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Representative Publications

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Anna Huttenlocher, Miriam Shelef and JA Smith, Neutrophils in Pediatric Rheumatology, Current Opinions in Rheumatology, Sep 27(5):500-4, 2015.

Michael M. Ward, Atul Deodhar, Elie A. Akl, Andre Lui, Joerg Ermann, Lianne S. Gensler, JA Smith, David Borenstein, Jayme Hiratzka, Pamela F. Weiss, Robert D. Inman, Vikas Majithia, Nigil Haroon, Walter P. Maksymowych, Janet Joyce, Bruce Clark, Robert A. Colbert, Mark Figgie, David Hallegua, Pamela Prete, James T. Rosenbaum, Judith Stebulis, Filip van den Bosch, David T.Y. Yu, Amy S. Miller, John D. Reveille, Liron Caplan, American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network 2014 Recommendations for the Treatment of Ankylosing Spondylitis and Non-radiaographic Axial Spondyloarthritis, in press Arthritis and Rheumatology, 2015.

Marina Durward-Diioia, Jerome Harms, Mike Khan, JA Smith, Gary A Splitter, CD8+ T cell exhaustion, suppressed IFN-g production and delayed memory response induced by chronic Brucella melitensis infection, in revision Infection and Immunity, 2015.

Aseem Pandey, Qing-Ming Qin, Elizabeth Di Russo Case, James E Samuel, Judith A Smith, Thomas A Ficht, Paul de Figueiredo, Space: a final frontier for vacuolar pathogens, Frontiers in Cell and Developmental Biology journal, in revision, 2015.

JA Smith, Update on Ankylosing Spondylitis: current concepts in pathogenesis, (invited review), Current Asthma and Allergy Reports, Jan 15(1):489, 2015. PMID 25447326.

JA Smith, A new paradigm: innate immune sensing of viruses via the Unfolded Protein Response, (invited review) for Frontiers in Immunology and Frontiers in Microbiology, May 16(5):222, 2014. PMID 24904537, PMCID 4032990.

JA Smith and RA Colbert, The IL-23/IL-17 Axis in Spondyloarthritis Pathogenesis: Th17 and Beyond, (invited review), Arthritis and Rheumatology, 66(2): 231-241, 2014. PMID 24504793, PMCID 4058712.

I. Fert, N Cagnard, S. Glatigny, F. Letourneur, S. Jaques, JA Smith, RA Colbert, JD Taurog, G Chiocchia, LM Araujo, M Breban, Reverse interferon signature is characteristic of antigen-presenting cells in human and rat spondyloarthritis.. Arthritis and Rheumatology, 66(4): 841-851, 2014. PMID 24757137, PMCID 4226235.

JA Smith, D Magnani, M Khan, J Harms, G Radhakrishnan, YP Liu, GA Splitter, Brucella induces an Unfolded Protein Response that enables intracellular replication in macrophages. Plos Pathogens, 9(12): e1003785, 2013. PMID 24339779, PMCID 3855547.

Gavala ML, Liu YP, Lenertz LY, Zeng L, Blanchette JB, Bertics PJ, Smith JA, Nucleotide Receptor P2RX7 Stimulation Enhances LPS-induced IFN-β production in Murine Macrophages. Journal of Leukocyte Biology 94(4): 759-768, 2013. PMID 23911869, PMCID 3774844.

Liu YP, Zeng L, Tian A, Bomkamp A, Rivera D, Gutman D, Barber GN, Smith JA, Endoplasmic reticulum stress regulates the innate immunity critical transcription factor interferon regulatory factor 3, Journal of Immunology, 189(9): 4630-9, 2012. PMID 23028052, PMCID 3478468.

Kuemmerle-Deschner JB, Hachulla E, Cartwright R, Hawkins PN, Tran TA, Bader-Neunier B, Hoyer J, Gattorno M, Gul A, Smith J, Leslie KS, Jimenez S, Patel N, Widmer A, Preiss R, Lachmann HJ, Two-year results from an open-label, multicenter, phase 3 study evaluating the safety and efficacy of canakinumab in patients with cryopyrin-associated periodic syndrome across different severity phenotypes, Ann Rheum Dis, 70(12): 2095-102, 2011. PMID 21859692.

Zeng, L., Lindstrom, M., Smith, J.A., Ankylosing spondylitis macrophage production of higher levels of interleukin-23 in response to lipopolysaccharide without induction of a significant unfolded protein response., Arthritis and Rheum 63(12): 3807-3817, 2011. PMID 22127699, PMCID 3228355.

Zeng, L., Liu, Y.P., Chen, H., Qi, L., Smith, J.A., XBP-1 couples endoplasmic reticulum stress to augmented IFN-β induction via a cis-acting enhancer in Macrophages, J Immunol 185(4):2324-30, 2010. PMID 20660350, PMCID 2916979.

Delay, M.L., Turner, M.J., Klenk, E., Smith, J.A., Sowders, D.P., Colbert, R.A., HLA-B27 Misfolding and the Unfolded Protein Response Augment IL-23 Production and are Associated with Th17 Activation in Transgenic Rats, Arthritis Rheum 60(9): 2633-2643, 2009. PMID 19714651, PMCID2893331

Smith, J.A., Testing for Rheumatologic Diagnoses in Children, Touchbriefings: US Pediatrics (5):28-32, 2010 and European Pediatrics (3):30-34, 2009. PMID 22059094, PMCID 3207318.

Smith, J.A., Barnes, M.D., Hong, D., Delay, M.D., Inman, R.D., Colbert, R.A., Gene expression analysis of macrophages derived from ankylosing spondylitis patients reveals interferon-gamma dysregulation, Arthritis Rheum 58(6): 1640-49, 2008. PMID 18512784, PMCID 2888278.

Smith, J.A., Turner, M.J., Hong, D., Delay, M.L., Colbert, R.A. Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1, Eur. J. Immunol 38(5): 1194-203, 2008. PMID 18412159, PMCID 2838478.

Smith, J.A., Marker-Hermann, E., Colbert, R.A., Pathogenesis of ankylosing spondylitis: Current concepts, Best Pract Res Clin Rheumatol 20(3): 571-91 2006. PMID 16777583

Cain, J.A., Smith, J.A., Ondr, J.K., Wang, B., Katz, J., NKT Cell and Interferon-γ Establish the Regulatory Environment for the Control of Diabetogenic T cells in the NOD Mouse, J Immunol 176: 1645-1654, 2006. PMID 16424194

Turner, M.J, Sowders, DP, Delay, ML, Mahaptra, R., Bai, S., Smith, J.A, Colbert, R.A, HLA-B27 misfolding in transgenic rats is associated with activation of the unfolded protein response, J Immunol 175(4): 2438-2448, 2005. PMID 1608185

Carrasco, R., Smith, J.A., Lovell, D.J., Biological therapy for juvenile rheumatoid arthritis: current status, Journal of Pediatric Drugs 6 (3) 137-146, 2004. Author erratum: 7(2): 136, 2005. PMID 15170361

Tang, Q., Smith, J.A., Szot, G.L., Zhou, P., Alegre, M.L., Henriksen, K.J., Thompson, C.B., and Bluestone, J.A., CD28/B7 Regulation of Anti-CD3-Mediated Immunosuppression In Vivo, Journal of Immunology, 170: 1510-1516, 2003. PMID 12538715

Smith, J.A., Bluestone, J.A., Partial signals delivered by FcR non-binding anti-CD3 mAbs differentially regulate individual T helper subsets. J. Immunol. 160(10): 4841-4849, 1998. PMID 9590231

Smith, J.A., Bluestone, J.A., T cell inactivation and cytokine deviation promoted by anti-CD3 mAbs. Current Opinions in Immunol. 9(5): 648, 1997. PMID 9368773

Smith, J.A., Tso, J.Y., Clark, M.R., Cole, M.S., Bluestone, J.A., Non-mitogenic anti-CD3 monoclonal antibodies deliver partial TCR signals and induce clonal anergy. J.Exp.Med.185(8): 1413-1422,1997. PMID 9126922, PMCID 2196281

Madrenas, J., Chau, L.A., Smith, J.A., Bluestone, J.A., Germain, R.N., The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands. J. Exp. Med. 185(2): 219-229, 1997. PMID 9016871, PMCID 2196122

Alegre, M., Sattar, H.A., Tso, J.Y., Smith, J.A., Cole, M., Bluestone,J.A., An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity. J.Immunol. 155(3): 1544-1555, 1995. PMID 7636216

Alegre,M., Sattar, H.A., Herold, K.C., Smith, J.A., Tepper,M.A., Bluestone, J.A., Prevention of the humoral response induced by anti-CD3 monoclonal antibodies by deoxyspergualin in a murine model. Transplantation 57: 1786-1794, 1994. PMID 8016885

Last updated: 06/26/2015
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