Representative Publications

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Ralphe, J.C., Segar, J.L., Schutte, B.C., Scholz, T.D.  2004  Localization and function of the excitatory amino acid transporter type 1 in cardiac mitochondria. J Mol Cell Cardiol  37(1):33-41.

Ralphe, J.C., Bedell, K., Segar, J.L., Scholz, T.D. 2005 Correlation between myocardial malate/aspartate  shuttle activity and EAAT1 protein expression in hyper- and hypothyroidism. Am J Physiol Heart Circ Physiol; 288(5):H2521-6.

Ralphe, J.C., Nau, P.N., Mascio, C.E., Segar, J.L., Scholz, T.D.  2005  Regulation of Myocardial Glucose Transporters GLUT1 and GLUT4 in Chronically Anemic Fetal Lambs. Ped Res 2005;58(4):713-718.

Mamoi, N., Tinney, J.P., Liu, L.J., Elshershari, H., Hoffman, P.J., Ralphe, J.C., Keller, B.B., Tobita, K.  2008. Modest Maternal Caffeine Exposure Affects Developing Embryonic Cardiovascular Function. Am J Physiol Heart Circ Physiol2008 May;294(5):H2248-56.

Clause, K.C., Tinney, J.P., Li, J.L., Gharaibeh, B., Huard, J., Kirk, J.A., Schroff, S.G., Fujimoto, K.L., Wagner, W.R., Ralphe, J.C., Keller, B.B., Tobita, K. 2009. Cardiomyocyte induction from skeletal muscle derived stem cell using three-dimensional cell aggregate and gel bioreactor. Tissue Eng Part C Methods. 2010 Jun;16(3):375-85

De Lange, W., Hegge, L.F., Grimes, A., Brost, T., Tong, C.T., Moss, R.L., Ralphe, J.C. Neonatal Mouse-Derived Engineered Cardiac Tissue: A Novel Model System for Studying Genetic Heart Disease. Circ Res 2011;109:8-19.

Ralphe, J.C., De Lange, W.J. 3D Engineered Cardiac Tissue Models of Human Heart Disease: Learning More from our Mice. Trends in Cardiovasc Med 2013 Feb;23(2):27-32. PMID 23295081.

De Lange, W.J., Grimes, A., Hegge, L.F., Ralphe, J.C. Ablation of cardiac myosin binding protein C accelerates contractile kinetics in the absence of hypertrophic remodeling in engineered cardiac tissue. J. Gen Physiol 2013 Jan;141(1):73-84. PMID 23277475.

De Lange, W.J., Grimes, A., Hegge, L.F., Spring, A.M.,  Brost, T.M., Ralphe, J.C. The E258K HCM-causing mutation in myosin binding protein-C reduces contractile force and accelerates contractile kinetics by disrupting the cMyBP-C and myosin S2 interaction. J. Gen. Physiol. 2013Sept;142(3):241-255.

Raval, K. K., Tao, R., White, B.E., DeLange, W.J., Koonce, C.H., Yu, J., Kishnani, P.S., Thompson, J.A., Mosher, D.A., Ralphe, J.C., Kamp, T.J.  Pompe Disease Results in a Golgi-based Glycosylation Deficit in Human Induced Pluripotent Stem Cell- derived Cardiomyocytes. J Biol Chem, 2014 Dec 8,  PMID 25488666.

Moss, R.L., Fitzsimmons, D., Ralphe, J.C. MyBP-C regulates the rate and force of contraction in mammalian myocardium. Circ Res 2015, Jan 2;116(1):183-92. PMID 25552695.