Otto Kletzien, PhD
Position title: Scientist I
Email: okletzien@pediatrics.wisc.edu
Address:
Division of Hematology, Oncology and Bone Marrow Transplant
Education
BS, University of Wisconsin–Madison, Madison, Wisconsin
PhD, University of Colorado-Boulder, Boulder, Colorado
Postdoctoral Fellowship, McGill University, Montreal, Canada
Professional Activities
Dr. Otto Kletzien is scientist I in the Division of Hematology, Oncology and Bone Marrow Transplant. Kletzien works under Rebecca Richards, MD, PhD, to help develop CAR-T therapies for Acute Myeloid Leukemia. He is currently working to design, optimize, and characterize NOT-Gated CARs through multiple cell-based assays, as well as additional in vivo studies of CAR-T efficacy. Kletzien’s previous research focused on in vitro characterization of RNA-binding proteins. He is excited to apply my biochemistry skillset toward generating stronger CAR-T therapies.
Research Interests
Kletzien is interested in optimizing NOT-gated CAR-T therapies that kill tumor cells while sparing bystander cells. He is also interested in probing the cytokine milieu of CAR-AML interactions and identifying potential secreted factors that inhibit CAR-T activity.