Representative Publications

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Cole GT, Hung C, Sanderson S, Hurtgen B, Wüthrich M, Klein BS, Deepe G, Ostroff GR, Levitz SM. Novel Strategies to Enhance Vaccine Immunity Against San Joaquin Valley Fever. PLoS Pathogens. 2016

Wang H, LeBert V, Hung C, Cole G, Galles K, Klein BS, Wüthrich M. C-type lectin receptors differentially induce T17 cells and vaccine immunity to the endemic mycosis of North America. The Journal of Immunology. 2016                           

Klein BS, Wuethrich M, Gern B, Pick-Jacobs J, Cooney N. Vaccine induced protection against 3 systemic mycoses endemic to North America requires T17 cells. J Clin Invest. 2016

Klein BS, Wuethrich M, Gern B, Pick-Jacobs John, Cooney N. A requisite role for T17 cells in vaccine immunity to fungi that is independent of T1 immunity, but dependent on Myd88. J Clin Invest. 2016

Xu X, Pocock GM, Sharma A, Peery SL, Fites JS, Felley L, Zarnowski R, Stewart D,  Berthier E, Klein BS, Sherer NM, Gumperz JE. Human iNKT Cells Promote Protective  Inflammation by Inducing Oscillating Purinergic Signaling in Monocyte-Derived DCs. Cell reports. 2016; 16(12):3273-85. PubMed PMID: 27653689, PMCID: PMC5043518

Wang H, Li M, Hung CY, Sinha M, Lee LM, Wiesner DL, LeBert V, Lerksuthirat T, Galles K, Suresh M, DeFranco AL, Lowell CA, Klein BS, Wüthrich M. MyD88 Shapes Vaccine Immunity by Extrinsically Regulating Survival of CD4+ T Cells during the  Contraction Phase. PLoS pathogens. 2016; 12(8):e1005787. PubMed PMID: 27542117, PMCID: PMC4991787

Xiong Y, Lingrel JB, Wüthrich M, Klein BS, Vasudevan NT, Jain MK, George M, Deepe GS Jr. Transcription Factor KLF2 in Dendritic Cells Downregulates Th2 Programming via the HIF-1α/Jagged2/Notch Axis. mBio. 2016; 7(3). PubMed PMID: 27302755, PMCID: PMC4916374

Wang H, LeBert V, Li M, Lerksuthirat T, Galles K, Klein B, Wüthrich M. Mannose Receptor Is Required for Optimal Induction of Vaccine-Induced T-Helper Type 17 Cells and Resistance to Blastomyces dermatitidis Infection. The Journal of infectious diseases. 2016; 213(11):1762-6. PubMed PMID: 26931447, PMCID: PMC4857467

Garfoot AL, Shen Q, Wüthrich M, Klein BS, Rappleye CA. The Eng1 β-Glucanase Enhances Histoplasma Virulence by Reducing β-Glucan Exposure. mBio. 2016; 7(2):e01388-15. PubMed PMID: 27094334, PMCID: PMC4850272

Sterkel AK, Lorenzini JL, Fites JS, Subramanian Vignesh K, Sullivan TD, Wuthrich  M, Brandhorst T, Hernandez-Santos N, Deepe GS Jr, Klein BS. Fungal Mimicry of a Mammalian Aminopeptidase Disables Innate Immunity and Promotes Pathogenicity. Cell host & microbe. 2016; 19(3):361-74. PubMed PMID: 26922990, PMCID: PMC5088612

Wüthrich M, Gern B, Hung CY, Ersland K, Rocco N, Pick-Jacobs J, Galles K, Filutowicz H, Warner T, Evans M, Cole G, Klein B. Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice.  The Journal of clinical investigation. 2016; 126(2):795. PubMed PMID: 26829626, PMCID: PMC4731166