Research

Clinical Trials

Bone Marrow Transplant

TCR-αβ+ and CD19+ Depleted KIR/KIR Ligand-mismatched Haploidentical Hematopoietic Stem Cell Transplant and Zoledronate for Pediatric Relapsed/Refractory Hematologic Malignancies and High Risk Solid Tumors

This phase I trial studies the safety of transplantation with a haploidentical donor (typically Mother or Father) peripheral blood stem cell graft depleted of TCRαβ+ cells (which cause GVHD) and CD19+ cells in conjunction with the immunomodulating drug, Zoledronate, given in the post-transplant period. Zoledronate expands gamma delta T cells, which have anti-tumor properties, speed up immune recovery but do not mediate GVHD.

For more information or questions, please contact us via email at PedsHemOncResearch@lists.wisc.edu or call us at 608-890-8070

Eligible Cancers

Trial treatment diagram

  • Leukemia:  Acute Myeloid  & Acute Lymphoblastic
  • Lymphoma:  Hodgkin & Non-Hodgkin
  • Myelodysplastic Syndrome
  • Myeloproliferative Syndrome
  • Sarcomas:  Rhabdomyosarcoma, Ewing Sarcoma, Osteosarcoma
  • Primitive Neuroectodermal Tumor
  • Neuroblastoma

Ages eligible for study: 7 months to 21 years

Hematologic Malignancies

For more information or questions, please contact us via email at PedsHemOncResearch@lists.wisc.edu or call us at 608-890-8070

Eligible Leukemia and Lymphomas

Leukemia Clinical Trials

Lymphoma Clinical Trials

Solid Tumors

For more information or questions, please contact us via email at PedsHemOncResearch@lists.wisc.edu or call us at 608-890-8070

Eligible Solid Tumors

Sarcomas Other Tumors Other Oncologic Diseases
Ewing Sarcoma
Osteosarcoma
Rhabdomyosarcoma
Neuroblastoma
Wilms Tumor
Hepatoblastoma
Retinoblastoma
Germ Cell Tumors
Endocrine Tumors, including Adrenocortical carcinoma
Thyroid Tumors
Langerhans’ Cell Histiocytosis (LCH)
Hemophagocytic Lymphohistiocytosis (HLH)
Vascular malformations (Hemangiomas and lymphangiomas)
Neurofibromatosis (Malignant Peripheral Nerve Sheath Tumor)

Neuroblastoma Clinical Trials

Sarcoma Clinical Trials

Wilms Tumor Clinical Trials

Late Effects

The Caring for Life Clinic is designed specifically to help the survivors of childhood cancer.

For more information or questions, please contact us via email at PedsHemOncResearch@lists.wisc.edu or call us at 608-890-8070

Clinic Goals

  • Detect and treat problems related to being a childhood cancer survivor
  • Share ongoing research findings with childhood cancer survivors
  • Provide health maintenance education about potential risks and preventive behaviors
  • Provide information to school personnel and employers to meet the special needs of survivors
  • Provide emotional support to both survivors and family members
  • Empower survivors of cancer to advocate for their rights
  • Facilitate transition of medical care to an adult care system

Late Effects Clinical Trials

Neuro-oncology

For more information or questions, please contact us via email at PedsHemOncResearch@lists.wisc.edu or call us at 608-890-8070

Eligible Brain & Spinal Tumors

Brain & Spinal Tumor Clinical Trials