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Pediatrics Grand Rounds- David Hildeman, PhD

July 25 @ 7:30 am - 8:30 am

Date: Thursday, July 25, 2024

Time: 7:30-8:30 a.m. CST via Zoom

Zoom Link

Title: Single Cell Analysis Provides Insights into Human Allograft Rejection

Session Overview: 

Rejection remains the number one cause of allograft failure, largely because we lack understanding of basic mechanisms underlying allograft rejection.  We applied single cell genomics approaches to interrogate the transcriptomes of cells within the rejecting kidney and urine.  A few highlights of our work include: (i) gene expression of clonally expanded CD8+ T cells (CD8EXP) driving rejection depends upon the patient’s immunosuppression; (ii) transcriptomic analysis of CD8EXP suggests therapeutic targets for anti-rejection treatment; (iii) the urine contains clonally identical CD8EXP with similar gene expression compared to the biopsy.  This approach provides a platform that can be tailored to each patient where therapeutic targets can be rationally defined, mechanistically based, and exploited.

Speaker: David Hildeman, PhD, professor, UC Department of Pediatrics
Cincinnati Children’s Hospital




Please text the 6-letter code provided in the livestream lecture to 608-260-7097 for CME credit.

Series Overview: Pediatric Grand Rounds is a weekly multidisciplinary and interprofessional conference designed to improve a participant’s ability to practice pediatric medicine, including patient care, conducting healthcare research, providing medical education, addressing public health, and implementing innovation.

Target Audience: MD/DO, RN, APRN, Residents, Fellows, and other Trainees.

Global Learning Objectives:

  1. Identify state of the art, evidence-based practices for prevention, diagnosis and treatment in pediatric medicine
  2. Analyze issues of diversity, equity, inclusion, and justice relevant to pediatric care
  3. Collaborate and communicate effectively with other health care professionals, community members and families to advocate for the health care needs of children
  4. Describe new scientific advances and trends in pediatric medicine that may be translatable and impact future patient care
  5. Identify roles and responsibilities as part of a healthcare team that functions in value-driven, ethical environments

Accreditation Statement – Log into your ICEP account to view sessions, check your credits and more!

In support of improving patient care, the University of Wisconsin–Madison ICEP is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

Credit Designation Statements

American Medical Association (AMA)

The University of Wisconsin–Madison ICEP designates this live activity for a maximum of 1 AMA PRA Category 1 Credit™.  Physicians should claim only the credit commensurate with the extent of their participation in the activity.

American Nurses Credentialing Center (ANCC)

The University of Wisconsin–Madison ICEP designates this live activity for a maximum of 1 ANCC contact hour.

American Board of Pediatrics (ABP) (for select sessions only — see individual session details)

Successful completion of this CME activity, which includes participation in the activity and individual assessment of and feedback to the learner, enables the learner to earn up to 1 MOC points in the American Board of American Board of Pediatrics’ (ABP) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABP MOC credit.

Participant completion information will be shared with the ABP through PARS. By recording your attendance at this event, you are giving UW-ICEP permission to share this information with ABP.

Continuing Education Units

The University of Wisconsin–Madison ICEP, as a member of the University Professional & Continuing Education Association (UPCEA), authorizes this program for 0.1 continuing education units (CEUs) or 1 hour.


July 25
7:30 am - 8:30 am
Event Category:


Via Zoom