PROKids Team Receives NIH Funding For PROMIS MetricsPosted: October 2018
The PROKids team, led by Elizabeth Cox, MD PhD, received new NIH funding to develop standard guidance for the use of pediatric PROMIS metrics in ambulatory clinical populations. In collaboration with leadership from prominent child health advocacy organizations and delivery systems nationally, as well as other PROMIS experts and the Institute for Clinical and Translational Research Dissemination and Implementation Program, PROKids will interview healthcare stakeholders to understand, and ultimately address in the guidance, the challenges and opportunities of assessing pediatric population health with patient-reported metrics.
Scott Fites, PhD, Awarded Fellowship from the Hartwell Foundation
Congratulations to Scott Fites, PhD, and his mentor, Bruce Klein, MD, for their recent fellowship award from the Hartwell Foundation. This 2-year grant, titled "Harnessing a long-lived neutrophil to fight systemic fungal infections," awards $100,000 to Dr. Fites to support his research on invasive fungal infections, which take the lives of many vulnerable children-those receiving long-term intravenous catheters, organ-transplants, or a diagnosis of cancer are at exceptionally high risk. A small and poorly-understood population of white blood cells, called neutrophil-dendritic cells, potently kill fungal pathogens, and this project aims to elucidate the signals that cause neutrophil-dendritic cells to emerge. A goal of this project is also to develop adoptive transfer therapy of neutrophil-dendritic cells into pre-clinical models of invasive fungal infection that are receptive to transfer of human cells.
Dr. Neha Patel to Host Symposium on Neurofibromatosis Type 1
On Saturday, October 13, Neha Patel, MD, and her team will be hosting the 2nd annual Neurofibromatosis Type 1 Symposium. This unique event is designed to help patients, parents and siblings better understand NF1, seek answers from the experts, learn about exciting research, meet others and gather resources. There is no cost to attend. Click here for further details.
Facebook, UW School of Medicine and Public Health Team up on Social Media Research
A partnership between Facebook and the University of Wisconsin School of Medicine and Public Health will explore the relationship between teens’ use of digital technologies and their mental and social health.
The research is part of Facebook’s $1 million commitment to work with academics, experts and partners across the industry to further explore this topic. Dr. Megan Moreno, professor and head of the Social Media and Adolescent Health Research Team (SMAHRT) will lead the project at the School of Medicine and Public Health.
“The research will answer foundational and unanswered questions regarding youth, technology, and well-being and will provide guidelines for healthy family digital use,” said Moreno.
Objectives of the study include understanding the relationship between digital technology use and health and well-being of youth; understanding the role of parents in their children’s use of digital technology and well-being; assessing effects of interventions on health and wellbeing; and understanding real-time links between mood and social-media use behaviors.
The study will begin this fall.
Bruce Klein, MD, Awarded Grant from US Geological Survey
Bruce Klein, MD, was recently awarded a 1-year grant for $49,527 from the United States Geological Survey (USGS) National Wildlife Health Center for his project entitled, "The novel method for assessing vaccines against White Nose Syndrome using a mouse model." The overall goal of this project is to determine vaccine antigens that might be useful in protecting bats against white nose syndrome and to test those antigens in an alternative animal model. Congratulations!
Ryan Coller, MD, MPH, Awarded HRSA Subaward with University of Colorado-Denver
Congratulations to Ryan Coller, MD, MPH, Principal Investigator, and Mary Ehlenbach, MD, Co-Investigator, who were recently awarded a subaward for up to 4 years from the University of Colorado-Denver and the Health Resources and Services Administration (HRSA). This project, worth $75,000 of total costs in Year 1, is under the direction of University of Colorado overall PI Christopher Stille, MD, and is entitled "Children and youth with special health care needs research network programs." The Wisconsin team is leading development of 2 projects for the new National Research Network for Children and Youth with Special Health Care Needs (CYSHCNet).
In the first project, Dr. Coller and his team led a multidisciplinary national expert modified-Delphi panel and series of stakeholder focus groups to identify the top priorities for a new National Research Agenda for Children and Youth with Special Health Care Needs.
The second project, “Assessing Confidence at Times of Increased Vulnerability (ACTIV),” is a multisite study involving UW, Harvard, and UCLA that's led by Dr. Coller's team. The goal of this study is to evaluate the feasibility and acceptability of an innovative health information technology tool to collect repeated measures of caregiver confidence of the health of children with medical complexity over time.
Mario Otto, MD, PhD, Receives St. Baldrick's Research Award
Congratulations to Mario Otto, MD, PhD, who was recently awarded a 2018 Research Award from the St. Baldrick's Foundation. This one-year grant, in the amount of $100,000, will support his project entitled, "Improving anti-cancer immune responses to targeted radionuclide therapy." The goal of this project is to combine molecular-targeted radiotherapy with immunomodulatory agents to facilitate radiation-damage induced anti-tumor immune responses. Other UW investigators include Bryan Bednarz, PHD (Medical Physics) and Jamey Weichert, PhD (Radiology).
Dr. Bruce Klein Awarded NIH/NIAID Grant
Congrats to Bruce Klein, MD, on his recent R01 research grant funding from the National Institutes of Health, National Institute of Allergy and Infectious Diseases (NIH/NIAID). His 4-year, $1.85 million project is entitled, "Lung epithelial cell regulation of immunity to inhaled fungi". Our fragile ecosystem has become increasingly plagued by airborne spores from both old and newly emergent fungi due to the excavation of new land and ever-changing climate. Despite this growing public health challenge, little is known about how lung epithelial cells that line the respiratory mucosa sense and manage these repeated spore challenges with each inhaled breath. This project aims to address that gap in knowledge while identifying new avenues for therapeutically targeting early events designed to optimize mucosal immunity to fungi and lung inflammation and powerful gene editing tools to advance the study of lung epithelial cells by the field.
Dr. Ei Terasawa Receives NIH/NICHD Grant
Ei Terasawa, PhD, was recently awarded a 5-year, $2 million research grant from the National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NIH/NICHD) for her project, "Role of neuroestradiol in regulation of the GnRH surge". The overall objective of this proposal is to investigate the regulation of gonadotropin-releasing hormone (GnRH) neurons in the non-human primate. Information obtained from this study will provide a basis for the development of new tools for clinical management of infertility and would lead to a new target for the development of new contraceptive drugs.
Dr. Daniele Gusland Awarded UW Global Health Institute Grant
Congratulations to Daniele Gusland, MD, and her mentors, James Conway, MD, and Dawd Siraj, MD (Department of Medicine), on receiving $25,000 from the University of Wisconsin Global Health Institute for their project, "Etiology and Antimicrobial Resistance Patterns of Neonatal Sepsis in Jimma, Ethiopia (EARNEST)". The team aims to identify the most common organisms responsible for neonatal bacterial infection and estimate the likelihood of successful treatment of these organisms based on their resistance rates to first line antibiotics. This will be done via a 12-month prospective study of 1,000 neonates and young infants admitted to Jimma University Hospital with possible serious bacterial infection (as defined by the WHO danger signs, including poor feeding, seizures, fever, lethargy, hypothermia, tachypnea, and increased work of breathing).