The major focus of the Eldridge Research Group involves integrative cardiopulmonary physiology and pathophysiology. Of particular interest are cardiopulmonary interactions in congenital and acquired lung disease (congenital diaphragmatic hernia, bronchopulmonary dysplasia, asthma, hepatopulmonary syndrome and, bronchiolitis obliterans). My laboratory uses isolated heart-lung preparations, non-anaesthetized and anaesthetized animal models and humans in our investigations. The laboratory has specific expertise in the use of invasive methods including right heart and pulmonary artery catheterization, state-of-the-art non-invasive echocardiographic methods, exercise and hypoxia to investigate cardiopulmonary pathophysiology in small and large animal lung disease models and human subjects and patients. Currently, our specific research activities emphasize the following:
Right Heart-pulmonary Vascular Interactions in Bronchopulmonary Dysplasia (BPD)
We are investigating the long-term impact of premature birth and aggressive ventilator therapies including hyperoxia on cardiopulmonary function. We are measuring right heart function and pulmonary vascular reactivity during exercise and hypoxic stress in children and young adults with a history of premature birth and BPD. We are also investigating RV function and remodeling, RV metabolism and RV-pulmonary vascular coupling in a rat model of BPD. A new area of particularly interest in the potential role of mitochondrial dysfunction in RV response to pressure and volume loading in the developing heart. NIH-NHLBI R01 HL115061 (Eldridge).
Functional Characterization of Inducible Intrapulmonary Arteriovenous Pathways in Health Humans and Chronic Lung Disease
We are investigating the effects of pulmonary vascular pressures and flows, oxygen tension, and vasoactive mediators on the recruitment of inducible intrapulmonary arteriovenous pathways. We are also interested in the role of inducible intrapulmonary arteriovenous pathways in disease states such as cryptogenic stroke, BPD, and high altitude pulmonary edema. NIH-NHLBI R01 HL086897 (Eldridge)
Stem Cell Therapy and Lung Disease
We are interested in the value of mesenchymal stromal cells (MSC) to modulate the development of bronchiolitis obliterans following lung transplant in both rodent and pig models. We are also interested in the hemodynamic consequences and trafficking of MSC’s infused into the pulmonary circulation. We are also investigating the therapeutic value of MSC exizomes in our rat BPD model. NIH NHLBI HHSN268201000010C (Hei)
Diving Physiology and Medicine
Another major area of interest is the development of protective decompression strategies following saturation dives using a sheep model. We are also investigating the mechanisms of injury for both acute and chronic decompression injury using MRI (diffusion tensor imaging), and nuclear medicine scanning respectively. DOD Navy MSN154443 (Eldridge)
Marlowe Eldridge, MD, was recently awarded a 2-year grant of nearly $775,000 from the Naval Sea Systems Command (NAVSEA) for his project, “Determining DISSUB survival rates of 90 kg sheep rescued using SRDRS standard operating …December 26, 2019
Two UW-Madison undergraduate students in the lab of Marlowe Eldridge, MD, were recognized during the American Physiological Society’s Experimental Biology meeting in San Diego. Caitlin Jarrard and Rachel Harradine were 2018 Barbara A. Horwitz and …May 1, 2018
Congratulations to the following four Pediatric faculty members and their laboratories who were each recently awarded one-year Fall Competition grants from the UW Office of the Vice Chancellor for Research and Graduate Education: Marlowe Eldridge, …February 1, 2018
Every semester for 12 years, Marlowe Eldridge, MD, professor and chief of the Division of Pediatric Critical Care, has welcomed four to five undergraduate student researchers into his integrative cardiopulmonary physiology and pathophysiology lab. Students …December 1, 2017
Congratulations to Kristin Haraldsdottir, graduate student in the lab of Marlowe Eldridge, MD, who was selected to receive a Caroline tum Suden/Frances Hellebrandt Professional Opportunity Award, named in honor of Caroline tum Suden and Frances …March 1, 2017
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