Division Highlights - Allergy, Immunology & Rheumatology

The Division of Allergy, Immunology, and Rheumatology provides state-of-the-art, evidence-based care for children with asthma, allergies, immunologic disorders, and rheumatologic diseases.

Our basic and clinical research projects are designed to better understand and find more effective treatments for these diseases.

2012 Highlights

  • James Gern, MD, and Anna Huttenlocher, MD, were elected to the Association of American Physicians.
  • James Gern, MD, and Robert Lemanske, MD, were named “Top Doctors” by Madison Magazine.
  • Robert Lemanske, MD, was elected president-elect of the American Academy of Allergy, Asthma, and Immunology.
  • Christine Seroogy, MD, received a $20,000 award from the Upper Midwest Agricultural Safety and Health Center for her project, “Exploratory Immunologic Differences in Cord Blood from Infants Born into Farming Environments Compared to Nonfarming Environments in MESA.” She was also one of the first recipients of the UW Health Patient Experience Physician Champion Award, which recognizes physicians who have achieved exemplary communication skills in the 2011 Avatar patient satisfaction survey.
  • Christine Seroogy, MD, and department chair Ellen Wald, MD, received a CATCH visiting professorship grant from the American Academy of Pediatrics, which was used to bring Dr. Holmes Morton to the department.
  • Judith Smith, MD, PhD, received a one-year, $75,000 award from the American College of Rheumatology for project, “Excess IL-23 production in ankylosing spondylitis and related arthritides.”
  • Daniel Jackson, MD, was selected to present his research at the Presidential Plenary Session at the American Academy of Allergy, Asthma and Immunology 2012 annual meeting.


Robert F. Lemanske, Jr., MD

Professor and Division Chief

Marcus Cohen, MD

Clinical Professor

James E. Gern, MD


Christopher T. Healy, MD

Clinical Associate Professor

Anna Huttenlocher, MD


Daniel J. Jackson, MD

Assistant Professor

Mark H. Moss, MD

Associate Professor

Michael W. Ritter, MD

Associate Professor

Christine M. Seroogy, MD

Associate Professor

Judith A. Smith, MD, PhD

Assistant Professor

Grant D. Syverson, MD

Assistant Professor (CHS)

Alex Thomas, MD


Recent Publications

Annamalay AA, Khoo SK, Jacoby P, Bizzintino J, Zhang G, Chidlow G, Lee WM, Moore HC, Harnett GB, Smith DW, Gern JE, LeSouef PN, Laing IA, Lehmann D; Kalgoorlie Otitis Media Research Project Team. Prevalence of and risk factors for human rhinovirus infection in healthy aboriginal and non-aboriginal Western Australian children. Pediatr Infect Dis J. 2012 Jul;31(7):673-9. PMID: 22481423.

Ashraf S, Brockman-Schneider R, Bochkov YA, Pasic TR, Gern JE. Biological characteristics and propagation of human rhinovirus-C in differentiated sinus epithelial cells. Virology. 2012 Nov 27. PMID: 23199420.

Barrett B, Hayney MS, Muller D, Rakel D, Ward A, Obasi CN, Brown R, Zhang Z, Zgierska A, Gern J, West R, Ewers T, Barlow S, Gassman M, Coe CL. Meditation or exercise for preventing acute respiratory infection: a randomized controlled trial. Ann Fam Med. 2012 Jul-Aug;10(4):337-46. PMID: 22778122.

Bell MC, Jackson DJ. Prevention of anaphylaxis related to mast cell activation syndrome with omalizumab. Ann Allergy Asthma Immunol. 2012 May;108(5):383-4. PMID: 22541416.

Boateng LR, Cortesio CL, Huttenlocher A. Src-mediated phosphorylation of mammalian Abp1 (DBNL) regulates podosome rosette formation in transformed fibroblasts. J Cell Sci. 2012 Mar 1;125(Pt 5):1329-41. PMID: 22303001.

Boateng LR, Huttenlocher A. Spatiotemporal regulation of Src and its substrates at invadosomes. Eur J Cell Biol. 2012 Nov-Dec;91(11-12):878-88. PMID: 22823952.

Bochkov YA, Gern JE. Clinical and molecular features of human rhinovirus C. Microbes Infect. 2012 Jun;14(6):485-94. PMID: 22285901.

Busse WW, Gern JE. Asthma and pregnancy: do they give clues to abnormal antiviral activity? Thorax. 2012 Mar;67(3):189-90. PMID: 21984364.

Cadman RV, Lemanske Jr RF, Evans MD, Jackson DJ, Gern JE, Sorkness RL, Fain SB. Pulmonary (3)He magnetic resonance imaging of childhood asthma. Allergy Clin Immunol. 2012 Dec 11. PMID: 23246019.

Calhoun WJ, Ameredes BT, King TS, Icitovic N, Bleecker ER, Castro M, Cherniack RM, Chinchilli VM, Craig T, Denlinger L, DiMango EA, Engle LL, Fahy JV, Grant JA, Israel E, Jarjour N, Kazani SD, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Moore WC, Pascual R, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Boushey HA; Asthma Clinical Research Network of the National Heart, Lung, and Blood Institute. Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. JAMA. 2012 Sep 12;308(10):987-97. PMID: 22968888.

Cavnar PJ, Mogen K, Berthier E, Beebe DJ, Huttenlocher A. The actin regulatory protein HS1 interacts with Arp2/3 and mediates efficient neutrophil chemotaxis. J Biol Chem. 2012 Jul 20;287(30):25466-77. PMID: 22679023.

Deng Q, Harvie EA, Huttenlocher A. Distinct signalling mechanisms mediate neutrophil attraction to bacterial infection and tissue injury. Cell Microbiol. 2012 Apr;14(4):517-28. PMID: 22188170.

Deng Q, Huttenlocher A. Leukocyte migration from a fish eye's view. J Cell Sci. 2012 Sep 1;125(Pt 17):3949-56. PMID: 23104739.

Denlinger LC, Manthei DM, Seibold MA, Ahn K, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Chinchili VM, Fahy JV, Hawkins GA, Icitovic N, Israel E, Jarjour NN, King T, Kraft M, Lazarus SC, Lehman E, Martin RJ, Meyers DA, Peters SP, Sheerar D, Shi L, Sutherland ER, Szefler SJ, Wechsler ME, Sorkness CA, Lemanske RF Jr; the NHLBI Asthma Clinical Research Network Investigators. P2X7-regulated protection from exacerbations and loss of control Is independent of asthma maintenance therapy. Am J Respir Crit Care Med. 2013 Jan 1;187(1):28-33. Epub 2012 Nov 9. PMID: 23144325.

Durrani SR, Montville DJ, Pratt AS, Sahu S, DeVries MK, Rajamanickam V, Gangnon RE, Gill MA, Gern JE, Lemanske RF Jr, Jackson DJ. Innate immune responses to rhinovirus are reduced by the high-affinity IgE receptor in allergic asthmatic children. J Allergy Clin Immunol. 2012 Aug;130(2):489-95. PMID: 22766097.

Esnault S, Kelly E, Nettenstrom L, Cook E, Seroogy CM, Jarjour N. Human eosinophils release IL-1ß and increase expression of IL-17A in activated CD4+ T lymphocytes. Clin Exp Allergy. 2012 Dec;42(12):1756-64. PMID: 23181791.

Fuhlbrigge A, Peden D, Apter AJ, Boushey HA, Camargo CA Jr, Gern J, Heymann PW, Martinez FD, Mauger D, Teague WG, Blaisdell C. Asthma outcomes: exacerbations. J Allergy Clin Immunol. 2012 Mar;129(3 Suppl):S34-48. PMID: 22386508.

Fuhlbrigge AL, Lemanske RF Jr, Rasouliyan L, Sorkness CA, Fish JE. Practice patterns for oral corticosteroid burst therapy in the outpatient management of acute asthma exacerbations. Allergy Asthma Proc. 2012 Jan-Feb;33(1):82-9. PMID: 22183118.

Fujimura KE, Rauch M, Matsui E, Iwai S, Calatroni A, Lynn H, Mitchell H, Johnson CC, Gern JE, Togias A, Boushey HA, Kennedy S, Lynch SV. Development of a standardized approach for environmental microbiota investigations related to asthma development in children.  J Microbiol Methods. 2012 Nov;91(2):231-9. PMID: 22975469.

Gern JE, Pappas T, Visness CM, Jaffee KF, Lemanske RF, Togias A, Bloomberg GR, Cruikshank WW, Lamm C, Tuzova M, Wood RA, Lee WM. Comparison of the etiology of viral respiratory illnesses in inner-city and suburban infants. J Infect Dis. 2012 Nov;206(9):13. PMID: 23014674.

Gern JE. Interferon-λ1 and viral wheeze in asthma: a Gothic duality? Am J Respir Crit Care Med. 2012 Mar 1;185(5):468-70. PMID: 22383563.

Harvie EA, Green JM, Neely MN, Huttenlocher A. Innate immune response to Streptococcus iniae infection in zebrafish larvae. Infect Immun. 2013 Jan;81(1):110-21. Epub 2012 Oct 22. PMID: 23090960.

Himes BE, Jiang X, Hu R, Wu AC, Lasky-Su JA, Klanderman BJ, Ziniti J, Senter-Sylvia J, Lima JJ, Irvin CG, Peters SP, Meyers DA, Bleecker ER, Kubo M, Tamari M, Nakamura Y, Szefler SJ, Lemanske RF Jr, Zeiger RS, Strunk RC, Martinez FD, Hanrahan JP, Koppelman GH, Postma DS, Nieuwenhuis MA, Vonk JM, Panettieri RA Jr, Markezich A, Israel E, Carey VJ, Tantisira KG, Litonjua AA, Lu Q, Weiss ST. Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene. PLoS Genet. 2012 Jul;8(7):e1002824. PMID: 22792082.

Jackson DJ, Evans MD, Gangnon RE, Tisler CJ, Pappas TE, Lee WM, Gern JE, Lemanske RF Jr. Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life. Am J Respir Crit Care Med. 2012 Feb 1;185(3):281-5. PMID: 21960534.

Kim WK, Gern JE. Updates in the relationship between human rhinovirus and asthma. Allergy Asthma Immunol Res. 2012 May;4(3):116-21. PMID: 22548203.

Kloepfer KM, Olenec JP, Lee WM, Liu G, Vrtis RF, Roberg KA, Evans MD, Gangnon RE, Lemanske RF Jr, Gern JE. Increased H1N1 infection rate in children with asthma. Am J Respir Crit Care Med. 2012 Jun 15;185(12):1275-9. PMID: 22366048.

Krishnan JA, Lemanske RF Jr, Canino GJ, Elward KS, Kattan M, Matsui EC, Mitchell H, Sutherland ER, Minnicozzi M. Asthma outcomes: symptoms. J Allergy Clin Immunol. 2012 Mar;129(3 Suppl):S124-35. PMID: 22386505.

Lam PY, Yoo SK, Green JM, Huttenlocher A. The SH2-domain-containing inositol 5-phosphatase (SHIP) limits the motility of neutrophils and their recruitment to wounds in zebrafish. J Cell Sci. 2012 Nov 1;125(Pt 21):4973-8. PMID: 22946052.

Lee WM, Lemanske RF Jr, Evans MD, Vang F, Pappas T, Gangnon R, Jackson DJ, Gern JE. Human rhinovirus species and season of infection determine illness severity. Am J Respir Crit Care Med. 2012 Nov 1;186(9):886-91. PMID: 22923659.

Liu YP, Zeng L, Tian A, Bomkamp A, Rivera D, Gutman D, Barber GN, Olson JK, Smith JA. Endoplasmic reticulum stress regulates the innate immunity critical transcription factor IRF3. J Immunol. 2012 Nov 1;189(9):4630-9. PMID: 23028052.

Lovell B, Moss M, Wetherell M. The psychosocial, endocrine and immune consequences of caring for a child with autism or ADHD. Psychoneuroendocrinology. 2012 Apr;37(4):534-42. PMID: 21889267.

Lovell B, Moss M, Wetherell MA. With a little help from my friends: psychological, endocrine and health corollaries of social support in parental caregivers of children with autism or ADHD. Res Dev Disabil. 2012 Mar-Apr;33(2):682-7. PMID: 22186636.

Manthei DM, Jackson DJ, Evans MD, Gangnon RE, Tisler CJ, Gern JE, Lemanske RF Jr, Denlinger LC. Protection from asthma in a high-risk birth cohort by attenuated P2X(7) function. J Allergy Clin Immunol. 2012 Aug;130(2):496-502 . PMID: 22743305.

McLoughlin RM, Calatroni A, Visness CM, Wallace PK, Cruikshank WW, Tuzova M, Ly NP, Ruiz-Perez B, Kattan M, Bloomberg GR, Lederman HM, Gern JE, Gold DR. Longitudinal relationship of early-life immunomodulatory T-cell phenotype and function to development of allergic sensitization in an urban cohort. Clin Exp Allergy. 2012;42(3):392-404. PMID: 22092655.

McMahon DF, Rajamanickam V, Salazar L, Gangnon R, Gern JE. Do asthma symptoms lag behind cold symptoms in a viral illness?  J Allergy Clin Immunol. 2012 Oct;130(4):990-1. PMID: 22728081.

Myers RA, Himes BE, Gignoux CR, Yang JJ, Gauderman WJ, Rebordosa C, Xie J, Torgerson DG, Levin AM, Baurley J, Graves PE, Mathias RA, Romieu I, Roth LA, Conti D, Avila L, Eng C, Vora H, Lenoir MA, Soto-Quiros M, Liu J, Celedón JC, Farber HJ, Kumar R, Avila PC, Meade K, Serebrisky D, Thyne S, Rodriguez-Cintron W, Rodriguez-Santana JR, Borrell LN, Lemanske RF Jr, Bleecker ER, Meyers DA, London SJ, Barnes KC, Raby BA, Martinez FD, Gilliland FD, Williams LK, Burchard EG, Weiss ST, Nicolae DL, Ober C. Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans. J Allergy Clin Immunol. 2012 Dec;130(6):1294-301. PMID: 23040885.

Nettenstrom L, Alderson K, Raschke EE, Evans MD, Sondel PM, Olek S, Seroogy CM. An optimized multi-parameter flow cytometry protocol for human T regulatory cell analysis on fresh and viably frozen cells, correlation with epigenetic analysis, and comparison of cord and adult blood. J Immunol Methods. 2013 Jan 31;387(1-2):81-8. Epub 2012 Oct 9. PMID: 23058673.

O'Brian AL, Lemanske RF Jr, Evans MD, Gangnon RE, Gern JE, Jackson DJ. Recurrent severe exacerbations in early life and reduced lung function at school age. J Allergy Clin Immunol. 2012 Apr;129(4):1162-4. PMID: 22236729.

Okupa AY, Lemanske RF Jr, Jackson DJ, Evans MD, Wood RA, Matsui EC. Early-life folate levels are associated with incident allergic sensitization. J Allergy Clin Immunol. 2013 Jan;131(1):226-228.e2. Epub 2012 Oct 4. PMID: 23040888.

Orange JS, Ballow M, Stiehm ER, Ballas ZK, Chinen J, De La Morena M, Kumararatne D, Harville TO, Hesterberg P, Koleilat M, McGhee S, Perez EE, Raasch J, Scherzer R, Schroeder H, Seroogy C, Huissoon A, Sorensen RU, Katial R. Use and interpretation of diagnostic vaccination in primary immunodeficiency: a working group report of the Basic and Clinical Immunology Interest Section of the American Academy of Allergy, Asthma & Immunology. J Allergy Clin Immunol. 2012 Sep;130(3 Suppl):S1-24. PMID: 22935624.

Papadopoulos NG, Arakawa H, Carlsen KH, Custovic A, Gern J, Lemanske R, Le Souef P, Makela M, Roberts G, Wong G, Zar H, Akdis CA, Bacharier LB, Baraldi E, van Bever HP, de Blic J, Boner A, Burks W, Casale TB, Castro-Rodriguez JA, Chen YZ, El-Gamal YM, Everard ML, Frischer T, Geller M, Gereda J, Goh DY, Guilbert TW, Hedlin G, Heymann PW, Hong SJ, Hossny EM, Huang JL, Jackson DJ, de Jongste JC, Kalayci O, Ait-Khaled N, Kling S, Kuna P, Lau S, Ledford DK, Lee SI, Liu AH, Lockey RF, Lodrup-Carlsen K, Lotvall J, Morikawa A, Nieto A, Paramesh H, Pawankar R, Pohunek P, Pongracic J, Price D, Robertson C, Rosario N, Rossenwasser LJ, Sly PD, Stein R, Stick S, Szefler S, Taussig LM, Valovirta E, Vichyanond P, Wallace D, Weinberg E, Wennergren G, Wildhaber J, Zeiger RS. International consensus on (ICON) pediatric asthma. Allergy 2012; 67(8):976-997. PMID: 22702533.

Peters B, Podlich D, Ritter M, Müller A, Wanka H, Maser-Gluth C, Seitz C, de Boni L, Maier E, Gretz N, Peters J, Hoffmann SC. A new transgenic rat model overexpressing the angiotensin II type 2 receptor provides evidence for inhibition of cell proliferation in the outer adrenal cortex. Am J Physiol Endocrinol Metab. 2012 May 15;302(9):E1044-54. PMID: 22318954.

Rosenthal LA, Szakaly RJ, Amineva SP, Xing Y, Hill MR, Palmenberg AC, Gern JE, Sorkness RL. Lower respiratory tract infection induced by a genetically modified picornavirus in its natural murine host. PLoS One. 2012;7(2):e32061. PMID: 22355409.

Sackmann EK, Berthier E, Young EW, Shelef MA, Wernimont SA, Huttenlocher A, Beebe DJ. Microfluidic kit-on-a-lid: a versatile platform for neutrophil chemotaxis assays. Blood. 2012 Oct 4;120(14):e45-53. PMID: 22915642.

Shelef MA, Bennin DA, Mosher DF, Huttenlocher A. Citrullination of fibronectin modulates synovial fibroblast behavior. Arthritis Res Ther. 2012 Nov 5;14(6):R240. PMID: 23127210.

Starnes TW, Huttenlocher A. Neutrophil reverse migration becomes transparent with zebrafish. Adv Hematol. 2012;2012:398640. PMID: 22844288.

Sumino K, Tucker J, Shahab M, Jaffee KF, Visness CM, Gern JE, Bloomberg GR, Holtzman MJ. Antiviral IFN-γ responses of monocytes at birth predict respiratory tract illness in the first year of life. J Allergy Clin Immunol. 2012 May;129(5):1267-1273.e1. PMID: 22460071.

Szefler SJ, Chinchilli VM, Israel E, Denlinger LC, Lemanske RF Jr, Calhoun W, Peters SP; National Heart, Lung and Blood Institute Asthma Clinical Research Network. Key observations from the NHLBI Asthma Clinical Research Network. Thorax. 2012 May;67(5):450-5. PMID: 22514237.

Wiemer AJ, Wernimont S, Huttenlocher A. Live imaging of LFA-1-dependent T-cell motility and stop signals. Methods Mol Biol. 2012;757:191-204. PMID: 21909914.

Yoo SK, Freisinger CM, LeBert DC, Huttenlocher A. Early redox, Src family kinase, and calcium signaling integrate wound responses and tissue regeneration in zebrafish. J Cell Biol. 2012 Oct 15;199(2):225-34. PMID: 23045550.

Yoo SK, Lam PY, Eichelberg MR, Zasadil L, Bement WM, Huttenlocher A. Role of microtubules in neutrophil polarity and migration in live zebrafish. J Cell Sci. 2012 Sep 19. PMID: 22992461.

Grant Support

Our faculty were principal investigators on the following grants during calendar year 2012.

Principal Investigator Funding Agency Title
Gern, James Schering-Plough Corporation Selective Induction of Pro-Inflammatory Mediators in Asthmatic Subjects Following Experimental Infection with Hurv-16
Gern, James DHHS, PHS, National Institutes of Health Wisconsin Allergy Research Training (WISCART) Program
Gern, James DHHS, PHS, National Institutes of Health Mechanisms of Rhinovirus-Induced Exacerbations of Asthma
Lemanske, Robert DHHS, PHS, National Institutes of Health COAST III – Rhinovirus Infection and Childhood Asthma
Lemanske, Robert DHHS, PHS, National Institutes of Health Investigating Effects of Viral Infection on Lung Development
Lemanske, Robert DHHS, PHS, National Institutes of Health AsthmaNet
Lemanske, Robert Pharmaxis, Ltd. Mannitol Challenge in COAST
Jackson, Daniel UWMF - UW Medical Foundation Epithelial Cell Allergy-Virus Interactions in Asthma
Jackson, Daniel DHHS, PHS, National Institutes of Health Mechanisms Linking Immune Dysregulation (ICTR KL2)
Smith, Judith DHHS, PHS, National Institutes of Health Study of Families with Twins or Siblings Discordant for Rheumatic Disorders
Smith, Judith Multiple Donors Gift for Abstract Being #1
Smith, Judith Arthritis National Research Foundation Excess IL-23 Production and Underlying Biochemical Mechanisms in Ankylosing Spondylitis
Smith, Judith American College of Rheumatology Excess IL-23 Production in Ankylosing Spondylitis and Related Arthritides
Smith, Judith DHHS, PHS, National Institutes of Health Regulation of IFN-Beta Induction by P2X7 Purinergic Receptor Signaling
Huttenlocher, Anna Duke University CARRA Registry
Huttenlocher, Anna Burroughs Wellcome Fund Diagnosis and Treatment of Autoinflammatory Disease
Huttenlocher, Anna DHHS, PHS, National Institutes of Health Neutrophil Chemotaxis in Autoinflammation
Huttenlocher, Anna DHHS, PHS, National Institutes of Health Adhesive Regulation During Cell Migration
Huttenlocher, Anna American Heart Association Greater Midwest Affiliate In Vitro and In Vivo Characterization of Hax1 and HS1 Signaling During Neutrophil Chemotaxis
Huttenlocher, Anna DHHS, PHS, National Institutes of Health Integrated Training for Physician-Scientists
Huttenlocher, Anna DHHS, PHS, National Institutes of Health Understanding Cell Migration Through Microscale In Vitro Models
Huttenlocher, Anna American Heart Association Mechanisms Regulating Neutrophil Migration During Inflammation In Vivo
Huttenlocher, Anna American College of Rheumatology Citrullination in Arthritis
Huttenlocher, Anna DHHS, PHS, National Institutes of Health Cytoskeletal Regulation of T Cell-APC Interactions
Huttenlocher, Anna American Cancer Society, Inc. Functions and Regulation of Focal Adhesion Kinase in Lymphoma
Huttenlocher, Anna DHHS, PHS, National Institutes of Health Reactive Oxygen Species in the Resolution of Inflammation
Huttenlocher, Anna DHHS, PHS, National Institutes of Health A Toolkit for Imaging and Photo-Manipulation of Signaling In Zebrafish
Huttenlocher, Anna American Heart Association Greater Midwest Affiliate Characterization Of Hax1 And HS1 Signaling Mechaisms In Neutrophil Chemotaxis
Seroogy, Christine Midwest Athletes Against Childhood Cancer The Gene Related to Anergy in Lymphocytes, GRAIL, and its Implications in Tumor Anergy
Seroogy, Christine DHHS, PHS, National Institutes of Health-NIOSH administered through University of Minnesota Exploratory Immunologic Differences in Cord Blood from Infants Born into Farming Environments Compared to Nonfarming Environments in MESA

View Other Divisions' Highlights