The Division of Infectious Disease cares for children with common, complex, or potentially life-threatening infectious diseases and illnesses.Research interests include international health, immunization efficacy, vaccine preventable disease epidemiology and policy, respiratory tract infections, urinary tract infections, and fungal infections.
Bruce Klein, MD, was elected into the American Pediatrics Society, and was also elected vice chair (2013) and chair (2015) of the new Gordon Research Conference on Fungal Immunology.
Dr. Klein was also awarded $750,000 annually for three years as co-investigator of “Discovery of Natural Product-Based Drugs From Bacterial Symbionts of Insects,” a new NIH RC4 Challenge Grant. The project is part of a drug discovery initiative spawned by the Wisconsin Center for Infectious Disease.
- Ellen Wald, MD, was awarded $355,569 over three years from the Thrasher Research Fund to study short-course versus long-course antibiotics for the treatment of acute bacterial sinusitis in children. Greg DeMuri, MD, is the study’s co-investigator.
Professor and Division Chief
DeMuri GP, Wald ER. Acute sinusitis: clinical manifestations and treatment approaches. Pediatr Ann. 2010 Jan;39(1):34-40.
Edmonson MB, Riedesel EL, Williams GP, DeMuri GP. Generalized petechial rashes in children during a parvovirus B19 outbreak. Pediatrics. 2010 Apr;125(4):e787-92.
Ersland K, Wüthrich M, Klein BS. Dynamic interplay among monocyte-derived, dermal, and resident lymph node dendritic cells during the generation of vaccine immunity to fungi. Cell Host Microbe. 2010 Jun 25;7(6):474-87.
Gauthier GM, Sullivan TD, Gallardo SS, Brandhorst TT, Vanden Wymelenberg AJ, Cuomo CA, Suen G, Currie CR, Klein BS. SREB, a GATA transcription factor that directs disparate fates in Blastomyces dermatitidis including morphogenesis and siderophore biosynthesis. PLoS Pathog. 2010 Apr 1;6(4):e1000846.
Krajaejun T, Wüthrich M, Gauthier GM, Warner TF, Sullivan TD, Klein BS. Discordant influence of Blastomyces dermatitidis yeast-phase-specific gene BYS1 on morphogenesis and virulence. Infect Immun. 2010 Jun;78(6):2522-8.
Pfister JR, Archer JR, Hersil S, Boers T, Reed KD, Meece JK, Anderson JL, Burgess JW, Sullivan TD, Klein BS, Wheat LJ, Davis JP. Non-rural point source blastomycosis outbreak near a yard waste collection site. Clin Med Res. 2010 Oct 25.
Huppler AR, Eickhoff JC, Wald ER. Performance of low-risk criteria in the evaluation of young infants with fever: review of the literature. Pediatrics. 2010 Feb;125(2):228-33.
Shaikh N, Wald ER, Pi M. Decongestants, antihistamines and nasal irrigation for acute sinusitis in children. Cochrane Database Syst Rev. 2010 Dec 8;(12):CD007909.
|Principal Investigator||Funding Agency||Title|
|Conway, James||Sanofi Pasteur||Surveillance for Rates of Pertussis Disease Among Persons Birth Through 59 Months of Age Receiving Pentacel or Other Pertussis Vaccines|
|Conway, James||Indiana University||Kenya Immunization Managers' Training Programme through Global Training Network|
|Klein, Bruce||DHHS, PHS, National Institutes of Health||Mechanisms of Anti-Fungal Vaccine Immunity|
|Klein, Bruce||DHHS, PHS, National Institutes of Health||Molecular Pathogenesis of Blastomycosis|
|Klein, Bruce||DHHS, PHS, National Institutes of Health||Targeting Hybrid Histidine Kinase for Broad Spectrum Antifungal Therapy|
|Klein, Bruce||DHHS, PHS, National Institutes of Health||Microbes in Health and Disease Training Program|
|Klein, Bruce||DHHS, PHS, National Institutes of Health||Environmental Chitin Exposure in the Pathogenesis of Asthma (Predoctoral support for MSTP student Rene Roy; Klein, Sponsor)|
|Klein, Bruce||The Hartwell Foundation||Stemming the Growing Tide of Systemic Fungal Infections in Children|
|Klein, Bruce||The Hartwell Foundation||J. Carmen Postdoctoral Fellowship (Klein, Sponsor)|
|Klein, Bruce||UWF - Wisconsin Partnership Program - MERC||Wisconsin Infectious Disease Drug Discovery|
|Klein, Bruce||UWF - Wisconsin Partnership Program - MERC||Wisconsin Center for Infectious Disease (WisCID)|
|Klein, Bruce||Sandler Program for Asthma Research||The Chitin Receptor and its Role in Asthma Pathogenesis|
|Wald, Ellen||GlaxoSmithKline||A Phase 3, Randomized, Multicenter Study, Double-Blind For The Immunogenicity and Consistency Evaluation of 3 Lots of GSK Biologicals' Haemophilus Influenzae Type B (Hib) Conjugate Vaccine|
|Wald, Ellen||University of Pittsburgh||Diagnosing Acute Bacterial Sinusitis in Children and Measuring Treatment Response|
|Wald, Ellen||University of Pittsburgh||Efficacy of Prophylactic Antimicrobials in Children with Vesicoureteral Reflux|
|Wald, Ellen||Medimmune, Inc.||An Observational Prospective Study to Assess Respiratory Syncytial Virus (RSV) Respiratory Events Among Premature Infants (32 to 35 Week Gestational Age) - Outcomes and Risk Tracking Study (The Report Study)|
|Wald, Ellen||Merck and Company, Inc.||Protocol V503-005: The Immunogenicity and Tolerability of V503 Given Concomitantly with Menactra & Adacel in Preadolescents (11 to 15 year olds)|
|Wald, Ellen||Thrasher Research Fund||Short (5 days) versus Long (14 days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in Children|
|Wuethrich, Marcel||DHHS, PHS, National Institutes of Health||Priming of Antifungal T-Cells At Mucosal and Systemic Sites|
|Wuethrich, Marcel||DHHS, PHS, National Institutes of Health||Regulation of Vaccine-Induced Anti-Fungal T17 Cells|