Our group focuses on using preclinical models of allogeneic blood and marrow transplant (alloBMT) to cure pediatric cancers. The goal of this research is two-fold: (1) to improve graft-versus-tumor (GVT) effects using adoptive cellular therapies, like T cell and natural killer (NK) cell infusions, and antibody-based approaches that have potential to be translated into the clinic; (2) to reduce or eliminate graft-versus-host-disease (GVHD) through modulation of antigen presenting cells.
One component of the Immunotherapy & Hematopoietic Stem Cell Transplant Research Group is exploring methods to improve the GVT effect. T cells can recognize tumors as foreign, treating any evidence of relapsed disease. Dr. Capitini is a site investigator for clinical trials studying a chimeric antigen receptor (CAR)-modified T cell for relapsed leukemia.
There are other populations of lymphocytes that also contribute to the GVT effect, such as NK cells. Ongoing work is combining NK cells expanded with costimulatory molecules and gamma (c) cytokines with antibodies to stimulate NK cell proliferation and activation against several pediatric tumors in the alloBMT setting. We are also developing imaging techniques to monitor NK cell trafficking in vivo.
All of the potential benefits of using alloBMT to treat cancer comes with the potential of inducing GVHD, which is caused by donor T cells attacking normal host tissues such as the liver, skin or gut. Dr. Capitini has previously demonstrated that even subclinical GVHD can have deleterious effects on the efficacy of tumor vaccines as well as promote tumor growth. He also showed a novel approach of modulating GVHD through usage of T cell depleted bone marrow deficient in gamma interferon receptor signaling. By using this platform, he has identified a molecule called STAT1, which is downstream of the gamma interferon receptor, plays a critical role in regulating plasmacytoid dendritic cells (pDCs) and GVHD. Ongoing work is exploring the impact of pDCs and other antigen presenting cells on GVHD.
Tumor Vaccines After Allogeneic Hematopoietic Stem Cell Transplantation – A Lost Hope?
UW Pediatrics Grand Rounds – Christian M. Capitini, MD
Additional Research Activities
- Basic, translational and clinical research of pediatric cancers
- Adoptive cell therapies (NK cell and CAR T cell infusions)
- Models of bone marrow transplant
- Cancer vaccines
- Antigen presenting cells
Research Opportunities – Graduate Students
For students interested in obtaining a PhD, Dr. Capitini is a trainer for the Cellular and Molecular Pathology (CMP), Cellular and Molecular Biology (CMB), Clinical Investigation (ICTR), and Comparative Biomedical Sciences (CBMS) Graduate Programs. For more information, please click on the link for each program above.
Research Opportunities – Postdoctoral Fellows
Interested applicants with experience in cellular immunology, tumor models and/or molecular genetics may send a cover letter, CV, and emails for 3 references to firstname.lastname@example.org for consideration.
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Congratulations to Principal Investigator Christian Capitini, MD, along with Co-PI Jenny Gumperz, PhD, Department of Medical Microbiology & Immunology, and Fellow Nicholas Hess, PhD, on the funding of their pilot grant entitled, “Uncovering Predictive Cellular …September 1, 2020
Congratulations to Monica Cho, Graduate Research Assistant in the lab of Christian Capitini, MD, who was recently selected as a Trainee on the National Institutes of Health-funded T32 Cancer Biology Training Grant, directed by Bill …July 2, 2020
Al Dhaheri N, Wu N, Zhao S, Wu Z, Blank RD, Zhang J, Raggio C, Halanski M, Shen J, Noonan K, Qiu G, Nemeth B, Sund S, Dunwoodie SL, Chapman G, Glurich I, Steiner RD, Wohler …June 24, 2020
Nicholas Mohrdieck, rising senior at the UW, recently received a summer fellow award from the St. Baldrick’s Foundation for work in the laboratory of Christian Capitini, MD. As the result of a recent employee giving …June 12, 2020
Congratulations to UW undergraduate student David Turicek, who was awarded a Welton Summer Sophomore Honors Apprenticeship for the project, “Treating post-transplant B-cell acute lymphoblastic leukemia with blinatumomab as a radiation sparing immunotherapy.” This project will …June 1, 2020
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