The Division of Allergy, Immunology, and Rheumatology provides state-of-the-art, evidence-based care for children with asthma, allergies, immunologic disorders and rheumatologic diseases.
Our basic and clinical research projects are designed to better understand and find more effective treatments for these diseases.
- James Gern, MD, and Bruce Klein, MD, are part of a team of investigators led by PI Cameron Currie, PhD, on a new, two-year UW2020 grant, “The Human Microbiome in Health and Disease”. The award leverages the Children’s Respiratory Research and Environment Workgroup (CREW), led by Dr. Gern, and the Wisconsin Longitudinal Study (WLS), one of the longest-running investigations of human health.
- The American Society for Cell Biology (ASCB) selected Anna Huttenlocher, MD, as one of its 2017 fellows in recognition of her meritorious efforts to advance cell biology and/or its applications and for her service to ASCB.
Dr. Huttenlocher, in conjunction with co-PI Igor Slukvin, MD, PhD, also received a two-year, $450,000 UW2020 grant, “Engineering leukocytes generated from human iPS cells to treat human disease”. The project will use CRISPR gene editing to generate a panel of iPS cell lines that lead to the production of neutrophil and macrophage populations that are expert killers of microbial pathogens.
Finally, Julia Chini and Meng Lou, two undergraduate students mentored by Dr. Huttenlocher, received 2017-2018 University of Wisconsin Hilldale Undergraduate/Faculty Research Fellowships.
- Daniel Jackson, MD, received funding for a consortium led by Children's Hospital of Boston. The group will initiate an asthma prevention study, "Controlling and Preventing Asthma Severity in Kids (CASK),” which will determine whether omalizumab (anti-IgE) therapy given to 2- and 3-year-old children at high risk for asthma prevents progression to childhood asthma. This seven-year, National Institutes of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID) U01 grant includes a subcontract to UW-Madison totaling over $2 million.
Dr. Jackson was also awarded the Burton Zweiman Memorial Lectureship at the 2017 American Academy of Allergy Asthma and Immunology (AAAAI) annual meeting. This honorary lectureship, "Targeting Viruses in the Primary and Secondary Prevention of Asthma," recognized Dr. Jackson’s outstanding service to the specialty and science of allergy and immunology.
- Allergy and immunology fellow Halie Anderson, MD, (mentor: Daniel Jackson, MD) received the Asthma Diagnosis & Treatment Interest Section Fellow-in-Training Outstanding Abstract Award at the 2017 American Academy of Allergy Asthma and Immunology (AAAAI) annual meeting. Her abstract, "Increased rhinovirus-induced innate immune response in peripheral blood during infancy is associated with improved lung function at school age," was also selected for the meeting’s featured poster session.
- Robert F. Lemanske, Jr., MD, is the co-principal investigator on a National Institutes of Health Clinical and Translational Science Award. The award, which is for $6,237,009 per year for five years, permits the continuation of the UW Institute of Clinical and Translational Research (ICTR). The goal of ICTR is to create an environment that transforms research into a continuum from investigation through discovery and to translation in real-life community practice, thereby linking even the most basic research to practical improvements in human health.
- In recognition of their efforts to improve the health of Plain families in Wisconsin, Christine Seroogy, MD, and colleagues on the Wisconsin Plain Community Project received a 2017 UW-Madison Community-University Partnership Award from Chancellor Rebecca Blank.
Dr. Seroogy also received a $4,000 mini-grant from the Baldwin Wisconsin Idea Endowment for her project, "Blood Lead Level Testing in Plain Newborns."
Professor and Division Chief
Clinical Associate Professor
Clinical Assistant Professor
Clinical Assistant Professor
Anderson HM, Jackson DJ. Microbes, allergic sensitization, and the natural history of asthma. Curr Opin Allergy Clin Immunol. 2017 Apr;17(2):116-122. doi: 10.1097/ACI.0000000000000338. PubMed PMID: 28030377.
Anderson HM, Lemanske RF Jr, Arron JR, Holweg CTJ, Rajamanickam V, Gangnon RE, Gern JE, Jackson DJ. Relationships among aeroallergen sensitization, peripheral blood eosinophils, and periostin in pediatric asthma development. Relationships among aeroallergen sensitization, peripheral blood eosinophils, and periostin in pediatric asthma development. J Allergy Clin Immunol. 2017 Mar;139(3):790-796. doi: 10.1016/j.jaci.2016.05.033. Epub 2016 Jul 5. PubMed PMID: 27484037; PubMed Central PMCID: PMC5215990. **
Anderson HM, Lemanske RF Jr, Evans MD, Gangnon RE, Pappas T, Grindle K, Bochkov YA, Gern JE, Jackson DJ. Assessment of wheezing frequency and viral etiology on childhood and adolescent asthma risk. J Allergy Clin immunol. 2017; 139(2):692-694. NIHMSID: NIHMS814807 PubMed [journal] PMID: 27609657, PMCID: PMC5026309.
Annamalay AA, Jroundi I, Bizzintino J, Khoo SK, Zhang G, Lehmann D, Laing IA, Gern J, Goldblatt J, Mahraoui C, Benmessaoud R, Moraleda C, Bassat Q, Le Souëf P. Rhinovirus C is associated with wheezing and rhinovirus A is associated with pneumonia in hospitalized children in Morocco. J Med Virol. 2017; 89(4):582-588. PubMed [journal] PMID: 27677921.
Barlow-Anacker A, Bochkov Y, Gern J, Seroogy CM. Neonatal immune response to rhinovirus A16 has diminished dendritic cell function and increased B cell activation. PLoS One. 2017 Oct 18;12(10):e0180664. doi: 10.1371/journal.pone.0180664. eCollection 2017. PubMed PMID: 29045416; PubMed Central PMCID: PMC5646756.
Barros-Becker F, Lam PY, Fisher R, Huttenlocher A. Live imaging reveals distinct modes of neutrophil and macrophage migration within interstitial tissues. J Cell Sci. 2017 Nov 15;130(22):3801-3808. doi: 10.1242/jcs.206128. Epub 2017 Sep 28. PubMed PMID: 28972134; PubMed Central PMCID: PMC5702045. *
Bashir H, Grindle K, Vrtis R, Vang F, Kang T, Salazar L, Anderson E, Pappas T, Gangnon R, Evans MD, Jackson DJ, Lemanske RF Jr, Bochkov YA, Gern JE. Association of rhinovirus species with common cold and asthma symptoms and bacterial pathogens. J Allergy Clin Immunol. 2017 Oct 27. pii: S0091-6749(17)31648-2. doi: 10.1016/j.jaci.2017.09.027. [Epub ahead of print] PubMed PMID: 29111214. *
Bjerregaard A, Laing IA, Poulsen N, Backer V, Sverrild A, Fally M, Khoo SK, Barrett L, Baltic S, Thompson PJ, Chidlow G, Sikazwe C, Smith DW, Bochkov YA, Le Souëf P, Porsbjerg C. Characteristics associated with clinical severity and inflammatory phenotype of naturally occurring virus-induced exacerbations of asthma in adults. Respir Med. 2017 Feb;123:34-41. doi: 10.1016/j.rmed.2016.12.010. Epub 2016 Dec 18. PubMed PMID: 28137494; PubMed Central PMCID: PMC5462105.
Bønnelykke K, Coleman AT, Evans MD, Thorsen J, Waage J, Vissing NH, Carlsson CJ, Stokholm J, Chawes BL, Jessen LE, Fischer TK, Bochkov YA, Ober C, Lemanske RF Jr, Jackson DJ, Gern JE, Bisgaard H. CDHR3 genetics and rhinovirus C respiratory illnesses. Am J Respir Crit Care Med. 2017 Nov 9. doi: 10.1164/rccm.201705-1021OC. [Epub ahead of print] PubMed PMID: 29121479. *
Brown KR, Krouse RZ, Calatroni A, Visness CM, Sivaprasad U, Kercsmar CM, Matsui EC, West JB, Makhija MM, Gill MA, Kim H, Kattan M, Pillai D, Gern JE, Busse WW, Togias A, Liu AH, Khurana Hershey GK. Endotypes of difficult-to-control asthma in inner-city African American children. PloS one. 2017; 12(7):e0180778. PubMed [journal] PMID: 28686637, PMCID: PMC5501607.
Co DO, Bordini BJ, Meyers AB, Inglese C. Immune-mediated diseases of the central nervous system: A specificity-focused diagnostic paradigm. Pediatr Clin North Am. 2017 Feb;64(1):57-90. doi: 10.1016/j.pcl.2016.08.005. Review. PubMed PMID: 27894452.
Croteau-Chonka DC, Qiu W, Martinez FD, Strunk RC, Lemanske RF Jr, Liu AH, Gilliland FD, Millstein J, Gauderman WJ, Ober C, Krishnan JA, White SR, Naureckas ET, Nicolae DL, Barnes KC, London SJ, Barraza-Villarreal A, Carey VJ, Weiss ST, Raby BA. Gene expression profiling in blood provides reproducible molecular insights into asthma control. Am J Respir Crit Care Med. 2017 Jan 15;195(2):179-188. doi: 10.1164/rccm.201601-0107OC. PubMed PMID: 27494826; PubMed Central PMCID: PMC5394783.
DeVries A, Wlasiuk G, Miller SJ, Bosco A, Stern DA, Lohman IC, Rothers J, Jones AC, Nicodemus-Johnson J, Vasquez MM, Curtin JA, Simpson A, Custovic A, Jackson DJ, Gern JE, Lemanske RF Jr, Guerra S, Wright AL, Ober C, Halonen M, Vercelli D. Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers. J Allergy Clin Immunol. 2017 Aug;140(2):534-542. doi: 10.1016/j.jaci.2016.10.041. Epub 2016 Dec 21. PubMed PMID: 28011059; PubMed Central PMCID: PMC5479765. **
Esnault S, Bernau K, Torr EE, Bochkov YA, Jarjour NN, Sandbo N. RNA-sequencing analysis of lung primary fibroblast response to eosinophil-degranulation products predicts downstream effects on inflammation, tissue remodeling and lipid metabolism. Respir Res. 2017 Nov 10;18(1):188. doi: 10.1186/s12931-017-0669-8. PubMed PMID: 29126429; PubMed Central PMCID: PMC5681771.
Esquivel A, Busse WW, Calatroni A, Togias AG, Grindle KG, Bochkov YA, Gruchalla RS, Kattan M, Kercsmar CM, Khurana Hershey G, Kim H, Lebeau P, Liu AH, Szefler SJ, Teach SJ, West JB, Wildfire J, Pongracic JA, Gern JE. Effects of omalizumab on rhinovirus infections, illnesses, and exacerbations of asthma. Am J Respir Crit Care Med. 2017 Oct 15;196(8):985-992. doi: 10.1164/rccm.201701-0120OC. PubMed PMID: 28608756; PubMed Central PMCID: PMC5649984.
Fitzpatrick AM, Jackson DJ, Mauger D, Szefler SJ. Reply. J Allergy Clin Immunol. 2017 Oct;140(4):1213. doi: 10.1016/j.jaci.2017.06.018. Epub 2017 Aug 3. PubMed PMID: 28780972. *
Gardeux V, Berghout J, Achour I, Schissler AG, Li Q, Kenost C, Li J, Shang Y, Bosco A, Saner D, Halonen MJ, Jackson DJ, Li H, Martinez FD, Lussier YA. A genome-by-environment interaction classifier for precision medicine: personal transcriptome response to rhinovirus identifies children prone to asthma exacerbations. J Am Med Inform Assoc. 2017 Nov 1;24(6):1116-1126. doi:10.1093/jamia/ocx069. PubMed PMID: 29016970.
Gern JE, Calatroni A, Jaffee KF, Lynn H, Dresen A, Cruikshank WW, Lederman HM, Sampson HA, Shreffler W, Bacharier LB, Gergen PJ, Gold DR, Kattan M, O'Connor GT, Sandel MT, Wood RA, Bloomberg GR. Patterns of immune development in urban preschoolers with recurrent wheeze and/or atopy. J Allergy Clin Immunol. 2017 Jan 13. pii: S0091-6749(17)30030-1. doi: 10.1016/j.jaci.2016.10.052. [Epub ahead of print] PubMed PMID: 28089873; PubMed Central PMCID: PMC5509531. *
Griggs TF, Bochkov YA, Basnet S, Pasic TR, Brockman-Schneider RA, Palmenberg AC, Gern JE. Rhinovirus C targets ciliated airway epithelial cells. Respir Res. 2017 May 4;18(1):84. doi: 10.1186/s12931-017-0567-0. PubMed PMID: 28472984; PubMed Central PMCID: PMC5418766.
Harry O, Schulert GS, Grom AA, Frenck RW Jr, Woltmann JL, Shapiro AH, Smith JA. Cat-scratch disease, a diagnostic consideration for chronic recurrent multifocal osteomyelitis. J Clin Rheumatol. 2017 Dec 12. doi: 10.1097/RHU.0000000000000653. [Epub ahead of print] PubMed PMID: 29239936. *
Huemer K, Squirrell JM, Swader R, LeBert DC, Huttenlocher A, Eliceiri KW. zWEDGI: Wounding and entrapment device for imaging live zebrafish larvae. Zebrafish. 2017; 14(1):42-50. PubMed [journal] PMID: 27676647, PMCID: PMC5312606.
Huemer K, Squirrell JM, Swader R, Pelkey K, LeBert DC, Huttenlocher A, Eliceiri KW. Long-term live imaging device for improved experimental manipulation of zebrafish larvae. J Vis Exp. 2017 Oct 27;(128). doi: 10.3791/56340. PubMed PMID: 29155730.
Jackson DJ, Gern JE, Lemanske RF Jr. Lessons learned from birth cohort studies conducted in diverse environments. J Allergy Clin Immunol. 2017 Feb;139(2):379-386. doi: 10.1016/j.jaci.2016.12.941. Review. PubMed PMID: 28183432; PubMed Central PMCID: PMC5508737.
Jetté ME, Seroogy CM, Thibeault SL. Laryngeal T regulatory cells in the setting of smoking and reflux. The Laryngoscope. 2017; 127(4):882-887. NIHMSID: NIHMS803152 PubMed [journal] PMID: 27653511, PMCID: PMC5360507.
Kakumanu S, Antos N, Szefler SJ, Lemanske RF Jr. Building school health partnerships to improve pediatric asthma care: the School-based Asthma Management Program. Curr Opin Allergy Clin Immunol. 2017 Apr;17(2):160-166. doi: 10.1097/ACI.0000000000000347. PubMed PMID: 28177950.
Kimura Y, Grevich S, Beukelman T, Morgan E, Nigrovic PA, Mieszkalski K, Graham TB, Ibarra M, Ilowite N, Klein-Gitelman M, Onel K, Prahalad S, Punaro M, Ringold S, Toib D, Van Mater H, Weiss JE, Weiss PF, Schanberg LE (Huttenlocher A, collaborator). Pilot study comparing the Childhood Arthritis & Rheumatology Research Alliance (CARRA) systemic juvenile idiopathic arthritis consensus treatment plans. Pediatr Rheumatol Online J. 2017 Apr 11;15(1):23. doi: 10.1186/s12969-017-0157-1. PubMed PMID: 28399931; PubMed Central PMCID: PMC5387287.
Kloepfer KM, Sarsani VK, Poroyko V, Lee WM, Pappas TE, Kang T, Grindle KA, Bochkov YA, Janga SC, Lemanske RF Jr, Gern JE. Community-acquired rhinovirus infection is associated with changes in the airway microbiome. J Allergy Clin Immunol. 2017 Jul;140(1):312-315.e8. doi: 10.1016/j.jaci.2017.01.038. Epub 2017 Mar 19. PubMed PMID: 28327377; PubMed Central PMCID: PMC5496777.
Knox BP, Huttenlocher A, Keller NP. Real-time visualization of immune cell clearance of Aspergillus fumigatus spores and hyphae. Fungal Genet Biol. 2017 Aug;105:52-54. doi: 10.1016/j.fgb.2017.05.005. Epub 2017 May 27. PubMed PMID: 28559109; PubMed Central PMCID: PMC5589445.
Kuhl A, van Calcar S, Baker M, Seroogy CM, Rice G, Scott Schwoerer J. Development of carrier testing for common inborn errors of metabolism in the Wisconsin Plain population. Genet Med. 2017 Mar;19(3):352-356. doi: 10.1038/gim.2016.104. Epub 2016 Aug 11. PubMed PMID: 27513192. **
Lang JE, Fitzpatrick AM, Mauger DT, Guilbert TW, Jackson DJ, Lemanske RF Jr, Martinez FD, Strunk RC, Zeiger RS, Phipatanakul W, Bacharier LB, Pongracic JA, Holguin F, Cabana MD, Covar RA, Raissy HH, Tang M, Szefler SJ; National Institutes of Health/National Heart, Lung and Blood Institute AsthmaNet. Overweight/obesity status in preschool children associates with worse asthma but robust improvement on inhaled corticosteroids. J Allergy Clin Immunol. 2017 Dec 8. pii: S0091-6749(17)31738-4. doi: 10.1016/j.jaci.2017.09.043. [Epub ahead of print] PubMed PMID: 29273557. *
Liu Y, Ye Z, Li X, Anderson JL, Khan M, DaSilva D, Baron M, Wilson D, Bocoun V, Ivacic LC, Schrodi SJ, Smith JA. Genetic and functional associations with decreased anti-inflammatory tumor necrosis factor alpha induced protein 3 in macrophages from subjects with axial spondyloarthritis. Front Immunol. 2017 Jul 24;8:860. doi: 10.3389/fimmu.2017.00860. eCollection 2017. PubMed PMID: 28791018; PubMed Central PMCID: PMC5523649.
Liu YP, Rajamanikham V, Baron M, Patel S, Mathur SK, Schwantes EA, Ober C, Jackson DJ, Gern JE, Lemanske RF Jr, Smith JA. Association of ORMDL3 with rhinovirus-induced endoplasmic reticulum stress and type I Interferon responses in human leucocytes. Clin Exp Allergy. 2017 Mar;47(3):371-382. doi: 10.1111/cea.12903. PubMed PMID: 28192616; PubMed Central PMCID: PMC5376287.
Mickel CF, Shanovich KK, Evans MD, Jackson DJ. Evaluation of a school-based asthma education protocol. J Sch Nurs. 2017 Jun;33(3):189-197. doi: 10.1177/1059840516659912. Epub 2016 Jul 22. PubMed PMID: 27450449. **
Muraro A, Lemanske RF Jr, Castells M, Torres MJ, Khan D, Simon HU, Bindslev-Jensen C, Burks W, Poulsen LK, Sampson HA, Worm M, Nadeau KC. Precision medicine in allergic disease-food allergy, drug allergy, and anaphylaxis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma and Immunology. Allergy. 2017; 72(7):1006-1021. PubMed [journal] PMID: 28122115.
Oberle EJ, Bayer ML, Chiu YE, Co DO. How often are pediatric patients with clinically amyopathic dermatomyositis truly amyopathic? Pediatr Dermatol. 2017 Jan;34(1):50-57. doi: 10.1111/pde.13013. Epub 2016 Nov 4. PubMed PMID: 27813167.
Phillippi K, Hoeltzel M, Byun Robinson A, Kim S (Huttenlocher A, collaborator). Race, income, and disease outcomes in juvenile dermatomyositis. J Pediatr. 2017 May;184:38-44.e1. doi: 10.1016/j.jpeds.2017.01.046. Epub 2017 Mar 3. PubMed PMID: 28410093; PubMed Central PMCID: PMC5410644. *
Powell D, Tauzin S, Hind LE, Deng Q, Beebe DJ, Huttenlocher A. Chemokine signaling and the regulation of bidirectional leukocyte migration in interstitial tissues. Cell Rep. 2017 May 23;19(8):1572-1585. doi: 10.1016/j.celrep.2017.04.078. PubMed PMID: 28538177; PubMed Central PMCID: PMC5505660.
Prince BT, Devonshire AL, Erickson KA, Bergerson J, Fuleihan D, Szychlinski C, Schleimer RP, Bryce PJ, Singh AM. Regulatory T-cell populations in children are affected by age and food allergy diagnosis. J Allergy Clin Immunol. 2017 Oct;140(4):1194-1196.e16. doi: 10.1016/j.jaci.2017.04.039. Epub 2017 May 23. PubMed PMID: 28549988; PubMed Central PMCID: PMC5777506.
Ramratnam SK, Visness CM, Jaffee KF, Bloomberg GR, Kattan M, Sandel MT, Wood RA, Gern JE, Wright RJ. Relationships among maternal stress and depression, Type 2 responses, and recurrent wheezing at age 3 years in low-income urban families. Am J Respir Crit Care Med. 2017; 195(5):674-681. PubMed [journal] PMID: 27654103, PMCID: PMC5363974.
Rubner FJ, Jackson DJ, Evans MD, Gangnon RE, Tisler CJ, Pappas TE, Gern JE, Lemanske RF Jr. Early life rhinovirus wheezing, allergic sensitization, and asthma risk at adolescence. J Allergy Clin Immunol. 2017;139(2):501-507. NIHMSID: NIHMS781627 PubMed [journal] PMID: 27312820, PMCID:PMC5104680.
Schwantes EA, Evans MD, Cuskey A, Burford A, Smith JA, Lemanske RF Jr, Jarjour NN, Mathur SK. Elevated fractional exhaled nitric oxide and blood eosinophil counts are associated with a 17q21 asthma risk allele in adult subjects. J Asthma Allergy. 2017 Dec 19;11:1-9. doi: 10.2147/JAA.S149183. eCollection 2018. PubMed PMID: 29296089; PubMed Central PMCID: PMC5741070.
Turunen R, Vuorinen T, Bochkov Y, Gern J, Jartti T. Clinical and virus surveillance after the first wheezing episode: Special reference to rhinovirus A and C species. Pediatr Infect Dis J. 2017 Jun;36(6):539-544. doi: 10.1097/INF.0000000000001495. PubMed PMID: 28027280; PubMed Central PMCID: PMC5472222.
Waqas SFH, Hoang AC, Lin YT, Ampem G, Azegrouz H, Balogh L, Thuróczy J, Chen JC, Gerling IC, Nam S, Lim JS, Martinez-Ibañez J, Real JT, Paschke S, Quillet R, Ayachi S, Simonin F, Schneider EM, Brinkman JA, Lamming DW, Seroogy CM, Röszer T. Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages. J Clin Invest. 2017 Sep 1;127(9):3559. doi: 10.1172/JCI95841. Epub 2017 Jul 31. PubMed PMID: 28758905.
Zisman D, Gladman DD, Stoll ML, Strand V, Lavi I, Hsu JJ, Mellins ED (Huttenlocher A, collaborator). The juvenile psoriatic arthritis cohort in the CARRA registry: Clinical characteristics, classification, and outcomes. J Rheumatol. 2017 Mar;44(3):342-351. doi: 10.3899/jrheum.160717. Epub 2017 Feb 1. PubMed PMID: 28148698.
*ePub only; no print citation available when report was compiled
** Publication had previously appeared in 2016 report as an ePub
Our faculty were principal investigators and/or co-investigators on the following grants during calendar year 2017.
|Bochkov, Yury A (PI)||DHHS, PHS, National Institutes of Health & University of California-San Diego||Polyvalent rhinovirus C vaccine|
|Co, Dominic (co-PI) with Syverson, Grant D||Arthritis Foundation||Development of a CME online education program|
|Gern, James E (PI) with Bochkov, Yury A (co-I)||DHHS, PHS, National Institutes of Health & Children's Hospital of Boston||Viral persistence & the microbiome in bronchiolitis and risk of recurrent wheeze|
|Gern, James E (PI) with Jackson, Daniel J, Lemanske Robert F and Seroogy, Christine A (co-Is)||DHHS, PHS, National Institutes of Health||Children's respiratory research and environment workgroup (CREW)|
|Gern, James E (PI) with Seroogy, Christine A (co-I) and Bochkov, Yury A (Project II Co-Investigator & Virology Core Leader)||DHHS, PHS, National Institutes of Health||Mechanisms and environmental determinants of rhinovirus illness severity|
|Gern, James E (PI) with Lemanske, Robert F (co-Director)||DHHS, PHS, National Institutes of Health||Wisconsin allergy research training (WISCART) program|
|Gern, James E (PI) with Bochkov, Yury A (co-I)||DHHS, PHS, National Institutes of Health & Massachusetts General Hospital||Infant specific-IgE, rhinovirus-C bronchiolitis, and incident asthma in MARC-35|
|Gern, James E (co-MPI) with Busse, William (co-MPI); Jackson, Daniel (co-I); and Bochkov, Yury (Senior Scientist)||DHHS, PHS, National Institutes of Health||Inner City Asthma Consortium 3 (ICAC3)|
|Gern, James E (co-I) with Sun, Xin (PI) and McCulley, David (co-I)||UWF - Wisconsin Partnership - MERC||Zooming in on childhood asthma: disease causality and personalized medicine|
|Huttenlocher, Anna (PI)||American Heart Association Greater Midwest||Mechanisms of macrophage-dependent neutrophil reverse migration during tissue damage|
|Huttenlocher, Anna (PI)||Cancer Research Institute||Role of innate immune system in fibrolamellar hepatocellular carcinoma - Fhl2 as a putative molecular target|
|Huttenlocher, Anna (PI)||Cancer Research Institute||The role of neutrophils and CXCL8-CXCR1/2 signaling in glioblastoma cell invasion|
|Huttenlocher, Anna (PI)||DHHS, PHS, National Institutes of Health||Adhesive regulation during cell migration|
|Huttenlocher, Anna (PI)||DHHS, PHS, National Institutes of Health||Cell migration and wound repair|
|Huttenlocher, Anna (PI)||DHHS, PHS, National Institutes of Health||Integrated training for physician scientists|
|Huttenlocher, Anna (PI)||Duke University||CARRA registry|
|Huttenlocher, Anna (PI)||European Molecular Biology Organization||In vivo study of the interaction between the transcriptional coactivator FHL2 and the actin cytoskeletal protein mAbp1 during invasive cell migration|
|Huttenlocher, Anna (PI)||UWF - University of Wisconsin Foundation||MSTP student travel award|
|Huttenlocher, Anna (PI)||Vilas (William F) Trust Estate||Vilas distinguished achievement professorship|
|Huttenlocher, Anna (PI)||Wisconsin Alumni Research Foundation||Engineering leukocytes generated from human iPS cells to treat human disease|
|Huttenlocher, Anna (co-PI) with Beebe, David (PI)||DHHS, PHS, National Institutes of Health||Understanding cell migration through microscale in vitro models|
|Huttenlocher, Anna (co-I) with Keller, Nancy (PI)||National Science Foundation||ERFI-MIKS proposal: microfluidic-based screening of multi-kingdom microbial communication molecules|
|Jackson, Daniel J (PI) with Lemanske, Robert F (co-I)||DHHS, PHS, National Institutes of Health & Children's Hospital of Boston||Controlling and preventing asthma progression in kids (CASK)|
|Jackson, Daniel J (co-MPI) with Lemanske, Robert F (co-MPI); Gern, James E (Project II PI); Seroogy, Christine M; Smith Judith A (co-Is); Bochkov, Yury (Microbiology Core Leader)||DHHS, PHS, National Institutes of Health||COAST|
|Jackson, Daniel J (PI)||Glaxosmithkline||A long-term access programme for subjects with severe asthma who participated in a GSK-sponsored mepolizumab clinical study|
|Jackson, Daniel J (PI)||Glaxosmithkline||An open-label study to characterize the pharmacokinetics and pharmacodynamics of mepolizumab administered subcutaneously in children from 6 to 11 years of age with severe eosinophilic asthma - 200363|
|Jackson, Daniel J (PI)||Glaxosmithkline||Mechanisms underlying asthma exacerbations prevented with & persistent despite immune-based therapy: A systems approach (MUPPITS-2)|
|Jackson, Daniel J (PI)||DHHS, PHS, National Institutes of Health & Pennsylvania State University||AsthmaNet, April-Ocelot viral determinations and bacterial detection|
|Jackson, Daniel J (PI)||DHHS, PHS, National Institutes of Health & Pennsylvania State University||AsthmaNet, Infant-Avica nasal bacterial and viral detection|
|Jackson, Daniel J (PI)||DHHS, PHS, National Institutes of Health & Pennsylvania State University||AsthmaNet, STICS (biome study)|
|Jackson, Daniel J (PI)||DHHS, PHS, National Institutes of Health & Pennsylvania State University||AsthmaNet, STICS (main study)|
|Jackson, Daniel J (PI) with Lemanske, Robert F (co-I)||DHHS, PHS, National Institutes of Health & University of Arizona||ORBEX|
|Jackson, Daniel J (co-I) with Denlinger, Loren; Jarjour, Nizar; and Krishnan, Jerry (co-MPIs)||DHHS, PHS, National Institutes of Health||The Great Lakes PrecISE Partnership|
|Lemanske, Robert F and Sorkness, Christine (co-MPIs); Jackson, Daniel J (co-I)||DHHS, PHS, National Institutes of Health & Pennsylvania State University||AsthmaNet|
|Lemanske, Robert F (PI)||DHHS, PHS, National Institutes of Health & University Of Colorado - Denver||Improved prediction of response to asthma medication using small molecules|
|Lemanske, Robert F (co-PI) with Drezner, Marc (co-PI) and Seroogy, Christine A (Assistant Director, Pediatrics, of the UW ICTR Clinical Research Unit)||DHHS, PHS, National Institutes of Health||UW Institute for Clinical & Translational Research (UW-ICTR)|
|Seroogy, Christine M (PI)||DHHS, PHS, National Institutes of Health||The role of the anergy-related E3 ubiquiting ligase, GRAIL, in tumor immune evasion|
|Seroogy, Christine M (PI)||DHHS, PHS, National Institutes of Health & Northwestern University||Lipid regulation of the development of responsiveness to allergen in neonates and infants|
|Seroogy, Christine M (PI) with Wald, Ellen (co-I) and Baker, Mei Wang; Laffin, Jennifer; Rice, Gregory; Scott Schwoerer, Jessica (collaborators)||UWF - Wisconsin Partnership - MERC||Improved health care delivery to Wisconsin Amish infants|
|Singh, Anne Marie (PI)||DHHS, PHS, National Institutes of Health||Staphylococcus aureus and regulatory T cells in oral immunotherapy|
|Smith, Judith A (PI)||DHHS, PHS, National Institutes of Health||Regulation of human immune function by 17q21 asthma risk polymorphism|
|Smith, Judith A (PI)||DHHS, PHS, National Institutes of Health||The role of the unfolded protein response in brucella melitensis replication|
|Smith, Judith A (PI)||DHHS, PHS, National Institutes of Health & Federal University of Minas Gerais||Brucella survival strategy requiers endoplasmic reticulum restructuing and interferes with innate immunity|
|Smith, Judith A (PI)||Wisconsin Alumni Research Foundation||Development of IL-17 targeting small molecule therapeutics for autoimmune diseases|
|Smith, Judith A (PI)||Wisconsin Alumni Research Foundation||Immunogenetics of axial spondyloarthritis|
|Smith, Judith A (co-PI) with Splitter, Gary and Harms, Jerome (co-PIs)||DHHS, PHS, National Institutes of Health||Brucella epitope recognition by CD8+ T cells|