Ralphe Lab Researcher Dan Smelter Receives NIH Predoctoral Fellowship

Congratulations to Dan Smelter, predoctoral student in the lab of J. Carter Ralphe, MD, on funding of his Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (F31) from the National Institutes of Health, National Heart, Lung, and Blood Institute (NIH-NHLBI). This 3-year, pre-doctoral fellowship, in the amount of $91,677, is under the sponsorship of Dr. Carter Ralphe. In his project, "The role of the C3 domain of myosin binding protein-C in the pathogenesis of hypertrophic cardiomyopathy," the goal is to determine the effect of two highly prevalent and pathogenic mutations in a contractile protein of the heart, cardiac myosin binding protein-C, and how they lead to disease. The objective of understanding the underlying disease mechanism is to discover new treatment approaches that can prevent the development of the disease.