The Division of Infectious Disease cares for children with common, complex or potentially life-threatening infectious diseases and illnesses.
Research interests include international health, immunization efficacy, vaccine preventable disease epidemiology and policy, respiratory tract infections, urinary tract infections and fungal infections.
- James H. Conway, MD, traveled to Washington, DC, to advocate for a new, bipartisan House resolution ensuring that children in poor countries have access to vaccines and immunizations through U.S. support of the Global Alliance for Vaccines and Immunisation (GAVI).
- Fellow James "Muse" Davis, MD, received a fellowship award from the Pediatric Infectious Diseases Society for his project, "Understanding Fungal Morphogenesis and Dissemination Using In Vivo Imaging of a Larval Zebrafish Model."
- Sheryl Henderson, MD, PhD, received a grant from the Wisconsin Children and Youth with Special Health Care Needs (funded by the Maternal Child Health Title V Block Grant and sponsored by the Waisman Center) to develop policy and tools to transition youth in the adolescent program of the UW HIV Comprehensive Care Clinic from adolescent to adult care.
- Bruce Klein, MD, is part of a team of UW-Madison researchers who have received a five-year, $16 million grant from the National Institutes of Health to find new sources of antibiotics to combat the rising number of deadly antibiotic-resistant infections. He also received the following grant awards:
- A two-year, $420,750 R21 award from the National Institutes of Health–National Institute of Allergy and Infectious Diseases (NIH-NIAID) for "Molecular Pathogenesis and Blastomyces Adherence."
- A three-year, $500,000 grant from the Wisconsin Partnership Program’s Collaborative Health Sciences Program to study blastomycosis infection among Hmong-ancestry populations
- A three-year, $275,860 grant from the US Geological Survey for "Oral Vaccines and Delivery Methods for Controlling Disease in Bats" (with co-PI Jorge Osorio, DVM, MS, PhD)
- Stephanie Lawry, a research assistant in the laboratory of Bruce Klein, MD, received a two-year, $52,000 Predoctoral Fellowship Award from the American Heart Association for her project, "Group III Hybrid Histidine Kinases: A Novel Drug Target for the Treatment of Cardiac Fungal Infections.”
Professor and Division Chief
Associate Professor (CHS)
Assistant Professor (CHS)
DeMuri GP, Wald ER. Acute bacterial sinusitis. In: Chonmaitree T, Patel JA. Contemporary Approaches to Upper Respiratory Tract Infections. London: Future Medicine; 2014.
DeMuri, GP, Wald ER. Sinusitis. In: Mandell GL, Dolin R, Blaser MJ, eds. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 8th ed. Philadelphia, PA: Elsevier Saunders; 2014.
Hung CY, Jiménez-Alzate Mdel P, Gonzalez A, Wüethrich M, Klein BS, Cole GT. Interleukin-1 receptor but not Toll-like receptor 2 is essential for MyD88-dependent Th17 immunity to Coccidioides infection. Infect Immun. 2014 May;82(5):2106-14. Epub 2014 Mar 10. PMID: 24614655.
Krajaejun T, Lerksuthirat T, Garg G, Lowhnoo T, Yingyong W, Khositnithikul R, Tangphatsornruang S, Suriyaphol P, Ranganathan S, Sullivan TD. Transcriptome analysis reveals pathogenicity and evolutionary history of the pathogenic oomycete Pythium insidiosum. Fungal Biol. 2014 Jul;118(7):640-53. Epub 2014 Feb 6. PMID: 25088078.
Koepke R, Eickhoff JC, Ayele RA, Petit AB, Schauer SL, Hopfensperger DJ, Conway JH, Davis JP. Estimating the effectiveness of tetanus-diphtheria-acellular pertussis vaccine (Tdap) for preventing pertussis: evidence of rapidly waning immunity and difference in effectiveness by Tdap brand. J Infect Dis. 2014 Sep 15;210(6):942-53. Epub 2014 Jun 5. PMID: 24903664.
Koepke R, Eickhoff JC, Ayele RA, Petit AB, Schauer SL, Hopfensperger DJ, Conway JH, Davis JP. Reply to decker et Al. J Infect Dis. 2015 Feb 1;211(3):498-9. PMID: 25156559.
Lohnoo T, Jongruja N, Rujirawat T, Yingyon W, Lerksuthirat T, Nampoon U, Kumsang Y, Onpaew P, Chongtrakool P, Keeratijarut A, Brandhorst TT, Krajaejun T. Efficiency comparison of three methods for extracting genomic DNA of the pathogenic oomycete Pythium insidiosum. J Med Assoc Thai. 2014 Mar;97(3):342-8. PMID: 25123015.
Nanjappa SG, Klein BS. Vaccine immunity against fungal infections. Curr Opin Immunol. 2014 Jun;28:27-33. Epub 2014 Mar 3. Review. PMID: 24583636.
Nelson RW, Beisang D, Tubo NJ, Dileepan T, Wiesner DL, Nielsen K, Wüethrich M, Klein BS, Kotov DI, Spanier JA, Fife BT, Moon JJ, Jenkins MK. T-cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity. Immunity. 2014 Dec 25. [Epub ahead of print]. PMID: 25601203.
Peters AT, Spector S, Hsu J, Hamilos DL, Baroody FM, Chandra RK, Grammer LC, Kennedy DW, Cohen NA, Kaliner MA, Wald ER, Karagianis A, Slavin RG. Diagnosis and management of rhinosinusitis: a practice parameter update. Ann Allergy Asthma Immunol. 2014 Oct;113(4):347-85. PMID: 25256029.
Shah AP, Cobb BT, Lower DR, Shaikh N, Rasmussen J, Hoberman A, Wald ER, Rosendorff A, Hickey RW. Enhanced versus automated urinalysis for screening of urinary tract infections in children in the emergency department. Pediatr Infect Dis J. 2014 Mar;33(3):272-5. PMID: 24263219.
Shaikh N, Wald ER. Decongestants, antihistamines and nasal irrigation for acute sinusitis in children. Cochrane Database Syst Rev. 2014 Oct. 27;10:CD007909. PMID: 25347280.
St Clair NE, Fischer PR, Hagen SA, Kuzminski J, Al-Nimr A, Pitt MB, Schubert C, Umphrey L, Warrick S, Conway JH. Midwest Consortium of Global Child Health Educators: Local collaboration to strengthen global education. Ann Global Health. 2014;80(3):178.
Verma A, Wüethrich M, Deepe GS, Klein BS. Adaptive immunity to fungi. Cold Spring Harb Perspect Med. 2014 Nov 6;5(3). Review. PMID: 25377140.
Wang H, LeBert V, Hung CY, Galles K, Saijo S, Lin X, Cole GT, Klein BS, Wüethrich M. C-type lectin receptors differentially induce th17 cells and vaccine immunity to the endemic mycosis of North America. J Immunol. 2014 Feb 1;192(3):1107-19. Epub 2014 Jan 3. PMID: 24391211.
Wilson MR, Naccache SN, Samayoa E, Biagtan M, Bashir H, Yu G, Salamat SM, Somasekar S, Federman S, Miller S, Sokolic R, Garabedian E, Candotti F, Buckley RH, Reed KD, Meyer TL, Seroogy CM, Galloway R, Henderson SL, Gern JE, DeRisi JL, Chiu CY. Actionable diagnosis of neuroleptospirosis by next-generation sequencing. N Engl J Med. 2014 Jun 19;370(25):2408-17. Epub 2014 Jun 4. PMID: 24896819.
Our faculty were principal investigators and/or co-investigators on the following grants during calendar year 2014.
|Conway, James H (PI)||Sanofi Pasteur||Surveillance for Rates of Pertussis Disease Among Persons birth through 59 Months of Age Receiving Pentacel or Other Pertussis Vaccines|
|Conway, James H (co-I) with
Temte, Jon (PI)
|DHHS, PHS, Centers for Disease Control||ORCHARDS: ORegon CHild Absenteeism due to Respiratory Disease Study|
|Henderson, Sheryl L (PI)||Wisconsin Department of Health Services||HIV/AIDS Comprehensive Care Program|
|Klein, Bruce S (PI)||Wisconsin Alumni Research Foundation||Targeting Hybrid Histidine Kinase for Broad-Spectrum Antifungal Therapy|
|Klein, Bruce S (PI)||Wisconsin Alumni Research Foundation||Anti-Fungal Drug Discovery|
|Klein, Bruce S (PI)
Wüethrich, Marcel (co-I)
|DHHS, PHS, National Institutes of Health||Mechanisms of Anti-Fungal Vaccine Immunity|
|Klein, Bruce S (PI)||DHHS, PHS, National Institutes of Health||Tracking Anti-Fungal CD4+ T Cells In Vivo|
|Klein, Bruce S (PI)||American Heart Association Greater Midwest Affiliate||Group III Hybrid Histidine Kinases: A Novel Drug Target for the Treatment of Cardiac Fungal Infections (S. Lawry)|
|Klein, Bruce S (PI)||Pediatric Infectious Diseases Society||Understanding Fungal Morphogenesis and Dissemination Using In Vivo Imaging of a Larval Zebrafish Model (J.M. Davis)|
|Klein, Bruce S (PI)||Wisconsin Alumni Research Foundation||Strategies for Assessing and Inducing Immunity to Life-Threatening Fungal Infections|
|Klein, Bruce S (PI)||Wisconsin Alumni Research Foundation||Attend the Gordon Research Conference "Immunology of Fungal Infections" in Galveston, TX|
|Klein, Bruce S (PI)||DHHS, PHS, National Institutes of Health||T32 - Microbes in Health and Disease|
|Klein, Bruce S (PI)||Lucigen||CLIA-waived Point of Care Tests for Infection by Coccidioides, Blastomyces and Histoplasma.|
|Klein, Bruce S (PI)||DHHS, PHS, National Institutes of Health||Molecular Pathogenesis and Blastomyces Adherence|
|Klein, Bruce S (PI)||UWF - Wisconsin Partnership Program MERC||Wisconsin Center for Infectious Diseases|
|Klein, Bruce S (co-PI with
|US Geological Survey||Oral Vaccines and Delivery Methods for Controlling Disease in Bats|
|Klein, Bruce S (core B co-leader) with
Andes, David (PI)
|National Institutes of Health||Anti-Fungal Drug Discovery|
|Wald, Ellen R (PI)||Hoffmann-Laroche, Inc.||BP28947 - "A Screening Protocol to Assess Adult and Adolescent Individuals with Down Syndrome for Eligibility to Participate in an Upcoming Study to Evaluate the Efficacy, Safety and Tolerability of RO5186582"|
|Wald, Ellen R (PI) with
DeMuri, Gregory P and
Gern, James E (co-Is)
|DHHS, PHS, National Institutes of Health||Sinusitis in Children and the Nasopharyngeal Microbiome|
|Wald, Ellen R (PI)||DHHS, PHS, National Institutes of Health||An Interactive Web-Based Intervention to Achieve Healthy Weight in Young Children|
|Wald, Ellen R (PI)||Glaxosmithkline||GSK 112957 (HIB-097)|
|Wald, Ellen R (PI)||Cubist Pharmaceuticals, Inc.||CUBEXA-01: A Multicenter, Randomized, Double-Blinded Comparative Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Ceftaroline or Daptomycin Versus Active Comparator in Pediatric Subjects With Acute Hematogenous Osteomyelitis Due to Gram-Positive Organisms|
|Wald, Ellen R (PI)||Glaxosmithkline||GSK MMR0160|
|Wald, Ellen R (PI)
DeMuri, Gregory P (co-I)
|Thrasher Research Fund||Short (5 days) versus Long (14 days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in Children|
|Wald, Ellen R (PI)||Glaxosmithkline||Immunogenicity and Safety Study of GSK Biologicals 'Infanrix hexa' at 2, 4 and 6 Months of Age in Healthy Infants.|
|Wald, Ellen R (co-I) with
Baker, Mei Wang;
Laffin, Jennifer J;
Jessica A (collaborators) and
Seroogy, Christine (PI)
|Wisconsin Partnership Program||Improved Health Care Delivery to Wisconsin Amish Infants|
|Wüethrich, Marcel (PI)
Klein, Bruce S (co-I)
|DHHS, PHS, National Institutes of Health||Regulation of Vaccine-Induced Anti-Fungal T17 Cells|