Congratulations to Nader Shaikh, MD (University of Pittsburgh) and Ellen Wald, MD, Principal Investigators of a U01 grant from the National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH-NIAID). Their grant, entitled, “Efficacy of Antibiotics in Children with Sinusitis: Which Children Benefit?” is a 5-year award, in the amount of over $4.9 million in total costs. The objectives of this multi-site study are to determine which children diagnosed with acute sinusitis will benefit from antimicrobial therapy and if there are subgroups in which antibiotic therapy can be appropriately withheld based on symptoms. These objectives will be achieved by conducting a large, randomized, double-blind, placebo-controlled clinical trial in children 2 to 12 years of age with persistent or worsening presentations of acute sinusitis. Eliminating use of antibiotics in children for whom it is unnecessary and targeting only those children likely to benefit will constitute an important asset to both individual and public health.