Principal Investigator Amy Peterson, MD, associate professor, Cardiology, along with Co-Investigators, Patrice Held, PhD, FACMG, associate professor, Genetics and Metabolism, Vanessa Horner, PhD, Department of Pathology and Laboratory Medicine, and Michael Lasarev, MS, Department of Biostatistics and Medical Informatics, were awarded $427,542 from the National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD) for their project, “Biochemical and molecular newborn screening for familial hypercholesterolemia.” In this study, biochemical and molecular genetic tests will be performed on dried blood spots from Wisconsin newborn screening specimens to design a testing algorithm that can be used to detect familial hypercholesterolemia in the newborn population. With current estimated detection rates at less than 10%, diagnosing individuals in the newborn period has the potential to significantly decrease the burden of heart disease not only to the children identified, but also to their relatives.