Representative Publications

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Cancer Immunotherapy and Stem Cell Graft Design

Otto M, Barfield RC, Iyengar R, Gatewood J, Muller I, Holladay MS, Houston J, Leung W, Handgretinger R.  Human gamma delta T cells from G-CSF-mobilized donors retain strong tumoricidal activity and produce immunomodulatory cytokines after clinical-scale isolation.  J Immunother 28:73-78, 2005. PMID: 15614047.

Otto M, Barfield RC, Martin WJ, Iyengar R, Leung W, Leimig T, Chaleff S, Gillies SD, Handgretinger R. Combination immunotherapy with clinical-scale enriched human γδ T cells, hu14.18 antibody and the immunocytokine Fc-IL7 in disseminated neuroblastoma. Clin Cancer Res 11:8486-8491, 2005. PMID: 16322312.

Otto M, Chen X, Martin WJ, Leung W, Knowles J, Holladay MS, Houston J, Handgretinger R, Barfield RC. Selection of stem cells by using antibodies that target different CD34 epitopes yields different patterns of T cell differentiation. Stem Cells 25(2):537-42, 2007. PMID: 17023516.

Chaleff S, Otto M, Barfield RC, Leimig T, Iyengar R, Martin WJ, Holladay M, Houston J, Geiger T, Huppert V, Handgretinger R. A large-scale method for the selective depletion of αβ T-lymphocytes from PBSC for allogeneic transplantation. Cytotherapy 9(8): 746-54, 2007. PMID: 17917892.

Nano-Oncology and Small Molecule Tumor Targeting

Baiu DC, Brazel CS, Bao Y, Otto M.: Interactions of Iron Oxide Nanoparticles with the Immune System: Challenges and Opportunities for their Use in Nano-oncology. Curr Pharm Des. 2013;19(37):6606-21. PMID: 23621531.

Xu Y, Baiu DC, Sherwood JA, McElreath MR, Qin Y, Lackey KH, Otto M*, Bao Y*. Linker-free conjugation and specific cell targeting of antibody functionalized iron-oxide nanoparticles. J Mater Chem B Mater Biol Med. 2014 Oct 7;2(37):6198-6206. PMID: 26660881. (*co-corresponding authors)

Baiu DC, Artz NS, McElreath MR, Menapace BD, Hernando D, Reeder SB, Grüttner C, Otto M. High specificity targeting and detection of human neuroblastoma using multifunctional anti-GD2 iron-oxide nanoparticles. Nanomedicine (Lond). 2015 Sep 30. [Epub ahead of print]. PMID: 26420448

Marino R, Baiu DC, Bhattacharya S, Titz B, Hebron E, Menapace BD, Singhal S, Eickhoff JC, Asimakopoulos F, Weichert JP, Otto M. Tumor-selective anti-cancer effects of the synthetic alkyl phosphocholine analog CLR1404 in neuroblastoma. Am J Cancer Res. 2015 Oct 15;5(11): 3422-35. PMID: 26807322