Representative Publications

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Nanjappa, S.G., Heninger, E., Wüethrich, M., Sullivan, T. & Klein B.S. Protective anti fungal memory CD8+ T cells are maintained in the absence of CD4+ T cell help and cognate antigen in mice. J. Clin. Invest. 122(3), 987-99 (2012).

Rocco, N.M., Carmen, J.C. & Klein B.S. Blastomyces dermatitidis yeast cells inhibit nitric oxide production by alveolar macrophage inducible nitric oxide synthase. Infect Immun. 79(6):2385-95 (2011).

Wüethrich, M., Gern, B., Hung, C.Y., Ersland, K., Rocco N., Pick-Jacobs J., Galles, K., Filutowicz, H., Warner, T., Evans, M., Cole, G. & Klein, B.S. Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice. J. Clin. Invest. 121(2), 554-68 (2011).

Ersland K.K, Wüethrich, M., Klein, B.S. Dynamic interplay among monocyte–derived, dermal, and resident lymph node dendritic cells during the generation of vaccine immunity to fungi. Cell Host & Microbe, 7(6):474-87 (2010).

Gauthier, G.M., Sullivan, T.D., Gallardo, S.S., Brandhorst, T.T., Vanden Wymelenberg, A.J., Cuomo, C.A., Suen, G., Currie, C.R. & Klein, B.S. SREB, a GATA transcription factor that directs disparate fates in Blastomyces dermatitidis including morphogenesis and siderophore biosynthesis. PLoS Pathog. 6(4), e1000846 (2010).

Krajaejun, T., Gauthier, G.M., Rappleye, C.A., Sullivan, T.D. & Klein, B.S. Development and application of a green fluorescent protein sentinel system for identification of RNA interference in Blastomyces dermatitidis illuminates the role of septin in morphogenesis and sporulation. Eukaryot Cell 6, 1299-1309 (2007).

Nemecek, J.C., Wüethrich, M. & Klein, B.S. Global control of dimorphism and virulence in fungi. Science 312, 583-588 (2006).

Brandhorst, T.T., Gauthier, G.M., Stein, R.A. & Klein, B.S. Calcium binding by the essential virulence factor BAD-1 of Blastomyces dermatitidis. J. Biol. Chem. 280, 42156-42163 (2005).

Wüethrich, M., Filutowicz, H.I. & Klein, B.S. Mutation of the WI-1 gene yields an attenuated Blastomyces dermatitidis strain that induces host resistance. J. Clin. Invest. 106, 1381-1389 (2000).