Division Highlights - Infectious Disease

The Division of Infectious Disease cares for children with common, complex, or potentially life-threatening infectious diseases and illnesses.

Research interests include international health, immunization efficacy, vaccine preventable disease epidemiology and policy, respiratory tract infections, urinary tract infections, and fungal infections.

2010 Highlights

  • Bruce Klein, MD, was elected into the American Pediatrics Society, and was also elected vice chair (2013) and chair (2015) of the new Gordon Research Conference on Fungal Immunology.

    Dr. Klein was also awarded $750,000 annually for three years as co-investigator of “Discovery of Natural Product-Based Drugs From Bacterial Symbionts of Insects,” a new NIH RC4 Challenge Grant. The project is part of a drug discovery initiative spawned by the Wisconsin Center for Infectious Disease.
  • Ellen Wald, MD, was awarded $355,569 over three years from the Thrasher Research Fund to study short-course versus long-course antibiotics for the treatment of acute bacterial sinusitis in children. Greg DeMuri, MD, is the study’s co-investigator.

Faculty


Bruce S. Klein, MD

Professor and Division Chief

James H. Conway, MD

Associate Professor

Gregory P. DeMuri, MD

Associate Professor

Ellen R. Wald, MD

Professor

Recent Publications

DeMuri GP, Wald ER. Acute sinusitis: clinical manifestations and treatment approaches. Pediatr Ann. 2010 Jan;39(1):34-40.

Edmonson MB, Riedesel EL, Williams GP, DeMuri GP. Generalized petechial rashes in children during a parvovirus B19 outbreak. Pediatrics. 2010 Apr;125(4):e787-92.

Ersland K, Wüthrich M, Klein BS. Dynamic interplay among monocyte-derived, dermal, and resident lymph node dendritic cells during the generation of vaccine immunity to fungi. Cell Host Microbe. 2010 Jun 25;7(6):474-87.

Gauthier GM, Sullivan TD, Gallardo SS, Brandhorst TT, Vanden Wymelenberg AJ, Cuomo CA, Suen G, Currie CR, Klein BS. SREB, a GATA transcription factor that directs disparate fates in Blastomyces dermatitidis including morphogenesis and siderophore biosynthesis. PLoS Pathog. 2010 Apr 1;6(4):e1000846.

Krajaejun T, Wüthrich M, Gauthier GM, Warner TF, Sullivan TD, Klein BS. Discordant influence of Blastomyces dermatitidis yeast-phase-specific gene BYS1 on morphogenesis and virulence. Infect Immun. 2010 Jun;78(6):2522-8.

Pfister JR, Archer JR, Hersil S, Boers T, Reed KD, Meece JK, Anderson JL, Burgess JW, Sullivan TD, Klein BS, Wheat LJ, Davis JP. Non-rural point source blastomycosis outbreak near a yard waste collection site. Clin Med Res. 2010 Oct 25.

Huppler AR, Eickhoff JC, Wald ER. Performance of low-risk criteria in the evaluation of young infants with fever: review of the literature. Pediatrics. 2010 Feb;125(2):228-33.

Shaikh N, Wald ER, Pi M. Decongestants, antihistamines and nasal irrigation for acute sinusitis in children. Cochrane Database Syst Rev. 2010 Dec 8;(12):CD007909.

Grant Support


Principal Investigator Funding Agency Title
Conway, James Sanofi Pasteur Surveillance for Rates of Pertussis Disease Among Persons Birth Through 59 Months of Age Receiving Pentacel or Other Pertussis Vaccines
Conway, James Indiana University Kenya Immunization Managers' Training Programme through Global Training Network
Klein, Bruce DHHS, PHS, National Institutes of Health Mechanisms of Anti-Fungal Vaccine Immunity
Klein, Bruce DHHS, PHS, National Institutes of Health Molecular Pathogenesis of Blastomycosis
Klein, Bruce DHHS, PHS, National Institutes of Health Targeting Hybrid Histidine Kinase for Broad Spectrum Antifungal Therapy
Klein, Bruce DHHS, PHS, National Institutes of Health Microbes in Health and Disease Training Program
Klein, Bruce DHHS, PHS, National Institutes of Health Environmental Chitin Exposure in the Pathogenesis of Asthma (Predoctoral support for MSTP student Rene Roy; Klein, Sponsor)
Klein, Bruce The Hartwell Foundation Stemming the Growing Tide of Systemic Fungal Infections in Children
Klein, Bruce The Hartwell Foundation J. Carmen Postdoctoral Fellowship (Klein, Sponsor)
Klein, Bruce UWF - Wisconsin Partnership Program - MERC Wisconsin Infectious Disease Drug Discovery
Klein, Bruce UWF - Wisconsin Partnership Program - MERC Wisconsin Center for Infectious Disease (WisCID)
Klein, Bruce Sandler Program for Asthma Research The Chitin Receptor and its Role in Asthma Pathogenesis
Wald, Ellen GlaxoSmithKline A Phase 3, Randomized, Multicenter Study, Double-Blind For The Immunogenicity and Consistency Evaluation of 3 Lots of GSK Biologicals' Haemophilus Influenzae Type B (Hib) Conjugate Vaccine
Wald, Ellen University of Pittsburgh Diagnosing Acute Bacterial Sinusitis in Children and Measuring Treatment Response
Wald, Ellen University of Pittsburgh Efficacy of Prophylactic Antimicrobials in Children with Vesicoureteral Reflux
Wald, Ellen Medimmune, Inc. An Observational Prospective Study to Assess Respiratory Syncytial Virus (RSV) Respiratory Events Among Premature Infants (32 to 35 Week Gestational Age) - Outcomes and Risk Tracking Study (The Report Study)
Wald, Ellen Merck and Company, Inc. Protocol V503-005: The Immunogenicity and Tolerability of V503 Given Concomitantly with Menactra & Adacel in Preadolescents (11 to 15 year olds)
Wald, Ellen Thrasher Research Fund Short (5 days) versus Long (14 days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in Children
Wuethrich, Marcel DHHS, PHS, National Institutes of Health Priming of Antifungal T-Cells At Mucosal and Systemic Sites
Wuethrich, Marcel DHHS, PHS, National Institutes of Health Regulation of Vaccine-Induced Anti-Fungal T17 Cells

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