Division Highlights - Hematology, Oncology & Bone Marrow Transplant

The Division of Hematology, Oncology and Bone Marrow Transplant provides state-of-the-art integrated therapies, including stem cell transplant, aimed at curing malignancies and treating hematological disorders in children.

Research interests include ways to recognize and destroy cancer cells using immunologic, cellular and molecular biologic pathways, bone marrow transplantation as immunotherapy, cancer survivorship, neuro-oncology and palliative care.

2016 Highlights

  • Christian Capitini, MD, received a two-year, $250,000, Hyundai Hope on Wheels Scholar Award for his project, “Anti-GD2 Immunocytokine and NK Cell Infusions for Neuroblastoma.” He also received a one-year, $66,523 grant from the UW Office of the Vice Chancellor for Research and Graduate Education for his project, "Enhancing the Graft-Versus-Tumor Effect Against Neuroblastoma."

    In addition, Dr. Capitini, along with principal investigator Krishanu Saha, PhD, and co-principal investigator David Beebe, PhD, received a two-year, $300,000 grant from the National Science Foundation for the project, "EAGER BIOMANUFACTURING: A Microscale Testbed to Assay and Manufacture CAR T-Cell Immunotherapies."

    Finally, Dr. Capitini received a $5,000 Summer Fellowship from the St. Baldricks's Foundation to fund the work of Nicole Piscopo, a student collaborating with his lab on the project, “Tagging CAR T Cells for GD2+ Cancers.”
  • Kenneth DeSantes MD, received the endowed Crawford Professorship of Pediatric Oncology, and also became chief of the Division of Pediatric Hematology, Oncology and Bone Marrow Transplant.

    In addition, Dr. DeSantes is the chairman and PI of the first clinical collaborative trial to be open at all eight sites of the North American Pediatric Cancer Dream Team (supported by the Stand Up to Cancer Foundation, the St. Baldrick’s Foundation and the American Association of Cancer Research). This novel clinical immunotherapy trial is titled, “A Phase 1, Open-Label, Dose Escalation Study of MGA271 in Pediatric Patients with B7-H3-Expressing Relapsed or Refractory Solid Tumors.”
  • Inga Hofmann, MD, accepted an invitation to serve as vice chair of the American Society of Hematology’s Scientific Committee on Hematopathology and Clinical Laboratory Hematology in 2017. She will also chair the same committee in 2018.

    In addition, Dr. Hofmann assisted in American Family Children’s Hospital being designated a Center of Excellence for MDS (pediatric) by the MDS International Foundation.
  • Mario Otto, MD, PhD, received a three-year, $75,000 grant from Cannonball Kids' Cancer Foundation for his clinical trial, “TCR-α/β+ and CD19+ Depleted KIR/KIR Ligand-Mismatched Haploidentical Hematopoietic Stem Cell Transplant and Zoledronate for Pediatric Relapsed/Refractory Hematologic Malignancies and High Risk Solid Tumors." Dr. Otto also received a one-year, $50,000 pilot award from the UW Carbone Cancer Center (UWCCC) for his project.

    In addition, Dr. Otto was one of 48 American Association of Immunologists (AAI) members to receive a 2016 AAI Careers in Immunology Fellowship. The fellowship will provide one year of salary support for Kyle Kloepping, PhD, a student in his lab, for the project, "A Novel Phospholipid Ether Analog to Combine Targeted Molecular Radiotherapy and Immunotherapy in Pediatric Solid Tumors."
  • Diane Puccetti, MD, was invited to join the Scientific Advisory Board for Quality of Life for the Brain Tumour Charity in the United Kingdom.
  • Paul Sondel, MD, PhD, received the Society for Immunotherapy of Cancer’s (SITC) top award, the Richard V. Smalley, MD Memorial Lectureship Award, for his decades of work in developing immunotherapies for childhood cancers.

    In addition, Dr. Sondel, along with co-principal investigators Mario Otto, MD, PhD, Jamey Weichert, PhD, Zachary Morris, MD, PhD, and Bryan Bednarz, PhD, received a two-year, $382,015 UW2020 WARF Discovery Initiative grant for the project, “Combining Radiotherapeutic with Antitumor Antibody and IL2 to Create a Potent In Situ Cancer Vaccine.”

    Finally, two students in Dr. Sondel’s lab received research awards: Kayla Rasmussen received a $5,000 John Emory Morris UWCCC Undergraduate Summer Research Award, and Monica Gressett received a $2,500 UW School of Letter and Sciences Ann Haney Senior Honors Research Scholarship.
  • In 2016, U.S. News and World Report ranked American Family Children’s Hospital (AFCH) among the top 50 children’s hospitals for pediatric oncology.

 

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