Hrissanthi Ikonomidou, MD, PhD, and Diane Puccetti, MD, Awarded ICTR Basic & Clinical Pilot Award

Congratulations to Co-PIs Hrissanthi Ikonomidou, MD, PhD (Neurology), and Diane Puccetti, MD, who were awarded a Basic and Clinical Pilot award from the UW Institute for Clinical and Translational Research (ICTR) for their proposal entitled "Methods to Study Chemotherapy-Related Neurotoxicity in Children." The goal of this 1-year, $49,990 award is to prospectively characterize the evolution of biochemical features of chemotherapy-induced central nervous system (CNS) toxicity in children. Investigators expect that the proposed study will identify early biochemical biomarkers of chemotherapy-induced CNS toxicity in children undergoing treatment for acute lymphoblastic leukemia. These biomarkers can then be used to monitor and help develop strategies to prevent CNS injury in response to chemotherapy.