Division Highlights - Cardiology

The Division of Pediatric Cardiology and the Pediatric Heart Program of the American Family Children’s Hospital provides outstanding comprehensive care to children with congenital or acquired heart disease throughout Wisconsin and the region.

Clinical specialties include pediatric and adult congenital heart disease diagnosis and management, including care of fetuses and newborns with complex structural heart problems; noninvasive cardiac imaging; interventional catheterization; inherited arrhythmias and interventional electrophysiology; exercise physiology; and preventive cardiology.

National Institutes of Health-funded research investigates the biology of inherited cardiomyopathies and the response of the immature heart to physiologic stress, and the use of newborn screening to identify congenital heart defects.

2013 Highlights

  • J. Carter Ralphe, MD, received a $50,000 award from the Children’s Cardiomyopathy Foundation for his project, “Human IPS Cells and ECT in the Study of Hypertrophic Cardiomyopathy.”
  • With the recruitment of Luke Lamers, MD, in summer 2012, the division expanded its cardiac catheterization capabilities, providing approximately 150 services that previously were referred elsewhere.
  • The American Family Children's Hospital pediatric preventive cardiology clinic, led by Amy Peterson, MD, Ann Dodge, NP, and Erin Marriott, NP, saw 193 patients in 2013, a nearly 250% increase from the 78 seen in 2012. The clinic was launched in 2011 to help children reduce or eliminate risk factors for adult cardiovascular disease.


J. Carter Ralphe, MD

Assistant Professor and
Division Chief

John S. Hokanson, MD

Associate Professor (CHS)

Luke J. Lamers, MD

Assistant Professor (CHS)

Ian H. Law, MD

Clinical Associate Professor

Kathleen R. Maginot, MD

Associate Professor (CHS)

Amy L. H. Peterson, MD

Assistant Professor (CHS)

Shardha Srinivasan, MD

Associate Professor (CHS)

Nicholas H. Von Bergen, MD

Clinical Assistant Professor

Larry H. Weinhaus, MD

Clinical Instructor

Allen D. Wilson, MD

Professor (CHS)


Recent Publications

De Lange WJ, Grimes AC, Hegge LF, Ralphe JC. Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue. J Gen Physiol. 2013 Jan;141(1):73-84. PMID: 23277475.

De Lange WJ, Grimes AC, Hegge LF, Spring AM, Brost TM, Ralphe JC. E258K HCM-causing mutation in cardiac MyBP-C reduces contractile force and accelerates twitch kinetics by disrupting the cMyBP-C and myosin S2 interaction. J Gen Physiol. 2013 Sep;142(3):241-55. PMID:23980194.

Egan KR, Ralphe JC, Weinhaus L, Maginot KR. Just sinus bradycardia or something more serious? Case Rep Pediatr. 2013;2013:736164. Epub 2013 Feb 11. PMID: 23476865.

Egan KR, Srinivasan S, Hagen SA, Anagnostopoulos PV. Late manifestation of coarctation of the aorta after arterial switch operation for D-transposition of the great arteries with intact ventricular septum. Pediatr Cardiol. 2013 Mar;34(3):729-32. PMID: 22562776.

Kamp AN, Von Bergen NH, Henrikson CA, Makhoul M, Saarel EV, Lapage MJ, Russell MW, Strieper M, Yu S, Dick M, Day SM, Bradley DJ. Implanted defibrillators in young hypertrophic cardiomyopathy patients: a multicenter study. Pediatr Cardiol. 2013 Oct;34(7):1620-7. Epub 2013 Mar 20. PMID: 23512332.

Malloy L, Law IH, Von Bergen NH. Voltage mapping for slow-pathway visualization and ablation of atrioventricular nodal reentry tachycardia in pediatric and young adult patients. Pediatr Cardiol. 2014 Jan;35(1):103-7. Epub 2013 Jul 20. PMID: 23872907.

Peterson AL, Srinivasan S, Hokanson JS. Evaluating newborns for critical congenital heart disease: expanding the availability of diagnostic echocardiography, Congenital Cardiology Today 2013 Nov;11 (11):1-7.

Ralphe JC, de Lange WJ. 3D engineered cardiac tissue models of human heart disease: learning more from our mice. Trends Cardiovasc Med. 2013 Feb;23(2):27-32. Epub 2013 Jan 5. Review. PMID: 23295081.

Grant Support

Our faculty were principal investigators on the following grants during calendar year 2013.

Principal Investigator Funding Agency Title
Hokanson, John DHSS, PHS, Health Resources and Services SHINE - Wisconsin Congenital Heart Disease Newborn Screening Program
Hokanson, John Multiple Donors Congenital Heart Disease Screening
Ralphe, J. Carter American Heart Association Greater Midwest Affiliate POSH and Familial Hypertrophic Cardiomyopathy: Bridging the Gap Between Genetic Mutation and Hypertrophy
Ralphe, J. Carter DHSS, PHS, Health Resources and Services Murine 3D Engineered Tissue Model of Human MYBPC3 Mutations
Ralphe, J. Carter Children's Cardiomyopathy Foundation Harnessing the Power of Human iPS cells and Engineered Cardiac Tissue to Study Familial Hypertrophic Cardiomyopathy

View Other Divisions' Highlights