Pediatrics Research Week 2020 – Abstract Book
Pediatrics Research Week 2020 – Abstract Book
Pediatrics Research Week 2020 - Abstract Book
File: Pediatrics-Research-Week-2020-Abstract-Book-1.pdfPediatrics Research Week 2020 - Abstract Book
File: Pediatrics-Research-Week-2020-Abstract-Book-1.pdfPediatrics Research Week 2020 – Abstract Book
1. Ascierto PA, Fox B, Urba W, Anderson AC, Atkins MB, Borden EC, Brahmer J, Butterfield LH, Cesano A, Chen D, de Gruijl T, Dillman RO, Drake CG, Emens LA, Gajewski TF, Gulley JL, Stephen Hodi F, Hwu P, Kaufman D, Kaufman H, Lotze M, McNeel DG, Margolin K, Marincola F, Mastrangelo MJ, Maus MV, Parkinson DR, Romero PJ, Sondel PM, Spranger S, Sznol M, Weiner GJ, Wiggington JM, Weber JS. Insights from immuno-oncology: the Society for Immunotherapy of Cancer Statement on access to IL-6-targeting therapies for COVID-19. J Immunother Cancer. 2020 Apr;8(1). pii: e000878. doi: 10.1136/jitc-2020-000878. No abstract available. PMID: 32300051.
2. Barretto KT, Brockman-Schneider RA, Kuipers I, Basnet S, Bochkov YA, Altman MC, Jarjour NN, Gern JE, Esnault S. Human airway epithelial cells express a functional IL-5 receptor. Allergy. 2020 Apr 4. doi: 10.1111/all.14297. [Epub ahead of print] PubMed PMID: 32246831.
3. Bastos RW, Valero C, Silva LP, Schoen T, Drott M, Brauer V, Silva-Rocha R, Lind A, Steenwyk JL, Rokas A, Rodrigues F, Resendiz-Sharpe A, Lagrou K, Marcet-Houben M, Gabaldón T, McDonnell E, Reid I, Tsang A, Oakley BR, Loures FV, Almeida F, Huttenlocher A, Keller NP, Ries LNA, Goldman GH. Functional Characterization of Clinical Isolates of the Opportunistic Fungal Pathogen Aspergillus nidulans. mSphere. 2020 Apr8;5(2). pii: e00153-20. doi: 10.1128/mSphere.00153-20. PubMed PMID: 32269156; PubMed Central PMCID:PMC7142298.
4. Chan K, Hoon M, Pattnaik BR, Ver Hoeve JN, Wahlgren B, Gloe S, Williams J, Wetherbee B, Kiland JA, Vogel KR, Jansen E, Salomons G, Walters D, Roullet JB, Gibson KM, McLellan GJ. Vigabatrin-Induced Retinal Functional Alterations and Second-Order Neuron Plasticity in C57BL/6J Mice. Invest Ophthalmol Vis Sci. 2020 Feb 7;61(2):17. doi: 10.1167/iovs.61.2.17. PMID: 32053727.
5. Comstock JR, Buhalog B, Peebles JK, Hinshaw MA, Co DO, Arkin LM. Lipoatrophic panniculitis in an adolescent. Pediatr Dermatol. 2020 Mar 20. doi: 10.1111/pde.14127. [Epub ahead of print] PubMed PMID: 32198786.
6. Conway JA, Kharayat P, Sanders RC Jr, Nett S, Weiss SL, Edwards LR, Breuer R, Kirby A, Krawiec C, Page-Goertz C, Polikoff L, Turner DA, Shults J, Giuliano JS Jr, Orioles A, Balkandier S, Emeriaud G, Rehder KJ, Kian Boon JL, Shenoi A, Vanderford P, Nuthall G, Lee A, Zeqo J, Parsons SJ, Furlong-Dillard J, Meyer K, Harwayne-Gidansky I, Jung P, Adu-Darko M, Bysani GK, McCarthy MA, Shlomovich M, Toedt-Pingel I, Branca A, Esperanza MC, Al-Subu AM, Pinto M, Tallent S, Shetty R, Thyagarajan S, Ikeyama T, Tarquinio KM, Skippen P, Kasagi M, Howell JD, Nadkarni VM, Nishisaki A; Ketamine Use for Tracheal Intubation in Critically Ill Children Is Associated With a Lower Occurrence of Adverse Hemodyna [published online ahead of print, 2020 Apr 17]. Crit Care Med. 2020;10.1097/CCM.0000000000004314. doi:10.1097/CCM.0000000000004314.
7. Farrell PM, Rock MJ, Baker MW. The Impact of the CFTR Gene Discovery on Cystic Fibrosis Diagnosis, Counseling, and Preventive Therapy. Genes (Basel). 2020 Apr 8;11(4). doi: 10.3390/genes11040401. Review. PubMed PMID: 32276344.
8. Fujiogi M, Camargo CA Jr, Raita Y, Bochkov YA, Gern JE, Mansbach JM, Piedra PA, Hasegawa K. Association of rhinovirus species with nasopharyngeal metabolome in bronchiolitis infants: A multicenter study. Allergy. 2020 Apr 18. doi:10.1111/all.14326. [Epub ahead of print] PubMed PMID: 32306415.
9. Golenberg N, Squirrell JM, Bennin DA, Rindy J, Pistono PE, Eliceiri KW, Shelef MA, Kang J, Huttenlocher A. Citrullination regulates wound responses and tissue regeneration in zebrafish. J Cell Biol. 2020 Apr 6;219(4). pii:e201908164. doi: 10.1083/jcb.201908164. PubMed PMID: 32328635; PubMed Central PMCID: PMC7147109.
10. Harer MW, Charlton JR, Tipple TE, Reidy KJ. Preterm birth and neonatal acute kidney injury: implications on adolescent and adult outcomes. J Perinatol. 2020 Apr 10;. doi: 10.1038/s41372-020-0656-7. [Epub ahead of print] Review. PMID: 32277164.
11. Horoz ÖÖ, Aslan N, Yildizdaş D, Çoban Y, Sertdemir Y, Al-Subu A. Somatic regional oxygen saturation as an early marker of intra-abdominal hypertension in critically ill children: a pilot study [published online ahead of print, 2020 Feb 25].Turk J Med Sci. 2020;10.3906/sag-1903-201. doi:10.3906/sag-1903-201.
12. Jackson DJ, Busse WW, Bacharier LB, Kattan M, O’Connor GT, Wood RA, Visness CM, Durham SR, Larson D, Esnault S, Ober C, Gergen PJ, Becker P, Togias A, Gern JE, Altman MC. Association of Respiratory Allergy, Asthma and Expression of the SARS-CoV-2 Receptor, ACE2. J Allergy Clin Immunol. 2020 Apr 22. pii: S0091-6749(20)30551-0. doi: 10.1016/j.jaci.2020.04.009. [Epub ahead of print] PubMed PMID: 32333915; PubMed Central PMCID: PMC7175851.
13. Kellom ER, Wolf B, Rice GM, Stepien KE. Reversal of Vision Loss in a 49-Year-Old Man With Progressive Optic Atrophy Due to Profound Biotinidase Deficiency. J Neuroophthalmol.2020 Mar 31. doi: 10.1097/WNO.0000000000000933. [Epub ahead of print]PMID: 32235217DOI:10.1097/WNO.0000000000000933.
14. Kling PJ. Iron Nutrition, Erythrocytes, and Erythropoietin in the NICU: Erythropoietic and Neuroprotective Effects. Neoreviews. 2020 Feb;21(2):e80-e88. doi: 10.1542/neo.21-2-e80. PMID: 32005718.
15. Kohler J, Kelly MM. Addition of Dornase to Intrapleural Fibrinolytic Therapy Is Not Superior to Fibrinolytic Therapy Alone for Otherwise Healthy Children Hospitalized With Empyema. JAMA Pediatr.2020;174(4):323-324. doi:10.1001/jamapediatrics.2019.5910.
16. Kopriva JM, Miller KJ, Legare JM, Noonan KJ. Trevor’s disease of the distal radioulnar joint in achondroplasia. Am J Med Genet A. 2020 Feb29. Doi: 10.1002/ajmg.a.61529.
17. Kwan STC, Kezer CA, Helfrich KK, Saini N, Huebner SM, Flentke GR, Kling PJ, Smith SM. Maternal iron nutriture modulates placental development in a rat model of fetal alcohol spectrum disorder. Alcohol. 2020 May;84:57-66. doi: 10.1016/j.alcohol.2019.11.003. Epub 2019 Nov 14. PMID: 31734307; PMCID: PMC7131893.
18. Lai J, Schnapp BH, Tillman DS, Westergaard M, Hess J, Kraut AS. Use of graded responsibility and common entrustment considerations among United States emergency medicine residency programs. J Educ Eval Health Prof. 2020;17:11. doi: 10.3352/jeehp.2020.17.11. Epub 2020 Apr 20. PMID: 32306707.
19. McAdams RM, Pak D, Lalovic B, Phillips B, Shen DD. Dexmedetomidine Pharmacokinetics in Neonates with Hypoxic-Ischemic Encephalopathy Receiving Hypothermia. Anesthesiol Res Pract. 2020;2020:2582965. doi: 10.1155/2020/2582965. eCollection 2020. PMID: 32158472; PMCID: PMC7060842.
20. Meinen RD, Bauer AS, Devous K, Cowan E. Point-of-care ultrasound use in umbilical line placement: a review. J Perinatol. 2020 Apr;40(4):560-566. doi: 10.1038/s41372-019-0558-8. Epub 2019 Nov 22. Review. PMID: 31758061.
21. Mezu-Ndubuisi OJ, Macke EL, Kalavacherla R, Nwaba AA, Suscha A, Zaitoun IS, Ikeda A, Sheibani N. Long-term evaluation of retinal morphology and function in a mouse model of oxygen-induced retinopathy. Mol Vis. 2020;26:257-276. eCollection 2020. PMID: 32256029; PMCID: PMC7127927.
22. Pampati S, Lowry R, Moreno MA, Rasberry CN, Steiner RJ. Having a Sexual Photo Shared Without Permission and Associated Health Risks: A Snapshot of Nonconsensual Sexting. JAMA Pediatr. 2020 Mar 23;. doi: 10.1001/jamapediatrics.2020.0028. [Epub ahead of print] PubMed PMID: 32202601; PubMed Central PMCID: PMC7091371.
23. Pet GC, Eickhoff JC, McNevin KE, Do J, McAdams RM. Risk factors for peripherally inserted central catheter complications in neonates. J Perinatol. 2020 Apr;40(4):581-588. doi: 10.1038/s41372-019-0575-7. Epub 2020 Jan 7. PMID: 31911643.
24. Sandri BJ, Lubach GR, Lock EF, Georgieff MK, Kling PJ, Coe CL, Rao RB. Early-Life Iron Deficiency and Its Natural Resolution Are Associated with Altered Serum Metabolomic Profiles in Infant Rhesus Monkeys. J Nutr. 2020 Apr 1;150(4):685-693. doi: 10.1093/jn/nxz274. PMID: 31722400; PMCID: PMC7138653.
25. Schauberger E, Biagini Myers JM, He H, Martin LJ, Arshad SH, Kurukulaaratchy R, Khurana Hershey GK. Use of the Pediatric Asthma Risk Score to predict allergic and nonallergicasthma. Ann Allergy Asthma Immunol. 2020 Mar 20. pii: S1081-1206(20)30154-X. doi: 10.1016/j.anai.2020.03.010. [Epub ahead of print]PubMed PMID: 32201305
26. Schmuhl NB, Mooney KE, Zhang X, Cooney LG, Conway JH, LoConte NK. No association between HPV vaccination and infertility in U.S. females 18-33 years old. [published online ahead of print, 2020 Apr 3].Vaccine. 2020;S0264-410X(20)30414-X. doi:10.1016/j.vaccine.2020.03.035.
27. Verboon JM, Mahmut D, Kim AR, Nakamura M, Abdulhay NJ, Nandakumar SK, Gupta N, Akie TE, Geddis AE, Manes B, Kapp ME, Hofmann I, Gabriel SB, Klein DE, Williams DA, Frangoul HA, Parkhurst SM, Crane GM, Cantor AB, Sankaran VG. Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction. J Clin Immunol. 2020 Apr 17. doi: 10.1007/s10875-020-00778-7. [Epub ahead of print]. PMID: 32303876.
28. Von Bergen NH, Anagnostopoulos PV. Commentary: What is invisible to the eye could be seen through the heart: How advancements to the visualization of the conduction tissue can improve surgical and electrophysiology procedures. J Thorac Cardiovasc Surg. 2020 Mar 9;. doi: 10.1016/j.jtcvs.2020.02.091. [Epub ahead of print] PMID: 32279964.
29. Wiesner DL, Merkhofer RM, Ober C, Kujoth GC, Niu M, Keller NP, Gern JE, Brockman-Schneider RA, Evans MD, Jackson DJ, Warner T, Jarjour NN, Esnault SJ, Feldman MB, Freeman M, Mou H, Vyas JM, Klein BS. Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation. Cell Host Microbe. 2020 Apr 8;27(4):614-628.e6. doi: 10.1016/j.chom.2020.02.006. Epub 2020 Mar 3. PubMed PMID: 32130954.
30. Wooldridge AR, Carayon P, Hoonakker P, Hose B, Eithun B, Brazelton T 3rd, Ross J, Kohler JE, Kelly MM, Dean SM, Rusy D, Gurses AP. Work system barriers and facilitators in inpatient care transitions of pediatric trauma patients. Appl Ergon.2020 May;85:103059. doi: 10.1016/j.apergo.2020.103059. Epub 2020 Feb 12.
In response to COVID-19, the Department of Pediatrics’ annual Research Week will offer alternative programming to spotlight the scholarly work from its residents, fellows, faculty and staff. Through a mix of livestreamed lectures and interactive sessions, Research Week’s celebration of scholarship will be virtually available to the University of Wisconsin School of Medicine and Public Health community and anyone interested in the latest advances in pediatric research.
Activities for the week include small group sessions with faculty and trainees to discuss research careers and how to turn an idea into a research project, the distinguished Gerard B. Odell Lecture, a Faculty Research Forum, platform presentations, and an online poster session featuring the research of residents, fellows, faculty and staff. New this year, up to 10 hours of continuing medical education (CME) credit can be earned by attending the lectures.
A brief outline of the week’s activities is below.
Tuesday, May 26, 2020 Opening Lecture: What Everyone Needs to Know About Quality Improvement, Informatics and Turning an Idea into a Project 8:00-9:00am | Livestreamed via Blackboard Collaborate 1 CME Credit Available* Presenters: James Gern, MD, Jennifer Rehm, MD, Michael Semanik, MD and Kristin Shadman, MD |
Wednesday, May 27, 2020 Morning Conference Lecture: Research as a Career Choice 8:00-9:00am | Livestreamed via Blackboard Collaborate 1 CME Credit Available* Presenter: Anne Marie Singh, MD |
Thursday, May 28, 2020 Gerard B. Odell Lecture and Grand Rounds Presentation 7:30-8:30am | Livestreamed via Blackboard Collaborate 1 CME Credit Available* Presenter: Katryn Furuya, MD The Odell Lecture is named for Gerard B. Odell, MD, who directed the Department of Pediatrics’ Division of Gastroenterology and Nutrition from 1976 through 1991. Dr. Odell was internationally recognized for his research in the field of neonatal jaundice and bilirubin metabolism, and was highly influential in improving the quality of care for newborns and children with liver disease. The Gerard B. Odell Research Award is given to an assistant or associate professor of pediatrics in recognition of outstanding research accomplishments and demonstrated potential for future contributions. Dr. Pelin Cengiz (Associate Professor (CHS), Division of Critical Care) will be presented with this year’s Gerard B. Odell Research Award. Department of Pediatrics Faculty Research Forum – New! 8:55am-12:00pm | Livestreamed via Blackboard Collaborate Up to 3 CME Credits Available* This session will feature ten research vignettes from Department of Pediatrics faculty who were asked to describe one of their favorite projects. Each presentation will last ten minutes and include an additional five minutes for questions and open discussion. The session will be a great opportunity to learn about exciting new developments in child health research. More details on each presentation will be available on our website. Academic Research Town Hall 12:00-12:30pm | Livestreamed via Blackboard Collaborate Drs. Bikash Pattnaik and James Gern will lead a discussion on mechanisms to promote collaborative research. |
Friday, May 29, 2020 Research Week Keynote Lecture: “How I Became Interested in Pediatrics Research” and Platform Presentations 1:00-3:00pm | Livestreamed via Blackboard Collaborate Up to 2 CME Credits Available* The Research Week Keynote Lecture will be presented by Pelin Cengiz, MD. The lecture will be followed by presentations from two residents, two fellows, and two faculty members. The platform presentations were selected by the Research Week Planning Committee. Online Poster Session and Presentations 3:00-5:00pm | Livestreamed via Blackboard Collaborate Up to 1.5 CME Credits Available* Research posters will be presented online by residents, fellows, faculty and staff. Starting at 3:30pm, brief presentations by each researcher will be delivered via Blackboard Collaborate. |
The following scholarly articles were published by Department of Pediatrics faculty and staff during February 2020:
Congratulations to the following undergraduate students on their receipt of a UW Sophomore Research Fellowship. Each student will receive $2,500 in unrestricted funding and $500 is awarded to the faculty advisor to cover research expenses related to the project.
For more information on the application process: https://awards.advising.wisc.edu/all-scholarships/sophomore-research-fellowship/
A research team led by Bikash Pattnaik, PhD (Assistant Professor, Division of Neonatology and Newborn Nursery and Department of Ophthalmology and Visual Sciences; Investigator, McPherson Eye Research Institute) has shown that two novel approaches to treating an inherited eye disease were effective in restoring the function of a vital component of healthy vision.
The study, published in the January 24, 2019, issue of the American Journal of Human Genetics, concerns a disease called Leber Congenital Amaurosis (LCA16), an eye disorder that affects the retina and causes severe visual damage that typically results in childhood blindness. LCA affects two to three children per 100,000. It can result from mutations in more than 20 genes that are expressed in certain retinal cells – specifically, photoreceptors (cells that are photosensitive and react to lightwaves) and retinal pigment epithelium (RPE), a layer of cells that lies just underneath the photoreceptors.
One such gene, known as KCNJ13, is responsible for producing a protein that is a potassium ion channel in the retina. If the KCNJ13 gene is mutated, it cannot produce the protein correctly; consequently, the vital ion channel, which lets potassium ions pass to and out of the cell, does not function properly. And if the channel does not work properly, the photoreceptor cells cannot encode visual stimuli. The result is a gradual progression toward blindness.
The team first created a “disease in the dish” model to test two possible approaches to treating blindness that results from mutations in the KCNJ13 gene. First, they removed skin cells from two people in the same family. One member had been diagnosed with LCA and had two copies of the mutated gene; the other had no symptoms and had only one copy of the mutation. The skin cells were “re-engineered” back to an undifferentiated state and were analyzed. Both types of cells appeared normal in structure.
But, when they matured, the cells from the LCA-affected person lacked the expression of the protein needed for the ion channel to develop and function. The major disease-causing change affecting the retinal pigment epithelium was the lack of this functional channel. The researchers now had a working model of the “disease in a dish.” The cells could not perform one of the key functions of the retinal pigment epithelium.
The team then tried to “rescue” the deficient ion channel through an approach known as “readthrough therapy.” The mutated gene contained instructions that short-circuit the process of translating DNA into a protein. The resulting protein is thus shorter than it should be. The “readthrough therapy” in this case used an antibiotic (modified) to suppress the signal that stops DNA translation.
While only a portion of the cells completely recovered, the finding suggests that the approach shows promise for future treatment.
In addition, the team used gene therapy in the cells to try to re-establish a proper ion channel. They used lentiviruses – a type of virus with a long incubation period – to deliver corrective genetic information to the affected cells. The result was a functioning potassium current and a normal membrane potential – meaning that ions could move in to and out of the cell correctly.
“We have shown in a cell model that both treatments can restore the retinal cells to proper function,” said Dr. Pattnaik. “This is an important proof of concept for these approaches and gives us hope for the value of precision medicine for pediatric blindness.”
The research was supported by the University of Wisconsin Foundation, the National Eye Institute, the UW Vision Core Grant and the Retina Research Foundation M.D. Mathews Professorship.
Bikash Pattnaik, PhD, was recently awarded a 2-year research grant of $250,000 from Ateres Avigail in support of his project, “Restoration of potassium channel function using mouse models of Lebers Congenital Amaurosis (LCA16) as a means to treat retinal channelopathies.” This project will use mouse models to deliver lentiviral and adenoviral gene-therapy during early, middle and late stages of development targeted to retina pigment epithelium (RPE) apical processes. This study is the first of several steps aimed at developing preventative approaches to treat blindness in LCA16 and testing the role of precision medicine therapeutics.
Congratulations to Katie Beverley, Graduate Research Assistant in the lab of Bikash Pattnaik, PhD, who was recently selected as a Trainee on the National Institutes of Health-funded T32 Endocrinology & Reproductive Physiology (ERP) Training Grant, directed by Ian Bird, PhD. The Endocrinology & Reproductive Physiology Program at the University of Wisconsin is a broad based, interdepartmental degree-granting program designed to provide training at the predoctoral and postdoctoral level in interdisciplinary research at the forefront of Endocrinology and reproductive physiology.
Krishanu Saha, PhD (Biomedical Engineering), will lead a team of investigators, including Co-PIs Shaoqin Sarah Gong, PhD (Biomedical Engineering), Bikash Pattnaik, PhD, and David Gamm, MD, PhD (Ophthalmology and Visual Sciences), and other collaborators, to study genetic disorders of the eye, in their recently awarded UW2020 grant entitled, “Gene Editing Nanomedicines to Correct Pathogenic Mutations in Retinal Pigmented Epithelium.” This 2-year WARF Discovery Initiative project will use advances in biomaterials to generate nonviral, synthetic nanocarriers of CRISPR-Cas9 gene editing machinery for targeted delivery to the retinal pigmented epithelium (RPE) that surrounds the retina. Such research would generally expand the types of tissues that could be edited and hence the spectrum of disease where genomic medicine could have an impact. Support for this research was provided by the University of Wisconsin – Madison Office of the Vice Chancellor for Research and Graduate Education with funding from the Wisconsin Alumni Research Foundation. More about the award can be found here: https://research.wisc.edu/funding/uw2020/round-4-projects/gene-editing-nanomedicines-mutations-retinal-pigmented-epithelium/