Our lab’s research goals have been to investigate the developmental and nutritional regulation of red blood cell production. This research is important because anemia complicates the clinical care of nearly 30,000 premature neonates in the US annually and effective strategies for combating anemia must be developed. Ill premature neonates develop severe anemia, requiring multiple red blood cell transfusions. Erythropoietin, the primary endocrine hormone stimulating red blood cell production, is deficient in premature neonates. The drug, erythropoietin, although effective in adult patients, is less so in premature neonates. Our research seeks to determine why erythropoietin therapy is so ineffective in premature infants.
Our research approach is three-pronged:
- First, we are investigating the interactions of iron and erythropoietin in at-risk neonatal and infant erythropoiesis. Delivery of sufficient iron is critical to red blood cell production. Unlike other patient populations, in early infancy, no marker of poor iron delivery exists and we are examining several options. We are studying the biomarkers to identify those with low iron status.
- Second, we are studying the non-erythropoietic effects of iron deficiency because iron is critical to all organ development. We are studying both brain and kidney development.
- Third, we are investigating the non-traditional roles of erythropoietin. Erythropoietin is an iron-regulated protein, including in early development. In early development, we are exploring whether erythropoietin’s erythropoietic role is relatively less important than its other roles. Because erythropoietin exerts local effects, we are examining the effects of erythropoietin in other tissues (e.g. intestine and brain).
The Midwest Society for Pediatric Research (MSPR) held its annual meeting at Lurie Children’s Hospital last week and the UW-Madison Department of Pediatrics was well represented. Members from all levels of the UW-Madison Department of …October 30, 2019
Dr. Pamela Kling Receives Midwest Society for Pediatric Research’s (MSPR) 2019 Founder’s Award for Outstanding Service to Pediatric Research
Congratulations to Pamela Kling, MD, on being the recipient of the Midwest Society for Pediatric Research’s (MSPR) 2019 Founder’s Award for Outstanding Service to Pediatric Research. The award recognizes her contributions in fostering advances in …October 28, 2019
The following students and their mentors were recently awarded Shapiro Summer Research Awards. The Shapiro Summer Research Program provides opportunities for first-year medical students to participate in eight- to 12-week summer research projects with UW-Madison …May 1, 2019
Congrats to the following faculty on their recent awards from the UnityPoint Health Meriter Foundation: Elizabeth Goetz, MD, and Dinushan Kaluarachchi, MD, received $27,046 for their project, “Oxygen saturation profiles in healthy term neonates.” The …November 1, 2018
Congratulations to the following undergraduate students and their Pediatric mentors who were awarded 2018-2019 Hilldale Undergraduate/Faculty Research Fellowships from the University of Wisconsin. Students receive a stipend of $3,000 and the associated faculty mentor receives …July 1, 2018
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