediatric asthma patients. Pediatr Radiol. 2020 Jan 24;. doi: 10.1007/s00247-019-04604-0. [Epub ahead of print] PMID: 31980848.

Bruce Klein, MD, and Marcel Wüethrich, PhD, Awarded NIH R01 Renewal

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Congratulations to Bruce Klein, MD, Principal Investigator, and Marcel Wüethrich, PhD, Multiple PI, on the competitive renewal of their National Institutes of Health/National Institutes of Allergy and Infectious Diseases (NIH/NIAID) R01 grant entitled, “Mechanisms of antifungal vaccine immunity.” This project, which is now entering its 20th year, was funded in the amount of $2.8 million for years 20 through 24. During this 5-year renewal, the team aims to harness a novel antigen to elicit and analyze mechanisms of vaccine immunity against dimorphic fungi.