Division Highlights - Critical Care

The Division of Pediatric Critical Care Medicine delivers comprehensive, state-of-the-art care to critically ill children admitted to American Family Children’s Hospital.

Our scholarly endeavors include advocacy, medical education, clinical and basic science research, and global health.

2013 Highlights

  • Melissa Bates, PhD, a scientist in the lab of Marlowe Eldridge, MD, MSME, received the "Caroline tum Suden Professional Opportunity Award" by the American Physiological Society (APS). The award provides support for junior physiologists to attend and participate in the APS's annual Experimental Biology meeting.
  • Marlowe Eldridge, MD, received a three-year grant of $1.4 million from the U.S. Navy Experimental Diving Unit for his project, “Development of Decompression and Oxygen Pre-Breathe Schedules for Submarine Escape and Rescue using UW Sheep Model.”
  • Peter Ferrazzano, MD, received a five-year, $960,000 National Institutes of Health–National Institute of Neurological Disorders and Stroke (NIH-NINDS) Mentored Clinical Scientist Research Career Development Award (K08) for his project “Age-Dependent Microglial Responses in Hypoxia-Ischemia.”
  • Lynne Sears, MS, RN, CPNP, received the UW Health Advance Practice Provider Excellence Award, which recognizes UW Health nurse practitioners and physician assistants who demonstrate outstanding clinical practice, teaching and leadership.

Faculty


Marlowe W. Eldridge, MD

Associate Professor and
Division Chief

Juan P. Boriosi, MD

Assistant Professor (CHS)

Tom Brazelton, MD, MPH

Associate Professor (CHS)

Pelin Cengiz, MD

Assistant Professor (CHS)

Melissa A. Cercone, MD

Assistant Professor (CHS)

Peter A. Ferrazzano, MD

Assistant Professor (CHS)

Scott A. Hagen, MD

Associate Professor (CHS)

Gregory A. Hollman, MD

Professor (CHS)

Sushant Srinivasan, MD

Assistant Professor (CHS)

Michael Wilhelm, MD

Assistant Professor

   

Recent Publications

Bates ML, Pillers DA, Palta M, Farrell ET, Eldridge MW. Ventilatory control in infants, children, and adults with bronchopulmonary dysplasia. Respir Physiol Neurobiol. 2013 Nov 1;189(2):329-37. Epub 2013 Jul 22. PMID: 23886637.

Bhatia R, Rowley HD, Mosher JC, Alsheik NH, Aagaard-Kienitz B, Diamond CD, Iskandar BJ, Peters A, Boriosi JP, Patel NJ. Extensive sinovenous thrombosis and hemorrhagic infarction during therapy for T-cell acute lymphoblastic leukemia. Pediatr Emerg Care. 2013 Jan;29(1):93-7. PMID: 23283276.

Brazelton TB. Pediatrics. In: Mistovich JJ, Karren KJ, Hafen B, eds. Prehospital Emergency Care, 10th ed. Upper Saddle River, NJ: Pearson/Prentice Hall, 2013.

Egan KR, Srinivasan S, Hagen SA, Anagnostopoulos PV. Late manifestation of coarctation of the aorta after arterial switch operation for D-transposition of the great arteries with intact ventricular septum. Pediatr Cardiol. 2013 Mar;34(3):729-32. PMID: 22562776.

Ferrazzano P, Chanana V, Uluc K, Fidan E, Akture E, Kintner DB, Cengiz P, Sun D. Age-dependent microglial activation in immature brains after hypoxia-ischemia. CNS Neurol Disord Drug Targets. 2013 May 1;12(3):338-49. PMID: 23469850.

Hollman GA, Banks DM, Berkenbosch JW, Boswinkel JP, Eickhoff JC, Fagin D, Hagen SA, Hales RL, Houck CS, Kaur T, Kost S, Lowrie L, Nishisaki A, Scherrer PD, Stephenson L, Stormorken A, Cravero JP. Development, implementation, and initial participant feedback of a pediatric sedation provider course. Teach Learn Med. 2013;25(3):249-57. PMID: 23848333.

Hutchinson EB, Sobakin AS, Meyerand ME, Eldridge M, Ferrazzano P. Diffusion tensor MRI of spinal decompression sickness. Undersea Hyperb Med. 2013 Jan-Feb;40(1):23-31. PMID: 23397865.

Limberg JK, Harrell JW, Johansson RE, Eldridge MW, Proctor LT, Sebranek JJ, Schrage WG. Microvascular function in younger adults with obesity and metabolic syndrome: role of oxidative stress. Am J Physiol Heart Circ Physiol. 2013 Oct 15;305(8):H1230-7. Epub 2013 Aug 9. PMID: 23934859.

Schmit TL, Dowell JA, Maes ME, Wilhelm M. c-Jun N-terminal kinase regulates mGluR-dependent expression of post-synaptic FMRP target proteins. J Neurochem. 2013 Dec;127(6):772-81. Epub 2013 Oct 24. PMID: 24047560.

Shi Y, Yuan H, Kim D, Chanana V, Baba A, Matsuda T, Cengiz P, Ferrazzano P, Sun D. Stimulation of na(+)/h(+) exchanger isoform 1 promotes microglial migration. PLoS One. 2013 Aug 21;8(8):e74201. eCollection 2013. PMID: 23991215.

Uluc K, Kendigelen P, Fidan E, Zhang L, Chanana V, Kintner D, Akture E, Song C, Ye K, Sun D, Ferrazzano P, Cengiz P. TrkB receptor agonist 7, 8 dihydroxyflavone triggers profound gender-dependent neuroprotection in mice after perinatal hypoxia and ischemia. CNS Neurol Disord Drug Targets. 2013 May 1;12(3):360-70. PMID: 23469848.

Grant Support

Our faculty were principal investigators on the following grants during calendar year 2013.

Principal Investigator Funding Agency Title
Boriosi, Juan Hoffmann-Laroche, Inc. Roche Tamiflu Protocol NP25139C
Boriosi, Juan Hoffmann-Laroche, Inc. Roche Tamiflu Protocol NP25138
Boriosi, Juan University of California–San Francisco Targeted Genomic Analysis of Coagulation Pathways in Acute Lung Injury
Boriosi, Juan Isomark Changes In 13C/12C Delta Value in Breath as a Biomarker of Systemic Inflammatory Response Syndrome in Mechanically Ventilated Pediatric and Adult Patients
Boriosi, Juan Purdue Pharma BUP 3030
Cengiz, Pelin DHHS, PHS, National Institutes of Health The Role of Na+/H+ Exchanger Isoform 1 in Neonatal Hypoxia and Ischemia
Eldridge, Marlowe DOD, Navy Aleksey Sobakin, Salary Support
Eldridge, Marlowe DOD, Navy Development of Decompression and Oxygen Pre-Breathe Schedules for Submarine Escape and Rescue using UW Sheep Model
Eldridge, Marlowe DHHS, PHS, National Institutes of Health Comprehensive Characterization of Intrapulmonary Arteriovenous Pathways in Health
Eldridge, Marlowe DHHS, PHS, National Institutes of Health Right Heart-Pulmonary Vascular Interactions in Bronchopulmonary Dysplasia
Ferrazzano, Peter DHHS, PHS, National Institutes of Health MRI Biomarkers of Pediatric Brain Injury
Ferrazzano, Peter DHHS, PHS, National Institutes of Health Age-Dependent Microglial Responses in Hypoxia-Ischemia
Wilhelm, Michael DHHS, PHS, National Institutes of Health Regulation of Dendritic APP Translation
Wilhelm, Michael Fraxa Research Foundation The Role of JNK in FMRP-Regulated Translation in Fragile X Syndrome

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