Laura Tetri, PhD, Awarded ICTR-MSTP Pilot Award
Congratulations to Laura Tetri, PhD, and mentors Jennifer Rehm, MD and Aaron Carrel, MD, for their recent UW Institute for Clinical and Translational Research-Medical Scientist Training Program (ICTR-MSTP) Pilot Award. This $10,000, one-year grant, for the project entitled, "Linking sex and fitness with metabolic disease in obese children," is a focused initial investigation into the relationship between cardiovascular fitness (CVF), puberty, and sex. CVF is not a well understood nor utilized clinical measure, much less, the relationship between CVF and metabolic disease. Understanding the role of CVF in indices of metabolic disease may provide a modifiable variable in these children's lives that could reduce the negative effects of obesity.
Christian Capitini, MD, Awarded Research Scholar Grant from American Cancer Society
Christian Capitini, MD, along with Co-Investigators Paul Sondel, MD, PhD, and Sean Fain, PhD (Medical Physics), were recently awarded a four-year, Research Scholar Grant from the American Cancer Society (ACS), for the project entitled, "Ex vivo activated NK cells and immunocytokine for pediatric cancers." This grant, for $792,000 (total costs), will provide preclinical evidence for a potential platform for incorporating recently developed immunotherapies, namely immunocytokine and natural killer (NK) cells, for treatment of neuroblastoma and osteosarcoma.
Vivek Balasubramaniam, MD, Awarded a 2017 Hartwell Individual Biomedical Research Award
Congratulations to Vivek Balasubramaniam, MD, who received one of twelve grants awarded nationally by The Hartwell Foundation in their 2017 Hartwell Individual Biomedical Research Award competition. Along with three years and $300,000 of support, Dr. Balasubramaniam receives recognition as a Hartwell Investigator. His grant, entitled "Application of Cellular-Derived Therapies for the Regeneration of Lung Structure and Function," will determine the specific components and mechanisms of innovative use of extracellular vesicles (EVs) in the treatment of bronchopulmonary dysplasia (BPD) in an animal model, using novel imaging and tracking techniques to understand therapeutic targets of these EVs. The hope for premature infants that suffer from BPD is that investigators gain a better understanding of how EVs work and can develop new innovative therapies to cure lung diseases of prematurity. The link to the full story on The Hartwell Foundation's web site can be found here: http://thehartwellfoundation.com/2017/2017_Investigators.shtml or at www.thehartwellfoundation.org
First-Year Resident Allison Heizelman, MD, Inducted into AOA Honor Medical Society
First-year resident Allison Heizelman, MD, was inducted into the prestigious Alpha Omega Alpha (AOA) Honor Medical Society during an April 6, 2018, ceremony at the Carson Gulley Center on the UW-Madison campus.
“She impressed me with her consistent excellence and her grace under fire: not only was she always prepared with thorough, thoughtful plans for each of her patients on a very active service; but she also demonstrated the most effective parent communication during rounds,” noted her nominator.
Election to AOA is a lifelong honor signifying a lasting commitment to scholarship, leadership, professionalism, and service.
Department Chair Ellen Wald, MD, a long-time member of the AOA, delivered the keynote address at the evening’s ceremony and banquet.
Dr. Nicole St. Clair Re-elected to Executive Committee of the AAP Section on International Child Health
Congratulations to Nicole St Clair, MD (Associate Professor (CHS), Division of Pediatric Hospital Medicine), who was elected for a second term on the executive committee of the Section on International Child Health of the American Academy of Pediatrics. Her next term will begin on November 1, 2018, and continue through the AAP's 2021 National Conference and Exhibition.
Pediatric Investigators Receive Two Grants from Children's Hospital of Wisconsin
Congratulations to Mala Mathur, MD, MPH, PI and Co-Investigators Cristina Delgadillo, MD, Jessica Babal, MD, Tim Chybowski, MD, and Megan Neuman, MD, for their $20,000 grant entitled, "Wisconsin State Medical Home Initiative: Shared Plans of Care Grant for ADHD." In this one-year grant, from the Children's Hospital of Wisconsin on behalf of Children's Health Alliance of Wisconsin's Medical Home Initiative, the team aims to better understand the needs of families in managing a child with ADHD through the partnering of a youth and family member on the team and through focus groups; to identify through the pre and post surveys of families, what activities of the health care team are most valuable to families in the long term management of their child with ADHD; and to increase the number of families who understand the medical home through "Every Child Deserves a Medical Home" brochure that they we will create.
Mary Ehlenbach, MD, PI, and Ryan Coller, MD, MPH,Co-PI also received a one-year grant, from the Children's Hospital of Wisconsin on behalf of Children's Health Alliance of Wisconsin's Medical Home Initiative. Their $20,000 award is entitled, "Advancing family-centered care coordination for children and youth with special health care needs," and will engage the Pediatric Complex Care Program to engage stakeholders and families to improve the shared care planning experience and documentation. Congratulations!
David McCulley, MD, Part of Consortium Awarded NIH P01 Grant
Researchers from Massachusetts General Hospital (including Overall PI, Dr. Patricia Donahoe), Boston Children's Hospital, Columbia University, the Jackson Laboratory, University of California, San Diego, and the UW Department of Pediatrics, including Co-Investigator David McCulley, MD, were awarded a Program Project Grant from the National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NIH-NICHD) entitled, "Gene Mutation and Rescue in Human Diaphragmatic Hernia." Dr. McCulley's role will include creating and analyzing new conditional mouse alleles using CRISPR/Cas9 technology as part of Project 3, which will focus on evaluation of lung and pulmonary vascular phenotypes that result from deletion of genes implicated by genetic and genomic analyses of patients with congenital diaphragmatic hernia (CDH). The UW subaward, in the amount of ~$70,000 in direct costs per year of this 5-year grant, will utilize the UW Genome Editing and Animal Models Core (GEAM) for this work.
Yashoda Naik, MD, Awarded 2018 NASPAG Fellows Research Grant
Congratulations to Endocrinology & Diabetes Postdoctoral Fellow Yashoda (Mita) Naik, MD, who was recently awarded a $1,000 Fellows Research Grant from the North American Society for Pediatric and Adolescent Gynecology (NASPAG). Her one-year pilot grant entitled, "Effect of sex hormones on ectopic fat deposition in overweight/obese pubertal children," under the mentorship of Jennifer Rehm, MD, will inform the longitudinal study of the effects of sex hormones on differential adipose tissue distribution in children undergoing hormonal manipulation.
Medical Student Claire Baniel Awarded Howard Hughes Medical Research Fellows Award
Congratulations to UW medical student Claire Baniel on receiving a 2018-2019 Medical Fellows Research Award from the Howard Hughes Medical Institute (HHMI). This one-year award in the amount of $43,000 is for her project entitled, "Endogenous antibody response: role in the potentiation and outcome of combination anti-melanoma in situ immunotherapies." Under the mentorship of Paul Sondel, MD, PhD, her project will characterize antigens recognized by endogenous antibodies as well as explore the utilization of endogenous antibodies as therapeutic enhancers, through use of immunologic assays including ELISA, flow cytometry, cell mediated cytotoxicity assays, high density peptide array, and mouse work.
Summer Student Fellowship Awarded to Capitini Laboratory
Congratulations to Katharine Tippins, medical student, and her mentor, Christian Capitini, MD, for receiving a Summer Student Fellowship from St. Baldrick's Foundation in the amount of $5,000. This 4-month Summer Fellowship is for her project entitled, "Generating an NK-mediated graft-versus-tumor effect against osteosarcoma," which she will use murine bone marrow transplant (BMT) models to develop evidence for a clinically applicable combined strategy that utilizes immunocytokines (IC) to enhance anti-tumor properties of immunologically activated, ex vivo activated natural killer (NK) cells. The underlying goal of this study is to develop a bone marrow transplant that can cure osteosarcoma.