American Family Children's Hospital First in Wisconsin to Offer Newly-Approved CAR-T Leukemia TherapyPosted: August 2017
A unique new therapy for children and young adults with a particular form of leukemia received Food and Drug Administration (FDA) approval on August 30, 2017. American Family Children's Hospital will be one of a handful of certified treatment centers nationwide that offer the treatment, another example of personalized medicine.
Known as chimeric antigen receptor (CAR)-T cell therapy, Kymriah (tisagenlecleucel) was approved to treat acute lymphoblastic leukemia (ALL) that has resisted other treatment or has relapsed a second time. CAR-T cell therapy engineers a child's immune cells (called T-cells) to express a CAR to attach to and eliminate those leukemia cells that express a specific antigen on their cell surface.
The extracted T-cells are sent to a processing center where they are reprogrammed to express the receptor, and then shipped back to American Family Children's Hospital for infusion into the child with relapsed leukemia. The collection of the patient’s T-cells and the infusion of the CAR-T cells are both outpatient procedures.
American Family Children's Hospital was one of a small number of sites that conducted clinical trials for CAR-T cell therapy. One patient has been in "deep remission" for several months, according to site principal investigator Dr. Christian Capitini.
Dr. Elizabeth Cox, Collaborators Receive PCORI Funding to Improve Intimate Partner Violence ScreeningPosted: August 2017
Elizabeth Cox, MD, PhD, in collaboration with partners from the West Virginia Coalition Against Domestic Violence and West Virginia University, recently received approval for a Pipeline to Proposal Tier II award from the Patient-Centered Outcomes Research Institute (PCORI).
This award through PCORI’s Pipeline to Proposal Awards program will support the West Virginia Asking Women About Relationship Experiences (AWARE) Collaborative for Intimate Partner Violence Screening.
Although 7 million U.S. women experience intimate partner violence (IPV), only 3-10% of IPV victims are identified by healthcare professionals due to low screening rates. These rates are especially low in underserved rural areas due to geographic and social isolation.
The West Virginia Coalition Against Domestic Violence will lead this project to transform the healthcare system’s response to intimate partner violence.
Dr. Christine Seroogy and Colleagues Receive UW-Madison Community-University Partnership Award
In recognition of their efforts to improve the health of Plain families in Wisconsin, Christine Seroogy, MD, and colleagues on the Wisconsin Plain Community Project received a 2017 UW-Madison Community-University Partnership Award from Chancellor Rebecca Blank on June 28, 2017.
The award recognizes the work of UW-Madison faculty, staff, students---and their community partners across Wisconsin---as they address pressing public issues in Madison and the region.
Founded in 2012 as a collaboration between the La Farge Medical Clinic (medical director: James DeLine, MD) and Department of Pediatrics faculty, the Wisconsin Plain Community Project aims to improve access to culturally sensitive, high-quality, affordable care for Plain families.
In 2015, Dr. DeLine founded the Center for Special Children as a dedicated space within the clinic for the care of children with genetic conditions. This achievement represented the culmination of the collaboration’s vision.
The collaboration has continued to improve the health of Plain children in Wisconsin, and has also translated to biomedical research projects, informed approaches to medical care for all children, and improved the educational experience of students on campus.
Back row, from left: Murray Katcher, MD (UW Department of Pediatrics); Christine Seroogy, MD (UW Department of Pediatrics); Gregory Rice, MD (UW Department of Pediatrics); Jessica Scott-Schwoerer, MD (UW Department of Pediatrics); Jennifer Laffin, PhD, FACMG (UW Department of Pediatrics); Kyle Bakkum (Vernon Memorial Healthcare CEO)
Front row, from left: Rebecca Blank (UW-Madison chancellor); Mei Baker, MD (UW Department of Pediatrics); Gretchen Spicer (LaFarge Medical Clinic, Vernon Memorial Healthcare); Ellen Wald, MD (UW Department of Pediatrics chair); James DeLine, MD (LaFarge Medical Clinic, Vernon Memorial Healthcare); Ashley Kuhl, MS, CGC (UW Department of Pediatrics); Leslie Orrantia (UW-Madison director of community relations)
Photo by Bryce Richter, University Communications
American Family Children's Hospital Ranks Among U.S. News & World Report Best Hospitals
UW Health's American Family Children's Hospital ranked in the top 50 children's hospitals in six medical and surgical specialties in this year's U.S. News & World Report Best Children's Hospital rankings.
The children's hospital was named one of the top hospitals for:
- Cancer (35)
- Cardiology and heart surgery (49)
- Diabetes and endocrinology (47)
- Gastroenterology and GI surgery (45)
- Nephrology (49)
- Pulmonology (42)
For the first time in the hospital's history, cardiology and heart surgery is ranked among the best programs in the country.
The rankings are based on data collected from 187 U.S. hospitals in the following categories:
- Clinical outcomes
- Level and quality of hospital resources
- Technology and special services
- Delivery of health care
- Expert opinion among pediatric specialists
Only 81 of the 187 surveyed hospitals were ranked in the top 50 in at least one of the 10 specialties.
Drs. Hollman, Ralphe Receive UW Health Physician Excellence Awards
Two University of Wisconsin Department of Pediatrics faculty—Gregory Hollman, MD, and J. Carter Ralphe, MD—recently received UW Health Physician Excellence Awards at a ceremony held June 19, 2017, at the Health Sciences Learning Center.
Dr. Hollman, a professor (CHS) in the Division of Pediatric Critical Care, received a Clinical Practice Physician Excellence Award for his extraordinary commitment to safety and quality patient- and family-centered care. In 1991, he developed the Pediatric Sedation Clinic to serve the needs of children who required MRIs but were unable to hold still for scans; his practice now focuses solely on serving patients in that clinic.
“Patients and families know him better as ‘Dr. Greg,’ and he treats each patient and family member as if they were his own. He is able to gain their trust even in the most difficult situations,” said UW Health Chief Academic Integration Officer Nizar Jarjour, MD, when presenting him with the award.
Dr. Ralphe, an associate professor and chief of the Division of Pediatric Cardiology, received a Regional Services Physician Excellence Award for providing extraordinary outreach care to patients at neighboring health care facilities in Wisconsin and beyond. He has established the greatest number of outreach sites of any pediatric subspecialty throughout Wisconsin and Illinois and has grown the division from 6 to 12 faculty.
“Dr. Ralphe has set the standard for customer service and patient- and family-centered care for all as the division that he leads provides 24-7, 365-day access and consultation services with the highest level of service and professionalism,” said UW Health Chief Executive Office Alan Kaplan, MD, when presenting him with the award.
Drs. Hollman and Ralphe were two of nine physicians overall receiving awards at the ceremony.
In addition, Pediatrics faculty members Paula Cody, MD, David McCulley, MD, and Jeff Sleeth, MD, were also nominated for Physician Excellence awards.
Congratulations to all the winners!
Read more on u-Connect (UW Health employees only).
Dr. Emma Mohr Receives 2017 PIDS Fellowship Award
Congratulations to Emma Mohr, MD, PhD, who has received the 2017-2019 Pediatric Infectious Diseases Fellowship Award for her work in the "Development of a macaque congenital Zika syndrome model: fetal Zika virus tissue distribution and pathology". The goal of the award is to help increase the pool of highly trained pediatric infectious disease clinical scientists and to stimulate scholarly basic and clinical research in areas pertinent to pediatrics. The award funds research in areas of public health/epidemiology, hospital epidemiology, clinical trials of antimicrobials, outcomes research, pharmacokinetics, pathophysiology, molecular pathogenesis, and vaccinology.
Eleven Students and Mentors Chosen by the Shapiro Summer Research Program
The following eleven students and their mentors were recently awarded Shapiro Summer Research Awards. The Shapiro Summer Research Program provides opportunities for more than 60 first-year medical students to participate in eight- to 12-week summer research projects with UW-Madison faculty members. First-year medical students apply at the beginning of each calendar year with basic science, clinical, translational, public health, or health systems projects. Funding for the program comes from the Herman and Gwendolyn Shapiro Foundation, with additional support from SMPH departments and centers and investigator grants. Congratulations to the following faculty and students:
- Ryan Coller, MD, MPH and Mary Ehlenbach, MD - student Allison Nackers: “Evaluation of Preventable Hospitalizations in Children with Medical Complexity”
- James Conway, MD and Stephanie Koning - student Collin Lash: “Evaluating the Intergenerational Effects of Maternal Stressful Life Events on Child Development in Chang Mai Province, Thailand”
- James Conway, MD and Stephanie Koning - student Kaylee Scott: “Assessing the Relationship Between Human Rights Violations and Maternal Health Outcomes in Village Women of Chiang Mai Province, Thailand”
- Michael Kim, MD - student Connie Wu: “Trends in ED Evaluation of Pediatric Patients with Mental Health Complaints”
- Pamela Kling, MD - student Micaela Zywicki: “Improving Diagnosis and Treatment of Iron-Deficiency Anemia in Infants and Toddlers”
- Olachi Mezu-Ndubuisi, MD, OD - student Aaron Anderson: “Investigating the Use of Education on Diet and Medical Co-morbidities to Reduce Cataract Surgery Screening Failure in a Rural Community in Imo State, Nigeria”
- Olachi Mezu-Ndubuisi, MD, OD - student Christina Friedl: “Use of E-learning Applications to Improve Quality of Life in Patients with Cataracts in Imo State, Nigeria”
- Jennifer Rehm, MD and Pamela Kling, MD - student Shoshana Rudin: “Effects of Diet and Inflammation on Disordered Iron Metabolism on Obese Adolescents”
- Kristin Shadman, MD - student Patrick O’Donnell: “Characterizing Feeding Practices for Pediatric Patients on High Flow Nasal Cannula (HFNC)”
- Paul Sondel, MD, PhD - student Ari Stone: “Effect of Innate and Adaptive Immunotherapies on Myeloid-Derived Suppressor Cell Populations in a Mouse Pancreatic Adenocarcinoma Model”
- Sarah Webber, MD - student Camila Khan: “Community Health Worker Led Postpartum Support Group for Latino Mothers and Infants”
MACC Fund Awards 9 Grants
The Midwest Athletes Against Childhood Cancer (MACC) Fund has funded each of nine separate grant requests made by the Departments of Pediatrics and Human Oncology. This marks the 40th year of the MACC Fund, and awards from this year have now brought the overall total of contributions to greater than $60 million to childhood cancer research here in Wisconsin. The grants will fund each project for $100,000 over the next two years. Congratulations to all of the researchers involved!
- Christian Capitini, MD - “Improving Graft-Versus-Leukemia Effects of Ex Vivo Activated NK Cells through JAK/STAT Blockade”
- Ken DeSantes, MD - “Support for Clinical Research Infrastructure”
- Ken DeSantes, MD - “Treatment of Relapsed or Refractory Neuroblastoma with Ex-Vivo Activated and Expanded Haploindentical NK Cells and Hu14.18-IL2”
- Jacquelyn Hank, PhD - “Monitoring of Immune Network Responses in Pediatric Neuroblastoma Patients Treated with Anti-GD2 Immunotherapy”
- Inga Hofmann, MD (with Emery Bresnick, PhD) - “Prognostic Markers and Therapeutic Targets in GATA2-Related Myelodysplastic Syndromes and Leukemia”
- Mario Otto, MD, PhD -“Targeted Molecular Radiotherapy to Improve the Outcomes in Children with Malignant Brain Tumors”
- Mario Otto, MD, PhD (with Dana Baiu PhD)- “Strategies for Improving Recovery of Immune Function following TCRab-depleted Hematopoietic Stem Cell Transplantation”
- Alexander Rakhmilevich, MD, PhD - “Combining Innate and Adaptive Immune Activation for Treatment of Experimental Neuroblastoma”
- Paul Sondel, MD, PhD (with Amy Erbe Gurel, PhD) - “Determining the Influence of KIR/KIR-ligand Genotypes in the Outcome of High-Risk Neuroblastoma Patients Following Anti-GD2 Based Immunotherapy”
James Gern, MD, and Bruce Klein, MD Collaborate on UW2020 Grant
Cameron Currie, PhD, will lead a team of investigators, including Co-PIs Andrew Alexander, PhD; Rozalyn Anderson, PhD; David Andes, MD; Barbara Bendlin, PhD; Christopher Coe, PhD; James Gern, MD; Pamela Herd, PhD; Bruce Klein, MD; Janet Lainhart, MD; Lingjun Li, PhD; Vatsan Raman, PhD; Federico Rey, PhD; Garret Suen, PhD; and Brittany Travers, PhD, to study the Human Microbiome in their recently awarded UW2020 grant entitled, “The Human Microbiome in Health and Disease.” This 2-year WARF Discovery Initiative award leverages two UW-Madison population health cohort studies: the Children’s Respiratory Research and Environment Workgroup (CREW) - led by Dr. Gern - which is tracking the early health and development of about 7,000 children; and the Wisconsin Longitudinal Study (WLS), one of the longest-running investigations of human health. Support for this research was provided by the University of Wisconsin-Madison Office of the Vice Chancellor for Research and Graduate Education with funding from the Wisconsin Alumni Research Foundation. More about the award can be found here: https://research.wisc.edu/funding/uw2020/round-3-projects/the-human-microbiome-in-health-and-disease/
Anna Huttenlocher, MD, Awarded a UW2020 Grant
Congratulations to Anna Huttenlocher, MD, who was awarded a UW2020 grant in the amount of $450,000, for her project entitled, “Engineering leukocytes generated from human iPS cells to treat human disease.” Support for this research was provided by the University of Wisconsin-Madison Office of the Vice Chancellor for Research and Graduate Education with funding from the Wisconsin Alumni Research Foundation. This 2-year WARF Discovery Initiative award, in conjunction with Co-Principal Investigator Igor Slukvin, MD, PhD, will use CRISPR gene editing to generate a panel of iPS cell lines that lead to the production of neutrophil and macrophage populations that are expert killers of microbial pathogens. " More on the award can be found here: https://research.wisc.edu/funding/uw2020/round-3-projects/engineering-leukocytes-generated-from-human-ips-cells-to-treat-human-disease/