Krishanu Saha, PhD, Christian Capitini, MD, and David Beebe, PhD, Awarded NSF Grant

Congratulations to Krishanu Saha, Principal Investigator, UW Department of Biomedical Engineering, and Co-Principal Investigators Christian Capitini and David Beebe (Department of Biomedical Engineering), on funding of their National Science Foundation (NSF) proposal entitled, “EAGER BIOMANUFACTURING: A Microscale Testbed to Assay and Manufacture CAR T-Cell Immunotherapies.” This 2-year award, in the amount of $300,000, will utilize genetically-engineered human T-cells that express chimeric antigen receptors (CARs) to target cancer associated antigens. The investigators propose to develop a flexible, cost-effective, and scalable microscale co-culture system to isolate functional gene-edited CAR T-cells, expand the fraction, and assess in vivo functionality.