Bruce Klein, MD

Position title: Professor, Division Chief

Division of Infectious Diseases
For Academic Inquiries: (608) 265-6050


BS, Boston University, Boston, Massachusetts
MD, Boston University School of Medicine, Boston, Massachusetts
Residency, Johns Hopkins Hospital, Baltimore, Maryland
Epidemic Intelligence Service, Centers for Disease Control and Prevention (CDC)
Fellowship, Infectious Diseases, University of Wisconsin­, Madison, Wisconsin

Professional Activities

Dr. Bruce Klein, tenured professor and chief, Division of Infectious Diseases, has an abiding commitment to service. He has served as the division leader of infectious diseases for over two decades. He held leadership roles in pediatrics as vice chair for research for several years. Klein is committed to faculty career development and has served on tenure and promotion committees, chairing both the university’s divisional committee on biological sciences and the medical school’s committee on promotion to professor. Other notable campus service activities have included membership on the University Athletic Board at the University of Wisconsin–Madison. At the national level, he served his research community in leadership roles including at the American Society for Microbiology, Medical Mycology, Gordon Research Conference on Immunology of Fungal Infections, and finally, as charter member on multiple NIH study section, including service as chair.

Klein has an affiliate appointment in the Department of Medicine and a joint appointment in the Department of Medical Microbiology and Immunology.

Clinical Interests

Klein is interested in common and rare serious infections that occur in children. Such infections are due to bacteria, viruses, fungi, and parasites. He is especially interested in systematic, life-threatening infections cause by fungi, which often occur in children with impaired immune defenses.

Research Interests

The projects in the Klein Research Group address common questions in pathogenesis and immunology: What are the mechanisms of fungal virulence? How does the host-fungal pathogen interaction define the progression of infection and disease? How does the innate and adaptive immune system respond to fungi, and what are the key immunological steps required for vaccine immunity to fungal pathogens? How does the immune response to fungi go awry, resulting allergic inflammation in response to inhaled mold?