Grant Support

Current Grant Support

NIH/NHLBI (R01 HL139883), “Mechanism of Regulation of Cardiac Contraction by Phosphorylation of Myosin Binding Protein C” (2018-2022). Ralphe, PI

NIH/NHLBI (R01 HL096971), “Top-down proteomics of myofilaments in heart failure” (2017-2021). Ralphe, Co-Investigator

Completed Grant Support

UW Office of VCRGE, “Human engineered cardiac tissue modeling of familial hypertrophic cardiomyopathy” (2018-2019). Ralphe, PI

NIH/NHLBI (F31 HL131230), “The role of the C3 domain of myosin binding protein-C in the pathogenesis of hypertrophic cardiomyopathy” (2016-2018). Ralphe, Mentor; Smelter, Pre-doctoral fellow

NIH/NHLBI (R01 HL107367), “Murine 3D engineered tissue model of human MYBPC3 mutations” (2011-2017). Ralphe, PI

Children’s Cardiomyopathy Foundation, “Human iPS cells and ECT in the study of hypertrophic cardiomyopathy” (2013). Ralphe, PI

American Heart Association (Post-doctoral Fellowship), “POSH and hypertrophic cardiomyopathy: bridging the gap between genetic mutation and hypertrophy” (2012-2013). Ralphe, Mentor

Children’s Cardiomyopathy Foundation, “3D engineered tissue model of MYBPC3 mutations: a novel tool to unravel genotype/phenotype relationships in childhood hypertrophic cardiomyopathy” (2010). Ralphe, PI

NIH/NHLBI (K08 HL074224), “Expression and function of EAATs in the heart” (2005-2010).

American Heart Association (Beginning Grant-in-Aid), “Mitochondrial maturation and function in the engineered heart model” (2007-2009).

Brystol-Myers Squibb, “A Phase III open label non randomized international multicenter trial to evaluate the efficacy and safety of Cardiolite myocardial perfusion imaging in pediatric subjects with Kawasaki’s disease” (2006-2007). Ralphe, PI

Children’s Miracle Network, “Expression and function of the excitatory amino acid transporters in the heart” (2003-2004). Ralphe, PI

Children’s Miracle Network, “Importance of the aspartate/glutamate carrier in perinatal heart” (2001-2003). Ralphe, PI

NIH/NRSA (T32 HL007413), “Research training program in pediatric cardiology” (2000-2002). Ralphe, Post-doctoral Trainee