Janet Legare, MD, clinical professor, Genetics and Metabolism, was named site Principal Investigator for the study, “A multi-center cohort study of achondroplasia.” The study, part of the Achondroplasia Natural History Study, was awarded $232,951 over three years from Johns Hopkins University and BioMarin Pharmaceutical, Inc. The first phase of this project was a retrospective natural history study involving patients with achondroplasia evaluated at the four academic institutions. The study had four study domains: anthropometry, surgical burden, sleep disordered breathing, and establishment of a radiographic catalogue. In this Phase 2 of the study, efforts to understand the natural history of achondroplasia will continue. The specific aims pertain to craniofacial structure; metabolism, growth and body composition; and pain/physical function related to lower extremity osteotomies and spinal surgery for subjects with achondroplasia.