Jo Wilson receives grant to study Gasdermin B and its role in respiratory epithelial wound healing

Jo WilsonJo Wilson, MD, instructor, Division of Allergy, Immunology and Rheumatology, was recently awarded a grant from the 2023 Opportunity Fund of the NIH-funded Asthma and Allergic Diseases Cooperative Research Centers (U19) Program (AADCRC) for her project, “Investigation of GSDMBs Role in Viral and Mechanical Wound Healing Amongst rs2305480 Genotypes.” This $75,000 award will provide one year of support starting July 1, 2023. Under the mentorship of James Gern, MD, professor and chief, Yury Bochkov, PhD, senior scientist III, and Daniel Jackson MD, professor, all of the Division of Allergy, Immunology and Rheumatology, Wilson will explore the role of gasdermins, specifically GSDMB, in the role of respiratory epithelial wound healing. A single nucleotide polymorphism (SNP) in GSDMB has been determined to lead to higher risk of asthma development and loss of asthma control. The work will focus on GSDMB asthma risk genotypes and the relationship to wound healing phenotypes after mechanical wound and rhinoviral infection.