The Division of Allergy, Immunology, and Rheumatology provides state-of-the-art, evidence-based care for children with asthma, allergies, immunologic disorders, and rheumatologic diseases.
Our basic and clinical research projects are designed to better understand and find more effective treatments for these diseases.
- James Gern, MD, was inducted in the Alpha Omega Alpha Honor Medical Society, and to the Board of Directors of the American Academy of Allergy, Asthma and Immunology.
- James Gern, MD, Christine Seroogy, MD, along with Yury Bochkov, PhD, Ann Palmenberg, PhD (Institute of Molecular Virology), John Yin, PhD (Biochemical Engineering) and Matt Keifer, MD (Marshfield Clinic) received a National Institutes of Health–National Institute of Allergy and Infectious Diseases (NIH-NIAID) U19 Program Project grant to investigate whether farm-related microbes promote immune development, thereby limiting the severity of viral respiratory illnesses in early childhood.
- Anna Huttenlocher, MD, was elected to the American Society for Clinical Investigation Council, and also received a University of Wisconsin Vilas Distinguished Research Professorship. In addition, Emily Gasteyer, an undergraduate student she mentored, received a 2013-2014 Wisconsin Hilldale Undergraduate/Faculty Research Fellowship for her project, “The Role of Lymphoid Tyrosine Phosphatase in Neutrophil Signaling and Chemotaxis.”
- Daniel Jackson, MD, received a €30,000 international Klosterfrau Award for Research of Airway Diseases in Childhood for his project, “Evidence for a Causal Relationship between Allergic Sensitization and Rhinovirus Wheezing in Early Life.”
- Robert Lemanske, MD, received a $1.5 million per year program project research grant from the National, Heart, Lung, and Blood Institute to continue evaluating genetic and environmental factors that contribute to the initiation, progression, and remission of childhood asthma. He was also elected to be the future president (2015) of the American Academy of Allergy, Asthma, and Immunology.
- Kate Swenson, NP, Theresa Guilbert, MD, MS, and Kathleen Shanovich, NP, received a $7,000 grant from the Evjue Foundation to support the Pediatric Asthma Clinic at Access Community Health Centers.
- Judith Smith, MD, PhD, received a two-year, $400,000 award from the Rheumatology Research Foundation for her project, “Analysis of causal variants in the IL-23/IL-17 pathway in axial spondyloarthritis.” She also received a $125,000 award from the NIH-NIAID Great Lakes Regional Center of Excellence and a $15,000 University of Wisconsin Graduate School Fall Competition Award supplement for her project, “The Role of the Unfolded Protein Response in Brucella Replication.” Dr. Smith was awarded the Department of Pediatrics Gerard Odell prize for Research in 2013.
Professor and Division Chief
Clinical Associate Professor
Assistant Professor (CHS)
Adura PT, Reed E, Macintyre J, Del Rosario A, Roberts J, Pestridge R, Beegan R, Boxall CB, Xiao C, Kebadze T, Aniscenko J, Cornelius V, Gern JE, Monk PD, Johnston SL, Djukanovic R. Experimental rhinovirus 16 infection in moderate asthmatics on inhaled corticosteroids. Eur Respir J. 2013 Dec 5. [Epub ahead of print] PMID: 24311773.
Basta HA, Ashraf S, Sgro JY, Bochkov YA, Gern JE, Palmenberg AC. Modeling of the human rhinovirus C capsid suggests possible causes for antiviral drug resistance. Virology. Epub 2013 Oct 20. PMID: 24314639.
Becker TM, Durrani SR, Bochkov YA, Devries MK, Rajamanickam V, Jackson DJ. Effect of exogenous interferons on rhinovirus replication and airway inflammatory responses. Ann Allergy Asthma Immunol. 2013 Nov;111(5):397-401. Epub 2013 Aug 28. PMID: 24125148.
Beigelman A, King TS, Mauger D, Zeiger RS, Strunk RC, Kelly HW, Martinez FD, Lemanske RF Jr, Rivera-Spoljaric K, Jackson DJ, Guilbert T, Covar R, Bacharier LB; Childhood Asthma Research and Education Network of National Heart, Lung, and Blood Institute. Do oral corticosteroids reduce the severity of acute lower respiratory tract illnesses in preschool children with recurrent wheezing? J Allergy Clin Immunol. 2013 Jun;131(6):1518-25. Epub 2013 Mar 14. PMID: 23498594.
Berthier E, Guckenberger DJ, Cavnar P, Huttenlocher A, Keller NP, Beebe DJ. Kit-on-a-lid-assays for accessible self-contained cell assays. Lab Chip. 2013 Feb 7;13(3):424-31. PMID: 23229806.
Berthier E, Lim FY, Deng Q, Guo CJ, Kontoyiannis DP, Wang CC, Rindy J, Beebe DJ, Huttenlocher A, Keller NP. Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites. PLoS Pathog. 2013;9(4):e1003289. Epub 2013 Apr 11. PMID: 23592999.
Bischel LL, Mader BR, Green JM, Huttenlocher A, Beebe DJ. Zebrafish entrapment by restriction array (ZEBRA) device: a low-cost, agarose-free zebrafish mounting technique for automated imaging. Lab Chip. 2013 May 7;13(9):1732-6. PMID: 23503983.
Bochkov YA, Busse WW, Brockman-Schneider RA, Evans MD, Jarjour NN, McCrae C, Miller-Larsson A, Gern JE. Budesonide and formoterol effects on rhinovirus replication and epithelial cell cytokine responses. Respir Res. 2013 Oct 4;14:98. PMID: 24219422.
Calışkan M, Bochkov YA, Kreiner-Møller E, Bønnelykke K, Stein MM, Du G, Bisgaard H, Jackson DJ, Gern JE, Lemanske RF Jr, Nicolae DL, Ober C. Rhinovirus wheezing illness and genetic risk of childhood-onset asthma. N Engl J Med. 2013 Apr 11;368(15):1398-407. Epub 2013 Mar 27. PMID: 23534543.
Chang TS, Lemanske RF Jr, Guilbert TW, Gern JE, Coen MH, Evans MD, Gangnon RE, Page CD, Jackson DJ. Evaluation of the modified asthma predictive index in high-risk preschool children. J Allergy Clin Immunol Pract. 2013 Mar 1;1(2). PMID: 24187656.
Chang TS, Lemanske RF Jr, Mauger DT, Fitzpatrick AM, Sorkness CA, Szefler SJ, Gangnon RE, Page CD, Jackson DJ; on behalf of the Childhood Asthma Research and Education (CARE) Network Investigators. Childhood asthma clusters and response to therapy in clinical trials. J Allergy Clin Immunol. 2013 Oct 15. [Epub ahead of print] PMID: 24139497.
Cox DW, Bizzintino J, Ferrari G, Khoo SK, Zhang G, Whelan S, Lee WM, Bochkov YA, Geelhoed GC, Goldblatt J, Gern JE, Laing IA, Le Souëf PN. Human rhinovirus species C infection in young children with acute wheeze is associated with increased acute respiratory hospital admissions. Am J Respir Crit Care Med. 2013 Dec 1;188(11):1358-64. PMID: 23992536.
Dagliyan O, Shirvanyants D, Karginov AV, Ding F, Fee L, Chandrasekaran SN, Freisinger CM, Smolen GA, Huttenlocher A, Hahn KM, Dokholyan NV. Rational design of a ligand-controlled protein conformational switch. Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6800-4. Epub 2013 Apr 8. PMID: 23569285.
Deng Q, Sarris M, Bennin DA, Green JM, Herbomel P, Huttenlocher A. Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish. J Leukoc Biol. 2013 May;93(5):761-9. Epub 2013 Mar 8. PMID: 23475575.
Esbenshade JC, Edwards KM, Esbenshade AJ, Rodriguez VE, Talbot HK, Joseph MF, Nwosu SK, Chappell JD, Gern JE, Williams JV, Talbot TR. Respiratory virus shedding in a cohort of on-duty healthcare workers undergoing prospective surveillance. Infect Control Hosp Epidemiol. 2013 Apr;34(4):373-8. Epub 2013 Feb 8. PMID: 23466910.
Fert I, Cagnard N, Glatigny S, Letourneur F, Jacques S, Smith JA, Colbert RA, Taurog JD, Chiocchia G, Araujo LM, Breban M. Reverse interferon signature is characteristic of antigen-presenting cells in human and rat spondyloarthritis. Arthritis Rheum. 2013 Dec 24. [Epub ahead of print] PMID: 24374654.
Gavala ML, Bashir H, Gern JE. Virus/allergen interactions in asthma. Curr Allergy Asthma Rep. 2013 Jun;13(3):298-307. PMID: 23475539.
Gavala ML, Liu YP, Lenertz LY, Zeng L, Blanchette JB, Guadarrama AG, Denlinger LC, Bertics PJ, Smith JA. Nucleotide receptor P2RX7 stimulation enhances LPS-induced interferon-β production in murine macrophages. J Leukoc Biol. 2013 Oct;94(4):759-68. Epub 2013 Aug 2. PMID: 23911869.
Gern JE, Palmenberg AC. Rhinoviruses. In: Knipe D, Howley P, eds. Field’s Virology. Philadelphia:Williams & Wilkins. 2013.
Giampietro PF, Baker MW, Basehore MJ, Jones JR, Seroogy CM. Novel mutation in TP63 associated with ectrodactyly ectodermal dysplasia and clefting syndrome and T cell lymphopenia. Am J Med Genet A. 2013 Jun;161A(6):1432-5. Epub 2013 Apr 23. PMID: 23613309.
Himes BE, Sheppard K, Berndt A, Leme AS, Myers RA, Gignoux CR, Levin AM, Gauderman WJ, Yang JJ, Mathias RA, Romieu I, Torgerson DG, Roth LA, Huntsman S, Eng C, Klanderman B, Ziniti J, Senter-Sylvia J, Szefler SJ, Lemanske RF Jr, Zeiger RS, Strunk RC, Martinez FD, Boushey H, Chinchilli VM, Israel E, Mauger D, Koppelman GH, Postma DS, Nieuwenhuis MA, Vonk JM, Lima JJ, Irvin CG, Peters SP, Kubo M, Tamari M, Nakamura Y, Litonjua AA, Tantisira KG, Raby BA, Bleecker ER, Meyers DA, London SJ, Barnes KC, Gilliland FD, Williams LK, Burchard EG, Nicolae DL, Ober C, DeMeo DL, Silverman EK, Paigen B, Churchill G, Shapiro SD, Weiss ST. Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS One. 2013;8(2):e56179. PMID: 23457522.
Himes BE, Qiu W, Klanderman B, Ziniti J, Senter-Sylvia J, Szefler SJ, Lemanske RF Jr, Zeiger RS, Strunk RC, Martinez FD, Boushey H, Chinchilli VM, Israel E, Mauger D, Koppelman GH, Nieuwenhuis MA, Postma DS, Vonk JM, Rafaels N, Hansel NN, Barnes K, Raby B, Tantisira KG, Weiss ST. ITGB5 and AGFG1 variants are associated with severity of airway responsiveness. BMC Med Genet. 2013 Aug 28;14:86. PMID: 23984888.
Huttenlocher A. ECM: chemoattraction but not adhesion. Blood. 2013 Feb 28;121(9):1489-91. PMID: 23449615.
Lam PY, Harvie EA, Huttenlocher A. Heat shock modulates neutrophil motility in zebrafish. PLoS One. 2013 Dec 19;8(12):e84436. eCollection 2013. PMID: 24367659.
Lam PY, Huttenlocher A. Interstitial leukocyte migration in vivo. Curr Opin Cell Biol. 2013 Oct;25(5):650-8. Epub 2013 Jun 21. Review. PMID: 23797028.
Langereis JD, Koenderman L, Huttenlocher A, Ulfman LH. Gelsolin expression increases β1 -integrin affinity and L1210 cell adhesion. Cytoskeleton (Hoboken). 2013 Jul;70(7):385-93. Epub 2013 May 10. PMID: 23595955.
Lemanske RF Jr. Early-life wheezing and respiratory syncytial virus prevention. N Engl J Med. 2013 May 9;368(19):1839-41. PMID: 23656652.
Lemanske RF Jr. In person with: Robert F. Lemanske, Jr., MD, FAAAAI. J Allergy Clin Immunol. 2013 May;131(5):34A-35A. PMID: 23757771.
Li X, Hawkins GA, Ampleford EJ, Moore WC, Li H, Hastie AT, Howard TD, Boushey HA, Busse WW, Calhoun WJ, Castro M, Erzurum SC, Israel E, Lemanske RF Jr, Szefler SJ, Wasserman SI, Wenzel SE, Peters SP, Meyers DA, Bleecker ER. Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients. J Allergy Clin Immunol. 2013 Aug;132(2):313-20.e15. Epub 2013 Mar 28. PMID: 23541324.
Mathis L, Wernimont S, Affentranger S, Huttenlocher A, Niggli V. Determinants of phosphatidylinositol-4-phosphate 5-kinase type Iγ90 uropod location in T-lymphocytes and its role in uropod formation. PeerJ. 2013 Aug 29;1:e131. eCollection 2013. PMID: 24010013.
Mathur SK, Fichtinger PS, Kelly JT, Lee WM, Gern JE, Jarjour NN. Interaction between allergy and innate immunity: model for eosinophil regulation of epithelial cell interferon expression. Ann Allergy Asthma Immunol. 2013 Jul;111(1):25-31. PMID: 23806456.
Mladinich KM, Huttenlocher A. WRAMPing up calcium in migrating cells by localized ER transport. Dev Cell. 2013 Sep 30;26(6):560-1. PMID: 24091010.
Obasi CN, Barrett B, Brown R, Vrtis R, Barlow S, Muller D, Gern J. Detection of viral and bacterial pathogens in acute respiratory infections. J Infect. 2014 Feb;68(2):125-30. Epub 2013 Nov 7. PMID: 24211414.
Okupa AY, Sorkness CA, Mauger DT, Jackson DJ, Lemanske RF Jr. Daily diaries vs retrospective questionnaires to assess asthma control and therapeutic responses in asthma clinical trials: is participant burden worth the effort? Chest. 2013 Apr;143(4):993-9. PMID: 23287844.
Peters SP, Bleecker ER, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Craig T, Denlinger LC, Engle LL, Dimango EA, Israel E, Kraft M, Lazarus SC, Lemanske RF Jr, Lugogo N, Martin RJ, Meyers DA, Ramsdell J, Sorkness CA, Sutherland ER, Wasserman SI, Walter MJ, Wechsler ME, Chinchilli VM, Szefler SJ; National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. Predictors of response to tiotropium versus salmeterol in asthmatic adults. J Allergy Clin Immunol. 2013 Nov;132(5):1068-1074.e1. Epub 2013 Sep 29. PMID: 24084072.
Rabinovitch N, Mauger DT, Reisdorph N, Covar R, Malka J, Lemanske RF Jr, Morgan WJ, Guilbert TW, Zeiger RS, Bacharier LB, Szefler SJ. Predictors of asthma control and lung function responsiveness to step 3 therapy in children with uncontrolled asthma. J Allergy Clin Immunol. 2013 Sep 28. pii: S0091-6749(13)01212-8. [Epub ahead of print] PMID: 24084071.
Seroogy CM. DiGeorge syndrome: Clinical features and diagnosis. UpToDate Web site. http://goo.gl/JBzVws. Updated January 11, 2013. Accessed February 19, 2014.
Seroogy CM. DiGeorge syndrome: Epidemiology and pathogenesis. UpToDate Web site. http://goo.gl/EvVhfZ. Updated January 11, 2013. Accessed February 19, 2014.
Seroogy CM. DiGeorge syndrome: Management and prognosis. UpToDate Web site. http://goo.gl/bB1zxE. Updated January 11, 2013. Accessed February 19, 2014.
Shelef MA, Tauzin S, Huttenlocher A. Neutrophil migration: moving from zebrafish models to human autoimmunity. Immunol Rev. 2013 Nov;256(1):269-81. PMID: 24117827.
Singh AM, Dahlberg P, Burmeister K, Evans MD, Gangnon R, Roberg KA, Tisler C, Dasilva D, Pappas T, Salazar L, Lemanske RF Jr, Gern JE, Seroogy CM. Inhaled corticosteroid use is associated with increased circulating T regulatory cells in children with asthma. Clin Mol Allergy. 2013 Jan 25;11(1):1. PMID: 23347774.
Smith JA, Khan M, Magnani DD, Harms JS, Durward M, Radhakrishnan GK, Liu YP, Splitter GA. Brucella induces an unfolded protein response via TcpB that supports intracellular replication in macrophages. PLoS Pathog. 2013 Dec;9(12):e1003785. Epub 2013 Dec 5. PMID: 24339776.
Sorkness RL, Szakaly RJ, Rosenthal LA, Sullivan R, Gern JE, Lemanske RF Jr, Sun X. Viral bronchiolitis in young rats causes small airway lesions that correlate with reduced lung function. Am J Respir Cell Mol Biol. 2013 Nov;49(5):808-13. PMID: 23763491.
Stoltz DJ, Jackson DJ, Evans MD, Gangnon RE, Tisler CJ, Gern JE, Lemanske RF Jr. Specific patterns of allergic sensitization in early childhood and asthma & rhinitis risk. Clin Exp Allergy. 2013 Feb;43(2):233-41. PMID: 23331564.
Szefler SJ, Chmiel JF, Fitzpatrick AM, Giacoia G, Green TP, Jackson DJ, Nielsen HC, Phipatanakul W, Raissy HH. Asthma across the ages: Knowledge gaps in childhood asthma. J Allergy Clin Immunol. 2014 Jan;133(1):3-13. Epub 2013 Nov 28. PMID: 24290281.
Thomas AO, Lemanske RF Jr, Jackson DJ. Infections and their role in childhood asthma inception. Pediatr Allergy Immunol. 2013 Nov 17. [Epub ahead of print] PMID: 24236893.
Thompson EE, Myers RA, Du G, Aydelotte TM, Tisler CJ, Stern DA, Evans MD, Graves PE, Jackson DJ, Martinez FD, Gern JE, Wright AL, Lemanske RF, Ober C. Maternal microchimerism protects against the development of asthma. J Allergy Clin Immunol. 2013 Jul;132(1):39-44. Epub 2013 Feb 21. PMID: 23434286.
Viswanathan RK, Moss MH, Mathur SK. Retrospective analysis of the efficacy of omalizumab in chronic refractory urticaria. Allergy Asthma Proc. 2013 Sep-Oct;34(5):446-52. PMID: 23998242.
Wiemer AJ, Wernimont SA, Cung TD, Bennin DA, Beggs HE, Huttenlocher A. The focal adhesion kinase inhibitor PF-562,271 impairs primary CD4+ T cell activation. Biochem Pharmacol. 2013 Sep 15;86(6):770-81. Epub 2013 Aug 5. PMID: 23928188 .
Our faculty were principal investigators on the following grants during calendar year 2013.
|Principal Investigator||Funding Agency||Title|
|Gern, James||Wisconsin Alumni Research Foundation||The Cholesterol-Lowering Drug, Simvastatin, Attenuates Rhinovirus-Induced IP-10 Release from Human Monocytic Cells|
|Gern, James||DHHS, PHS, National Institutes of Health||Wisconsin Allergy Research Training (WISCART) Program|
|Gern, James||DHHS, PHS, National Institutes of Health||Mechanisms and Environmental Determinants of Rhinovirus Illness Severity|
|Huttenlocher, Anna||DHHS, PHS, National Institutes of Health||Regulation of Mast Cell Function by Inhibitory Molecules|
|Huttenlocher, Anna||DHHS, PHS, National Institutes of Health||Adhesive Regulation During Cell Migration|
|Huttenlocher, Anna||DHHS, PHS, National Institutes of Health||Integrated Training for Physician-Scientists|
|Huttenlocher, Anna||Duke University||CARRAnet Registry|
|Huttenlocher, Anna||DHHS, PHS, National Institutes of Health||Cytoskeletal Regulation of T-cell–APC Interactions|
|Huttenlocher, Anna||DHHS, PHS, National Institutes of Health||Reactive Oxygen Species in the Resolution of Inflammation|
|Huttenlocher, Anna||DHHS, PHS, National Institutes of Health||A Toolkit for Imaging and Photo-manipulation of Signaling in Zebrafish|
|Huttenlocher, Anna||DHHS, PHS, National Institutes of Health||Neutrophil Chemotaxis in Autoinflammation|
|Huttenlocher, Anna||American Heart Association Greater Midwest Affiliate||Src Family Kinase-Mediated Wound Inflammation in Live Zebrafish|
|Jackson, Daniel||DHHS, PHS, National Institutes of Health||Mechanisms Linking Immune Dysregulation (ICTR KL2)|
|Jackson, Daniel||DHHS, PHS, National Institutes of Health||Epithelial Cell Allergy-Virus Interactions in Asthma|
|Jackson, Daniel||Multiple Donors||Asthma Research|
|Lemanske, Robert||DHHS, PHS, National Institutes of Health||Treatment of Severe Persistent Asthma|
|Lemanske, Robert||DHHS, PHS, National Institutes of Health||Investigating Effects of Viral Infection of Lung Development|
|Lemanske, Robert||Pennsylvania State University||AsthmaNet; April-Ocelot Viral Determinations and Bacterial Detection|
|Lemanske, Robert||Pennsylvania State University||AsthmaNet|
|Lemanske, Robert||DHHS, PHS, National Institutes of Health||Clustering to Identify Novel Phenotypes in Childhood Asthma (Chang F30)|
|Lemanske, Robert||DHHS, PHS, National Institutes of Health||COAST III and COAST IV|
|Seroogy, Christine||Midwest Athletes Against Childhood Cancer||The Gene Related to Anergy in Lymphocytes, Grail, and its Implications in CD4 T Cell Tumor Anergy|
|Seroogy, Christine||University of Minnesota||EPilot Project Exploratory Immunologic Differences in Cord Blood from Infants Born into Farming Environments Compared to Nonfarming Environments in MESA|
|Smith, Judith||DHHS, PHS, National Institutes of Health||Pathogenic Studies in Families with Twins or Siblings Discordant for Systemic Rheumatic Disorders|
|Smith, Judith||American College of Rheumatology||Excess IL-23 Production in Ankylosing Spondylitis And Related Arthritides|
|Smith, Judith||University of Chicago||The Role of the Host Unfolded Protein Response in Brucella Replication|
|Smith, Judith||Rheumatology Research Foundation||Analysis of Causal Variants in the IL-23/IL-17 Pathway in Axial Spondyloarthritis|
|Smith, Judith||Wisconsin Alumni Research Foundation||The Role of the Unfolded Protein Response in Brucella Replication|
|Syverson, Grant||Arthritis Foundation||Development of a CME Online Education Program|