Division Highlights - Allergy, Immunology & Rheumatology

The Division of Allergy, Immunology, and Rheumatology provides state-of-the-art, evidence-based care for children with asthma, allergies, immunologic disorders, and rheumatologic diseases.

Our basic and clinical research projects are designed to better understand and find more effective treatments for these diseases.

2011 Highlights

  • Anna Huttenlocher, MD, received the Wisconsin Alumni Research Foundation’s Kellett Mid-Career award, which comes with $60,000.
  • Anna Huttenlocher, MD, and James Gern, MD, were elected to the American Association of Physicians.
  • Daniel Jackson, MD, was awarded $50,000 from the UW Institute for Clinical and Translational Research (ICTR) for his one-year pilot grant, “Epithelial Cell Allergy – Virus Interactions in Asthma.”
  • Robert F. Lemanske, Jr., MD, was elected to the Biologic Science Tenure Committee. In addition, Daniel Stoltz, a research assistant in his laboratory, received a 2011-2012 UW Hilldale Undergraduate Research Fellowship.
  • Judith Smith, MD, PhD, received a one-year, $75,000 award from the Arthritis National Research Foundation her project, "Excess IL-23 Production and Underlying Biochemical Mechanisms in Ankylosing Spondylitis (AS)." She also received over $41,000 from the UW Graduate School for her project, "The Interaction of IFN-beta and Endoplasmic Reticulum Stress in Mediating Hepatic Ischemia Reperfusion Injury," and a $10,000 award from the Spondylitis Association of America (SAA).


Robert F. Lemanske, Jr., MD

Professor and Division Chief

Marcus Cohen, MD

Clinical Professor

James E. Gern, MD


Christopher T. Healy, MD

Clinical Associate Professor

Anna Huttenlocher, MD


Daniel J. Jackson, MD

Assistant Professor

Mark H. Moss, MD

Associate Professor

Michael W. Ritter, MD

Associate Professor

Christine M. Seroogy, MD

Associate Professor

Judith A. Smith, MD, PhD

Assistant Professor

Grant D. Syverson, MD

Assistant Professor


Recent Publications

Ali SA, Gern JE, Hartert TV, Edwards KM, Griffin MR, Miller EK, Gebretsadik T, Pappas T, Lee WM, Williams JV. Real-world comparison of two molecular methods for detection of respiratory viruses. Virol J. 2011 Jun 29;8:332. PMID: 21714915.

Bochkov YA, Palmenberg AC, Lee WM, Rathe JA, Amineva SP, Sun X, Pasic TR, Jarjour NN, Liggett SB, Gern JE. Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C. Nat Med. 2011May;17(5):627-32. PMID: 21483405.

Busse WW, Gern JE. Asthma and pregnancy: do they give clues to abnormal antiviral activity? Thorax. 2011 Oct 8. PMID: 21984364.

Busse WW, Morgan WJ, Gergen PJ, Mitchell HE, Gern JE, Liu AH, Gruchalla RS, Kattan M, Teach SJ, Pongracic JA, Chmiel JF, Steinbach SF, Calatroni A, Togias A, Thompson KM, Szefler SJ, Sorkness CA. Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children. N Engl J Med. 2011 Mar 17;364(11):1005-15. PMID: 21410369.

Cavnar PJ, Berthier E, Beebe DJ, Huttenlocher A. Hax1 regulates neutrophil adhesion and motility through RhoA. J Cell Biol. 2011 May 2;193(3):465-73. PMID: 21518791.

Cortesio CL, Boateng LR, Piazza TM, Bennin DA, Huttenlocher A. Calpain-mediated proteolysis of paxillin negatively regulates focal adhesion dynamics and cell migration. J Biol Chem. 2011 Mar 25;286(12):9998-10006. PMID: 21270128.

Deng Q, Harvie EA, Huttenlocher A. Distinct signaling mechanisms mediate neutrophil attraction to bacterial infection and tissue injury. Cell Microbiol. 2011 Dec 20. PMID: 22188170.

Deng Q, Yoo SK, Cavnar PJ, Green JM, Huttenlocher A. Dual roles for Rac2 in neutrophil motility and active retention in zebrafish hematopoietic tissue. Dev Cell. 2011 Oct 18;21(4):735-45. PMID: 22014524.

Denlinger LC, Sorkness RL, Lee WM, Evans MD, Wolff MJ, Mathur SK, Crisafi GM, Gaworski KL, Pappas TE, Vrtis RF, Kelly EA, Gern JE, Jarjour NN. Lower airway rhinovirus burden and the seasonal risk of asthma exacerbation. Am J Respir Crit Care Med. 2011 Nov 1;184(9):1007-14. PMID: 21816938.

Eisenstein EM, Syverson GD, Vora SS, Williams CB. Combination therapy with methotrexate and etanercept for refractory chronic recurrent multifocal osteomyelitis. J Rheumatol. 2011 Apr;38(4):782-3. PMID: 21459961.

Fabian P, Brain J, Houseman EA, Gern J, Milton DK. Origin of exhaled breath particles from healthy and human rhinovirus-infected subjects. J Aerosol Med Pulm Drug Deliv. 2011 Jun;24(3):137-47. PMID: 21361786.

Gavala ML, Bertics PJ, Gern JE. Rhinoviruses, allergic inflammation, and asthma. Immunol Rev. 2011 Jul;242(1):69-90. PMID: 21682739.

Gern JE. Barnyard microbes and childhood asthma. N Engl J Med. 2011 Feb 24;364(8):769-70. PMID: 21345107.

Guilbert TW, Mauger DT, Allen DB, Zeiger RS, Lemanske RF Jr, Szefler SJ, Strunk RC, Bacharier LB, Covar R, Sorkness CA, Taussig LM, Martinez FD; Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. Growth of preschool children at high risk for asthma 2 years after discontinuation of fluticasone. J Allergy Clin Immunol. 2011 Nov;128(5):956-63.e1-7. PMID: 21820163.

Guilbert TW, Singh AM, Danov Z, Evans MD, Jackson DJ, Burton R, Roberg KA, Anderson EL, Pappas TE, Gangnon R, Gern JE, Lemanske RF Jr. Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma. J Allergy Clin Immunol. 2011 Sep;128(3):532-8.e1-10. PMID: 21878241.

Horner CC, Mauger D, Strunk RC, Graber NJ, Lemanske RF Jr, Sorkness CA, Szefler SJ, Zeiger RS, Taussig LM, Bacharier LB; Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. Most nocturnal asthma symptoms occur outside of exacerbations and associate with morbidity. J Allergy Clin Immunol. 2011 Nov;128(5):977-82.e1-2. PMID: 21855126.

Huttenlocher A, Horwitz AR. Integrins in cell migration. Cold Spring Harb Perspect Biol. 2011 Sep 1;3(9). PMID: 21885598.

Jackson DJ, Evans MD, Gangnon RE, Tisler CJ, Pappas TE, Lee WM, Gern JE, Lemanske RF Jr. Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life. Am J Respir Crit Care Med. 2012 Feb 1;185(3):281-5. Epub 2011 Sep 29. PMID: 21960534.

Kloepfer KM, DeMore JP, Vrtis RF, Swenson CA, Gaworski KL, Bork JA, Evans MD, Gern JE. Effects of montelukast on patients with asthma after experimental inoculation with human rhinovirus 16. Ann Allergy Asthma Immunol. 2011 Mar;106(3):252-7. PMID: 21354028.

Lötvall J, Akdis CA, Bacharier LB, Bjermer L, Casale TB, Custovic A, Lemanske RF Jr, Wardlaw AJ, Wenzel SE, Greenberger PA. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol. 2011 Feb;127(2):355-60. PMID: 21281866.

Loisel DA, Tan Z, Tisler CJ, Evans MD, Gangnon RE, Jackson DJ, Gern JE, Lemanske RF Jr, Ober C. IFNG genotype and sex interact to influence the risk of childhood asthma. J Allergy Clin Immunol. 2011 Sep;128(3):524-31. PMID: 21798578.

Martinez FD, Chinchilli VM, Morgan WJ, Boehmer SJ, Lemanske RF Jr, Mauger DT,  Strunk RC, Szefler SJ, Zeiger RS, Bacharier LB, Bade E, Covar RA, Friedman NJ, Guilbert TW, Heidarian-Raissy H, Kelly HW, Malka-Rais J, Mellon MH, Sorkness CA,  Taussig L. Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trial. Lancet. 2011 Feb 19;377(9766):650-7. PMID: 21324520.

Russ AJ, Wentworth L, Xu K, Rakhmilevich A, Seroogy CM, Sondel PM, Suresh M, Cho CS. Suppression of T-cell expansion by melanoma is exerted on resting cells. Ann Surg Oncol. 2011 Dec;18(13):3848-57. PMID: 21465311.

Slattery MJ, Essex MJ, Paletz EM, Vanness ER, Infante M, Rogers GM, Gern JE. Depression, anxiety, and dermatologic quality of life in adolescents with atopic dermatitis. J Allergy Clin Immunol. 2011 Sep;128(3):668-71. PMID: 21684588.

Smith JA. Testing for rheumatological diagnoses in children. Eur Paediatr Rev. 2009;3(1):30-34. PMID: 22059094.

Starnes TW, Cortesio CL, Huttenlocher A. Imaging podosome dynamics and matrix degradation. Methods Mol Biol. 2011;769:111-36. PMID: 21748673.

Tantisira KG, Lasky-Su J, Harada M, Murphy A, Litonjua AA, Himes BE, Lange C,  Lazarus R, Sylvia J, Klanderman B, Duan QL, Qiu W, Hirota T, Martinez FD, Mauger  D, Sorkness C, Szefler S, Lazarus SC, Lemanske RF Jr, Peters SP, Lima JJ, Nakamura Y, Tamari M, Weiss ST. Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med. 2011 Sep 29;365(13):1173-83. PMID: 21991891.

Thomas A, Lemanske RF Jr, Jackson DJ. Approaches to stepping up and stepping down care in asthmatic patients. J Allergy Clin Immunol. 2011 Nov;128(5):915-24; quiz 925-6. PMID: 21855125.

Torgerson DG, Ampleford EJ, Chiu GY, Gauderman WJ, Gignoux CR, Graves PE, Himes BE, Levin AM, Mathias RA, Hancock DB, Baurley JW, Eng C, Stern DA, Celedón JC, Rafaels N, Capurso D, Conti DV, Roth LA, Soto-Quiros M, Togias A, Li X, Myers RA, Romieu I, Van Den Berg DJ, Hu D, Hansel NN, Hernandez RD, Israel E, Salam MT, Galanter J, Avila PC, Avila L, Rodriquez-Santana JR, Chapela R, Rodriguez-Cintron W, Diette GB, Adkinson NF, Abel RA, Ross KD, Shi M, Faruque MU, Dunston GM, Watson HR, Mantese VJ, Ezurum SC, Liang L, Ruczinski I, Ford JG, Huntsman S, Chung KF, Vora H, Li X, Calhoun WJ, Castro M, Sienra-Monge JJ, del Rio-Navarro B, Deichmann KA, Heinzmann A, Wenzel SE, Busse WW, Gern JE, Lemanske RF Jr, Beaty TH, Bleecker ER, Raby BA, Meyers DA, London SJ; Mexico City Childhood Asthma Study (MCAAS), Gilliland FD; Children's Health Study (CHS) and HARBORS study, Burchard EG; Genetics of Asthma in Latino Americans (GALA) Study, Study of Genes-Environment and Admixture in Latino Americans (GALA2) and Study of African Americans, Asthma, Genes & Environments (SAGE), Martinez FD; Childhood Asthma Research and Education (CARE) Network, Weiss ST; Childhood Asthma Management Program (CAMP), Williams LK; Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE), Barnes KC; Genetic Research on Asthma in African Diaspora (GRAAD) Study, Ober C, Nicolae DL. Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet. 2011 Jul 31;43(9):887-92. PMID: 21804549.

Verbsky JW, Baker MW, Grossman WJ, Hintermeyer M, Dasu T, Bonacci B, Reddy S, Margolis D, Casper J, Gries M, Desantes K, Hoffman GL, Brokopp CD, Seroogy CM, Routes JM. Newborn screening for severe combined immunodeficiency; the Wisconsin experience (2008-2011). J Clin Immunol. 2012 Feb;32(1):82-8. Epub 2011 Nov 10. PMID: 22068910.

Wang L, Hollenbeak CS, Mauger DT, Zeiger RS, Paul IM, Sorkness CA, Lemanske RF Jr, Martinez FD, Strunk RC, Szefler SJ, Taussig LM; Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. Cost-effectiveness analysis of fluticasone versus montelukast in children with mild-to-moderate persistent asthma in the Pediatric Asthma Controller Trial. J Allergy Clin Immunol. 2011 Jan;127(1):161-6, 166.e1. PMID: 21211651.

Wernimont SA, Wiemer AJ, Bennin DA, Monkley SJ, Ludwig T, Critchley DR, Huttenlocher A. Contact-dependent T cell activation and T cell stopping require talin1. J Immunol. 2011 Dec 15;187(12):6256-67. PMID: 22075696.

Wiemer AJ, Hegde S, Gumperz JE, Huttenlocher A. A live imaging cell motility screen identifies prostaglandin E2 as a T cell stop signal antagonist. J Immunol. 2011 Oct 1;187(7):3663-70. PMID: 21900181.

Wood RA, Bloomberg GR, Kattan M, Conroy K, Sandel MT, Dresen A, Gergen PJ, Gold DR, Schwarz JC, Visness CM, Gern JE. Relationships among environmental exposures, cord blood cytokine responses, allergy, and wheeze at 1 year of age in an inner-city birth cohort (Urban Environment and Childhood Asthma study). J Allergy Clin Immunol. 2011 Apr;127(4):913-9.e1-6. PMID: 21333343.

Yoo SK, Huttenlocher A. Spatiotemporal photolabeling of neutrophil trafficking during inflammation in live zebrafish. J Leukoc Biol. 2011 May;89(5):661-7. PMID: 21248150.

Yoo SK, Starnes TW, Deng Q, Huttenlocher A. Lyn is a redox sensor that mediates leukocyte wound attraction in vivo. Nature. 2011 Nov 20;480(7375):109-12. PMID: 22101434.

Young EW, Berthier E, Guckenberger DJ, Sackmann E, Lamers C, Meyvantsson I, Huttenlocher A, Beebe DJ. Rapid prototyping of arrayed microfluidic systems in polystyrene for cell-based assays. Anal Chem. 2011 Feb 15;83(4):1408-17. PMID: 21261280.

Zeiger RS, Mauger D, Bacharier LB, Guilbert TW, Martinez FD, Lemanske RF Jr, Strunk RC, Covar R, Szefler SJ, Boehmer S, Jackson DJ, Sorkness CA, Gern JE, Kelly HW, Friedman NJ, Mellon MH, Schatz M, Morgan WJ, Chinchilli VM, Raissy HH, Bade E, Malka-Rais J, Beigelman A, Taussig LM; CARE Network of the National Heart, Lung, and Blood Institute. Daily or intermittent budesonide in preschool children with recurrent wheezing. N Engl J Med. 2011 Nov 24;365(21):1990-2001. PMID: 22111718.

Zeng L, Lindstrom MJ, Smith JA. Ankylosing spondylitis macrophage production of higher levels of interleukin-23 in response to lipopolysaccharide without induction of a significant unfolded protein response. Arthritis Rheum. 2011 Dec;63(12):3807-17. PMID: 22127699.

Grant Support

Principal Investigator Funding Agency Title
Cohen, Marcus Covance, Inc. An Epidemiologic Study of Xolair (Omalizumab): Evaluating Clinical Effectiveness and Long-Term Safety in Patients with Moderate to Severe Asthma (EXCELS)
Gern, James DHHS, PHS, National Institutes of Health Mechanisms of Rhinovirus-Induced Exacerbations of Asthma
Gern, James DHHS, PHS, National Institutes of Health Wisconsin Allergy Research Training (WISCART) Program
Gern, James University of Texas Health Science Center Mutant Mice with Conditional Alleles of Tlr2, Tlr4 and Tlr9
Huttenlocher, Anna American College of Rheumatology ACR REF Rheumatology Scientist Development Award (Shelef)
Huttenlocher, Anna American Heart Association In Vitro and In Vivo Characterization of Hax1 and HS1 Signaling During Neutrophil Xhemotaxis (Cavnar Post-doctoral Fellowship)
Huttenlocher, Anna American Heart Association Mechanisms Regulating Neutrophil Migration During Inflammation In Vivo (Yoo Predoctoral Fellowship)
Huttenlocher, Anna Burroughs Wellcome Fund Diagnosis and Treatment of Autoinflammatory Disease
Huttenlocher, Anna DHHS, PHS, National Institutes of Health Adhesive Regulation During Cell Migration
Huttenlocher, Anna DHHS, PHS, National Institutes of Health Neutrophil Chemotaxis in Autoinflammation
Huttenlocher, Anna DHHS, PHS, National Institutes of Health Understanding Cell Migration Through Microscale In Vitro Models
Huttenlocher, Anna Duke University CARRA Registry
Huttenlocher, Anna National Science Foundation EFRI-MIKS: Microfluidic-Based Screening of Multi-Kingdom Microbial Communication Molecules
Huttenlocher, Anna Wisconsin Alumni Research Foundation Kellett Mid-Career Faculty Research
Jackson, Daniel DHHS, PHS, National Institutes of Health Mechanisms Linking Immune Dysregulation, Allergy, Viruses, and Childhood Asthma (ICTR KL2)
Jackson, Daniel UWMF - UW Medical Foundation Epithelial Cell Allergy-Virus Interactions in Asthma (ICTR Pilot)
Lemanske, Robert DHHS, PHS, National Institutes Of Health AsthmaNet
Lemanske, Robert DHHS, PHS, National Institutes Of Health CARE Network - Madison Clinical Center
Lemanske, Robert DHHS, PHS, National Institutes Of Health Investigating Effects of Viral Infection on Lung Development
Lemanske, Robert DHHS, PHS, National Institutes Of Health Rhinovirus Infections and Childhood Asthma (COAST)
Lemanske, Robert DHHS, PHS, National Institutes Of Health Treatment of Severe Persistent Asthma (ACRN)
Lemanske, Robert Genentech, Inc Genentech ILR4646g
Lemanske, Robert Pennsylvania State University AsthmaNet April-Ocelot, Bacterial Mechanistic
Lemanske, Robert Pharmaxis, Ltd Mannitol Challenge in COAST
Lemanske, Robert University of Arizona The Asthma BioRepository for Integrative Genomics Research
Lemanske, Robert University of California - San Diego MIA & PAX ACQ Validation Study
Seroogy, Christine Midwest Athletes Against Childhood Cancer The Gene Related to Anergy in Lymphocytes, GRAIL, in CD25+ T Regulatory Cell Biology
Seroogy, Christine UWMF - UW Medical Foundation T Regulatory Cells and Childhood Asthma (ICTR Pilot)
Smith, Judith Arthritis National Research Foundation Excell IL-23 Production and Underlying Biochemical Mechanisms in Ankylosing Spondylitis
Smith, Judith DHHS, PHS, National Institutes Of Health Regulation of IFN-beta Induction by P2X7 Purinergic Receptor Signaling
Smith, Judith Wisconsin Alumni Research Foundation Grad School Fall Competition

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