J. Scott Fites, PhD awarded Postdoctoral Fellowship from American Heart Association

Bruce Klein, MD
Bruce Klein, MD

J. Scott Fites, PhD, Postdoctoral Fellow in the laboratory of Bruce Klein, MD, was recently awarded a Midwest Affiliate Summer 2016 Postdoctoral Fellowship from the American Heart Association (AHA). This 2-year grant, in the amount of $102,550, is for his project entitled, "Harnessing a long-lived neutrophil to fight systemic fungal infections." This neutrophil population - referred to as a neutrophil-dendritic cell (PMN-DC) - has features of both neutrophils and DCs. This project will investigate the emergence and activities of PMN-DCs during Aspergillus and Candida infections in murine models; delineate the professional phagocyte and antigen-presenting functions of PMN-DCs important in antifungal immunity; and elucidate the inflammatory signals that drive PMN-DC development in vivo, which is a critical gap in knowledge with therapeutic implications. The long-term impact of this research will be in developing PMN-DC targeted immunotherapies to treat lethal Aspergillus and Candida infections. Congratulations, Scott!