Division Highlights - Infectious Diseases

The Division of Infectious Diseases cares for children with common, complex or potentially life-threatening infectious diseases and illnesses.

Research interests include international health, immunization efficacy, vaccine preventable disease epidemiology and policy, respiratory tract infections, urinary tract infections, arbovirus infections and fungal infections.

2017 Highlights

  • James Conway, MD, FAAP, received a Citation of Commendation from the State of Wisconsin, with bipartisan support, co-sponsored by Senators Stephen Nass and Fred Risser and Representatives Melissa Sargent and Terese Berceau, in recognition of being named Delta Chi Fraternity 2017 Man of the Year, and for his “inspiring work in the medical field.” He was honored with a ceremony at the Wisconsin State Legislature in October 2017.

  • Bruce Klein, MD, received a 2-year, $408,030 R21 grant from the National Institutes of Health/ National Institute of Allergy and Infectious Diseases (NIH/NIAID) for his project, "Hybrid Histidine Kinase: A Drug Target and Path to Anti-Fungal Drug Development," which aims to discover the mode of action of anti-fungal drugs that require group III hybrid histidine kinases (HHKs).

    In addition, James Gern, MD, and Bruce Klein, MD, are part of a team of investigators led by PI Cameron Currie, PhD, on a new, two-year UW2020 grant, “The Human Microbiome in Health and Disease”. The award leverages the Children’s Respiratory Research and Environment Workgroup (CREW), led by Dr. Gern, and the Wisconsin Longitudinal Study (WLS), one of the longest-running investigations of human health.

    Finally, two learners in Dr. Klein’s laboratory received research fellowships. Postdoctoral fellow J. Scott Fites, PhD, received a two-year, $102,550 Midwest Affiliate Postdoctoral Fellowship from the American Heart Association for his project, "Harnessing a Long-Lived Neutrophil to Fight Systemic Fungal Infections,” Graduate student Richard Merkhofer, received a four-year, $161,276 Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship for MD/PhD and Other Dual Degrees from the National Institutes of Health, National Institute on Minority Health and Health Disparities for his project, "Pathogenesis of Fungal Infectious Disease in the Hmong Population.”

  • Fellow Emma Mohr, MD, PhD, received the 2017-2019 Pediatric Infectious Diseases Society’s Stanley and Susan Plotkin and Sanofi Pasteur Fellowship Award for her project, "Development of a Macaque Congenital Zika Syndrome Model: Fetal Zika Virus Tissue Distribution and Pathology." Dr. Mohr was also a co-author on PLoS Pathogens articles on maternal-fetal Zika virus transmission in pregnant rhesus macaques and the mechanisms of Pegivirus in a macaque model of HIV infection.

    Fellow Joseph McBride, MD, was a co-author with Dr. Klein on a Clinical Chest Medicine article reviewing the clinical manifestations and treatment of blastomycosis.

  • Marcel Wüethrich, PhD, together with Dr. Klein as co-investigator, received a four-year, $2.2 million grant renewal from the National Institutes of Health–National Institute of Allergy and Infectious Diseases for their project, "Regulation of Vaccine-Induced Anti-Fungal Th17 Cells." The renewal supports years 6-9 of this project, which will investigate a novel adjuvant that elicits cellular immune responses needed for better vaccines.

    Dr. Wüethrich also received a one-year $50,000 UW-Madison Technology Innovation Fund grant for his project, "BI-Eng3—An Adjuvant for Vaccine Prevention of Global Pathogens."

 

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