Anna Huttenlocher, MD Receives R35 Award from NIHPosted: August 2016
Anna Huttenlocher, MD was recently awarded a Maximizing Investigators' Research Award (R35) from National Institutes of Health/National Institute of General Medical Sciences (NIH-NIGMS) worth over $2.9 million for 5 years, for her research entitled "Cell migration and wound repair." The focus of her research is to understand the basic molecular mechanisms that regulate cell migration and how defects in cell migration contribute to human disease in the context of tissue damage and repair. Understanding how wound repair is orchestrated and integrated at both the single cell and multi-cellular level in the context of different types of damage is the focus of her future research. She will address these questions using optogenetic tools, genomic approaches and advanced imaging in zebrafish and in vitro analysis using human cells.
Mario Otto, MD, PhD, Awarded Grant from Cannonball Kids' Cancer FoundationPosted: August 2016
Mario Otto, MD, PhD, was recently awarded a 3-year grant in the amount of $75,000 from Cannonball Kids' Cancer Foundation for his clinical trial entitled, "TCR-α/β+ and CD19+ depleted KIR/KIR ligand-mismatched Haploidentical Hematopoietic Stem Cell Transplant and Zoledronate for Pediatric Relapsed/Refractory Hematologic Malignancies and High Risk Solid Tumors." Funds from this award will be used in a clinical trial for children with relapsed or refractory hematologic malignancies and high-risk solid tumors (such as rhabdomyosarcoma, neuroblastoma, Ewing sarcoma), utilizing haploidentical hematopoietic stem cell (HSC) transplantation employing a novel, highly selective graft engineering process that removes unwanted cellular components (e.g., α/β T cells and B cells). The CEO, Ashley VanDerMark, and co-founder of Cannonball Kids', Melissa Wiggins, recently visited with Dr. Otto at his laboratory in Madison.
Nydiaris Hernandez-Santos, PhD Receives Burroughs Wellcome Fund Postdoctoral Grant
Nydiaris Hernandez-Santos, PhD, Postdoctoral Fellow in the laboratory of Bruce Klein, MD, has been awarded a $60,000, 3-year Postdoctoral Enrichment Program award from the Burroughs Wellcome Fund. This grant is designed to support the career development activities for underrepresented minority postdoctoral fellows whose training and professional development are guided by mentors committed to helping them advance to stellar careers in biomedical or medical research. Her project, entitled "Role of airway epithelial cells in host defense against pulmonary fungal pathogens," will allow her to test the hypothesis that airway epithelial cells underpin host resistance to fungi.
Research Associate Receives Postdoctoral Fellowship Award from the AHA
Congratulations to Huafeng Wang, PhD, who was recently awarded a Postdoctoral Fellowship from the American Heart Association (AHA) of $110,300 over 2 years. For his project, "New Adjuvants for the Prevention of Cardiovascular Fungal Infections," Dr. Wang, under the mentorship of Marcel Wüethrich, PhD, and Bruce Klein, MD, will identify fungal cell wall ligand(s) that are recognized by Dectin-2 (a C-type lectin receptor) and test their adjuvancy with a safe subunit fungal vaccine. Findings from this project will ultimately advance methods of prevention among cardiovascular patients that are at risk of fungal infection.
James Gern, MD, Receives NIH Supplement
Congratulations to James Gern, MD, who recently was awarded a supplement to his U19 grant award from the National Institutes of Health, National Institute of Allergy and Infectious Diseases (NIH-NIAID) Asthma and Allergic Diseases Cooperative Research Centers (AADCRC). The supplement, in the amount of $143,009, is titled, "A First-in-Human Safety and Dose-Finding Study of New Type-16 Human Rhinovirus (RG-HRV-16) Inoculum in Healthy Volunteers," and will help determine the dose of reverse genetics human rhinovirus 16 (RG-RV16) needed to produce moderate colds in most seronegative individuals, in order lead to testing of new antiviral agents.
Nydiaris Hernandez-Santos, PhD, Receives NIH Diversity Supplement Support
Congratulations to Bruce Klein, MD, and Postdoctoral Fellow Nydiaris Hernandez-Santos, PhD, who have been awarded a Research Supplement to Promote Diversity in Health-Related Research Program from the National Institutes of Health, National Institute of Allergy and Infectious Diseases (NIH-NIAID) in the amount of $173,655. This supplement, as part of Dr. Klein's NIH-NIAID R01 Parent Award entitled, "Molecular pathogenesis of Blastomycosis," provides 2 years of support for Dr. Hernandez-Santos' research.
Daniel Jackson, MD, Part of Consortium Awarded NIH U01 Grant
Researchers from the University of Arizona Health Sciences and seven other institutions, including the UW Department of Pediatrics, were recently awarded a 5-year, $27 million cooperative agreement grant from the National Institutes of Health/National Heart, Lung, and Blood Institute (NIH-NHLBI), for their project entitled, "Oral Bacterial Extracts (ORBEX): Primary Prevention of Asthma and Wheezing in Children." Daniel Jackson, MD, will serve as Site Principal Investigator for the UW's subcontract of over $2 million. For their part, along with Co-Investigator Robert Lemanske, MD, UW Investigators will enroll infants in a clinical study that will evaluate the use of Bronchovaxom (an extract of different bacterial species frequently responsible for respiratory infections) to prevent the development of wheezing in infants at high risk for asthma. More about this project can be found here.
Bikash Pattnaik, PhD, Named M.D. Matthews/Retina Research Foundation Research Professor
Congratulations to Bikash Pattnaik, PhD, who was recently named as the Retina Research Foundation M.D. Matthews Research Professor for 2016-2019. This professorship, with support from the McPherson Eye Research Institute, provides $50,000 annually in support of Dr. Pattnaik's project titled, "Vision loss due to ion-channelopathy."
Jennifer Rehm, MD, Awarded AHEAD Grant from ICTR
Jennifer Rehm, MD, Principal Investigator, and Brittany Allen, MD, Co-Investigator, were recently awarded a $10,000 pilot grant from the Advancing Health Equity and Diversity (AHEAD) program, of the UW Institute for Clinical and Translational Research (ICTR). In their one-year project, titled "Wisconsin Survey of Trans Youth: An Assessment of Resources and Needs," they will survey and conduct focus groups with transgender and gender nonconforming youth (TGNC) to identify community needs and barriers to accessing resources that will serve as an effective platform for future advocacy and resource development.
Krishanu Saha, PhD, Christian Capitini, MD, and David Beebe, PhD, Awarded NSF Grant
Congratulations to Krishanu Saha, Principal Investigator, UW Department of Biomedical Engineering, and Co-Principal Investigators Christian Capitini and David Beebe (Department of Biomedical Engineering), on funding of their National Science Foundation (NSF) proposal entitled, "EAGER BIOMANUFACTURING: A Microscale Testbed to Assay and Manufacture CAR T-Cell Immunotherapies." This 2-year award, in the amount of $300,000, will utilize genetically-engineered human T-cells that express chimeric antigen receptors (CARs) to target cancer associated antigens. The investigators propose to develop a flexible, cost-effective, and scalable microscale co-culture system to isolate functional gene-edited CAR T-cells, expand the fraction, and assess in vivo functionality.