Division Highlights - Infectious Diseases

The Division of Infectious Disease cares for children with common, complex, or potentially life-threatening infectious diseases and illnesses.

Research interests include international health, immunization efficacy, vaccine preventable disease epidemiology and policy, respiratory tract infections, urinary tract infections, and fungal infections.

2012 Highlights

  • The division received ACGME approval for a new fellowship training program in pediatric infectious disease. The first fellow will begin in July 2013.
  • James Conway, MD, received the UW Health Physician Excellence Award for Clinical Education. He was also selected as the guest commencement speaker by the UW School of Medicine and Public Health’s class of 2012.
  • Bruce Klein, MD, received two new grants from the National Institutes of Health: a 5-year, $2.8 million R01 grant for his project, “Mechanisms of Anti-Fungal Vaccine Immunity”, and a 2-year, $415,000 R21 grant for his project “Tracking Anti-Fungal CD4+ T cells In Vivo.”
  • Bruce Klein, MD, served as vice chair and chair-elect of the Immunology of Fungal Infections Gordon Research Conference.
  • Ellen Wald, MD, received a 2-year, $415,000 R21 grant from the National Institutes of Health-Eunice Kennedy Shriver National Institute of Child Health and Human Development (NIH-NICHD) for her project, “An Interactive Web-Based Intervention to Achieve Healthy Weight in Young Children.”
  • Ellen Wald, MD, is the principal investigator on an American Family Children’s Hospital Youth Health Transition Grant. Last year, that grant supported the "Successful Youth Transition into Adult Healthcare Summit”, which welcomed visiting professor and keynote speaker Albert Hergenroeder, MD.


Bruce S. Klein, MD

Professor and Division Chief

James H. Conway, MD

Associate Professor

Gregory P. DeMuri, MD

Associate Professor (CHS)

Sheryl L. Henderson, MD, PhD

Assistant Professor (CHS)

Ellen R. Wald, MD



Recent Publications

Chow AW, Benninger MS, Brook I, Brozek JL, Goldstein EJ, Hicks LA, Pankey GA, Seleznick M, Volturo G, Wald ER, File TM Jr, Infectious Diseases Society of America. IDSA clinical practice guideline for acute bacterial rhinosinusitis in children and adults. Clin Infect Dis. 2012 Apr;54(8):e72-e112. PMID: 22438350.

Conway JH. Vaccines – Evolution of Immunizations, Latest Developments, Cocoon Campaigns, New Recommendations, Vaccination Opposition Movement.” Audio-Digest: Emergency Medicine. 2012;29(16). 

Conway JH. Clinical prediction rule accurately identifies those at low risk for Lyme meningitis [commentary].  J Pediatrics 2012;161(1):171-2. PMID: 22726332.

DeMuri GP, Wald ER. Clinical practice. Acute bacterial sinusitis in children. N Engl J Med. 2012 Sep 20;367(12):1128-34. PMID: 22992076.

Ivy W 3rd, Dominguez KL, Rakhmanina NY, Iuliano AD, Danner SP, Borkowf CB, Denson AP, Gaur AH, Mitchell CD, Henderson SL, Paul ME, Barton T, Herbert-Grant M, Hader SL, Pérez García E, Malachowski JL, Nesheim SR. Premastication as a route of pediatric HIV transmission: case-control and cross-sectional investigations. J Acquir Immune Defic Syndr. 2012 Feb 1;59(2):207-12. PMID: 22027873.

Kawai K, OʼBrien MA, Conway JH, Marshall GS, Kuter BJ. Factors associated with receipt of two doses of varicella vaccine among adolescents in the United States. Pediatr Infect Dis J. 2012 Nov 28. PMID: 23190788.

Li W, Sullivan TD, Walton E, Averette AF, Sakthikumar S, Cuomo CA, Klein BS, Heitman J. Identification of the mating-type (MAT) locus that controls sexual reproduction of Blastomyces dermatitidis. Eukaryot Cell. 2013 Jan;12(1):109-17. Epub 2012 Nov 9. PMID: 23143684.

Nanjappa SG, Heninger E, Wüthrich M, Gasper DJ, Klein BS. Tc17 cells mediate vaccine immunity against lethal fungal pneumonia in immune deficient hosts lacking CD4+ T cells. PLoS Pathog. 2012;8(7):e1002771. PMID: 22829762.

Roy RM, Klein BS. Dendritic cells in antifungal immunity and vaccine design. Dendritic cells in antifungal immunity and vaccine design.. Cell Host and Microbe.  2012. May 17;11(5):436-46. PMID: 22607797.

Roy RM, Wüthrich M, Klein BS. Chitin elicits CCL2 from airway epithelial cells and induces CCR2-dependent innate allergic inflammation in the lung. J Immunol. 2012 Sep 1;189(5):2545-52. PMID: 22851704.

Shaikh N, Wald ER, Pi M. Decongestants, antihistamines and nasal irrigation for acute sinusitis in children. Cochrane Database Syst Rev. 2012 Sep 12;9:CD007909. PMID: 22972113.

Tebbets B, Stewart D, Lawry S, Nett J, Nantel A, Andes D, Klein BS. Identification and characterization of antifungal compounds using a Saccharomyces cerevisiae reporter bioassay. PLoS One. 2012;7(5):e36021. PMID: 22574132.

Tebbets B, Yu Z, Stewart D, Zhao LX, Jiang Y, Xu LH, Andes D, Shen B, Klein B. Identification of antifungal natural products via Saccharomyces cerevisiae bioassay: insights into macrotetrolide drug spectrum, potency and mode of action. Med Mycol. 2012 Aug 28. [Epub ahead of print]. PMID: 22928922.

Wald ER. Staphylococcus aureus: is it a pathogen of acute bacterial sinusitis in children and adults? Clin Infect Dis. 2012 Mar;54(6):826-31. PMID: 22198792.

Wald ER, Conway JH. Mastoiditis. In: Long SS, Pickering LK, Prober CG, eds. Principles and Practice of Pediatric Infectious Disease. 4th ed. St. Louis: Elsevier Saunders. 2012;222-227.

Wüthrich M, Ersland K, Pick-Jacobs JC, Gern BH, Frye CA, Sullivan TD, Brennan MB, Filutowicz HI, O'Brien K, Korthauer KD, Schultz-Cherry S, Klein BS. Limited model antigen expression by transgenic fungi induces disparate fates during differentiation of adoptively transferred T cell receptor transgenic CD4+ T cells: robust activation and proliferation with weak effector function during recall. Infect Immun. 2012 Feb;80(2):787-97. PMID: 22124658.

Wüthrich M, Ersland K, Sullivan T, Galles K, Klein BS. Fungi subvert vaccine T cell priming at the respiratory mucosa by preventing chemokine-induced influx of inflammatory monocytes. Immunity. 2012 Apr 20;36(4):680-92. PMID: 22483803.

Grant Support

Our faculty were principal investigators on the following grants during calendar year 2012.

Principal Investigator Funding Agency Title
Conway, James Sanofi Pasteur Surveillance for Rates of Pertussis Disease Among Persons Birth Through 59 Months of Age Receiving Pentacel or Other Pertussis Vaccines
Klein, Bruce The Hartwell Foundation J. Carmen Postdoctoral Fellowship
Klein, Bruce DHHS, PHS, National Institutes of Health American Asthma Foundation Environmental Chitin Exposure in the Pathogenesis of Asthma (Rene Roy Pre-doctoral Fellowship)
Klein, Bruce DHHS, PHS, National Institutes of Health ARRA Targeting Hybrid Histidine Kinase for Broad-Spectrum Antifungal Therapy
Klein, Bruce DHHS, PHS, National Institutes of Health Mechanisms of Anti-Fungal Vaccine Immunity
Klein, Bruce DHHS, PHS, National Institutes of Health Molecular Pathogenesis of Blastomycosis
Klein, Bruce Wisconsin Alumni Research Foundation WARF Accelerator Program
Klein, Bruce DHHS, PHS, National Institutes of Health T32-Microbes in Health and Disease
Klein, Bruce UWF–Wisconsin Partnership Program (MERC) Wisconsin Center for Infectious Disease (WisCID)
Wald, Ellen Medimmune, Inc. An Observational Prospective Study to Assess the Outcomes and Risk Factors of RSV Infection Among Premature Infants (32-35 weeks Gestational Age)
Wald, Ellen Thrasher Research Fund Short (5 days) versus Long (14 days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in Children
Wald, Ellen Children's Hospital of Pittsburgh Corticosteroids for Children with Febrile Urinary Tract Infections (Shaikh R01)
Wald, Ellen Glaxosmithkline HIB-097
Wald, Ellen DHHS, PHS, National Institutes of Health Sinusitis in Children and the Nasopharyngeal Microbiome (R01)
Wald, Ellen DHHS, PHS, National Institutes of Health An Interactive Web-Based Intervention to Achieve Healthy Weight in Young Children
Wald, Ellen American Academy of Pediatrics CATCH Professorship
Wüthrich, Marcel DHHS, PHS, National Institutes of Health Regulation of Vaccine-Induced Anti-Fungal T17 Cells

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