Krishanu Saha, PhD, Christian Capitini, MD, and David Beebe, PhD, Awarded NSF Grant

Christian M. Capitini, MD
Christian M. Capitini, MD

Congratulations to Krishanu Saha, Principal Investigator, UW Department of Biomedical Engineering, and Co-Principal Investigators Christian Capitini and David Beebe (Department of Biomedical Engineering), on funding of their National Science Foundation (NSF) proposal entitled, "EAGER BIOMANUFACTURING: A Microscale Testbed to Assay and Manufacture CAR T-Cell Immunotherapies." This 2-year award, in the amount of $300,000, will utilize genetically-engineered human T-cells that express chimeric antigen receptors (CARs) to target cancer associated antigens. The investigators propose to develop a flexible, cost-effective, and scalable microscale co-culture system to isolate functional gene-edited CAR T-cells, expand the fraction, and assess in vivo functionality.