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Representative Publications

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Smith, J.A., Turner, M.J., Hong, D., Delay, M.L., Colbert, R.A. Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1, Eur. J. Immunol 38(5): 1194-203, 2008. PMID: 18412159.

Smith, J.A., Barnes, M.D., Hong, D., Delay, M.D., Inman, R.D., Colbert, R.A., Gene expression analysis of macrophages derived from ankylosing spondylitis patients reveals interferon-gamma dysregulation, Arthritis Rheum 58(6): 1640-49, 2008. PMID: 18512784.

Delay, M.L., Turner, M.J., Klenk, E., Smith, J.A., Sowders, D.P., Colbert, R.A., HLA-B27 Misfolding and the Unfolded Protein Response Augment IL-23 Production and are Associated with Th17 Activation in Transgenic Rats, Arthritis Rheum 60(9): 2633-2643, 2009. PMID: 19714651.

Smith, J.A., Testing for Rheumatologic Diagnoses in Children, (invited review, Touchbriefings: US Pediatrics (5):28-32, 2010 and European Pediatrics (3):30-34, 2009.

Zeng, L., Liu, Y.P., Chen, H., Qi, L., Smith, J.A., XBP-1 couples endoplasmic reticulum stress to augmented IFN-b induction via a cis-acting enhancer in Macrophages, J Immunol 185(4):2324-30, 2010. PMID: 20660350.

Zeng, L., Lindstrom, M., Smith, J.A., Ankylosing spondylitis macrophages produce greater interleukin-23 in response to lipopolysaccharide without significant Unfolded Protein Response induction, Arthritis and Rheum 63(12): 3807-3817, 2011. PMID: 22127699.

Kuemmerle-Deschner JB, Hachulla E, Cartwright R, Hawkins PN, Tran TA, Bader-Neunier B, Hoyer J, Gattorno M, Gul A, Smith J, Leslie KS, Jimenez S, Patel N, Widmer A, Preiss R, Lachmann HJ, Two-year results from an open-label, multicenter, phase 3 study evaluating the safety and efficacy of canakinumab in patients with cryopyrin-associated periodic syndrome across different severity phenotypes, Ann Rheum Dis, 70(12): 2095-102, 2011. PMID: 21859692.

Liu YP, Zeng L, Tian A, Bomkamp A, Rivera D, Gutman D, Barber GN, Smith JA, Endoplasmic reticulum stress regulates the innate immunity critical transcription factor interferon regulatory factor 3, J Immunol, 189(9): 4630-9, 2012. PMID: 23028052.

Gavala ML, Liu YP, Lenertz LY, Zeng L, Blanchette JB, Bertics PJ, Smith JA, Nucleotide Receptor P2RX7 Stimulation Enhances LPS-induced IFN-b production in Murine Macrophages. In revision for the Journal of Leukocyte Biology, 2013.

JA Smith, D Magnani, M Khan, J Harms, G Radhakrishnan, YP Liu, GA Splitter, Brucella induces an Unfolded Protein Response that enables intracellular replication in macrophages. In revision for Plos Pathogens, 2013.


Last updated: 03/12/2014
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