Our group focuses on using preclinical models of allogeneic blood and marrow transplant (alloBMT) to cure pediatric cancers. The goal of this research is two-fold: (1) to improve graft-versus-tumor (GVT) effects using adoptive cellular therapies, like T cell and natural killer (NK) cell infusions, and antibody-based approaches that have potential to be translated into the clinic; (2) to reduce or eliminate graft-versus-host-disease (GVHD) through modulation of antigen presenting cells.
One component of the Immunotherapy & Hematopoietic Stem Cell Transplant Research Group is exploring methods to improve the GVT effect. T cells can recognize tumors as foreign, treating any evidence of relapsed disease. Dr. Capitini is a site investigator for clinical trials studying a chimeric antigen receptor (CAR)-modified T cell for relapsed leukemia.
There are other populations of lymphocytes that also contribute to the GVT effect, such as NK cells. Ongoing work is combining NK cells expanded with costimulatory molecules and gamma (c) cytokines with antibodies to stimulate NK cell proliferation and activation against several pediatric tumors in the alloBMT setting. We are also developing imaging techniques to monitor NK cell trafficking in vivo.
All of the potential benefits of using alloBMT to treat cancer comes with the potential of inducing GVHD, which is caused by donor T cells attacking normal host tissues such as the liver, skin or gut. Dr. Capitini has previously demonstrated that even subclinical GVHD can have deleterious effects on the efficacy of tumor vaccines as well as promote tumor growth. He also showed a novel approach of modulating GVHD through usage of T cell depleted bone marrow deficient in gamma interferon receptor signaling. By using this platform, he has identified a molecule called STAT1, which is downstream of the gamma interferon receptor, plays a critical role in regulating plasmacytoid dendritic cells (pDCs) and GVHD. Ongoing work is exploring the impact of pDCs and other antigen presenting cells on GVHD.
Tumor Vaccines After Allogeneic Hematopoietic Stem Cell Transplantation – A Lost Hope?
UW Pediatrics Grand Rounds – Christian M. Capitini, MD
Additional Research Activities
- Basic, translational and clinical research of pediatric cancers
- Adoptive cell therapies (NK cell and CAR T cell infusions)
- Models of bone marrow transplant
- Cancer vaccines
- Antigen presenting cells
Research Opportunities – Graduate Students
For students interested in obtaining a PhD, Dr. Capitini is a trainer for the Cellular and Molecular Pathology (CMP), Cellular and Molecular Biology (CMB), Clinical Investigation (ICTR), and Comparative Biomedical Sciences (CBMS) Graduate Programs. For more information, please click on the link for each program above.
Research Opportunities – Postdoctoral Fellows
Interested applicants with experience in cellular immunology, tumor models and/or molecular genetics may send a cover letter, CV, and emails for 3 references to email@example.com for consideration.
This is an accordion element with a series of buttons that open and close related content panels.
1. Ascierto PA, Fox B, Urba W, Anderson AC, Atkins MB, Borden EC, Brahmer J, Butterfield LH, Cesano A, Chen D, de Gruijl T, Dillman RO, Drake CG, Emens LA, Gajewski TF, Gulley JL, Stephen …June 4, 2020
Congratulations to UW undergraduate student David Turicek, who was awarded a Welton Summer Sophomore Honors Apprenticeship for the project, “Treating post-transplant B-cell acute lymphoblastic leukemia with blinatumomab as a radiation sparing immunotherapy.” This project will …June 1, 2020
Congratulations to Fernanda Szewc, graduate research assistant in the Capitini Laboratory, who was recently appointed to the TL1 Clinical Investigation program supported by the UW Institute for Clinical and Translational Research (ICTR). This two-year award …June 1, 2020
Congratulations to Aicha Quamine, Hematology/Oncology & Bone Marrow Transplant Graduate Student in the Capitini Laboratory, who was recently awarded a 2020 National Science Foundation (NSF) Graduate Research Fellowship (GRF) for her project “Bioengineering and Characterization …June 1, 2020
The Pediatrics Research Week 2020 Abstract Book is now available. University of Wisconsin Department of Pediatrics faculty, staff, fellows and residents submitted over 50 research abstracts for the virtual conference, which is taking place May 26-29, 2020. …May 21, 2020
- More News...