Division Highlights - Allergy, Immunology & Rheumatology

The Division of Allergy, Immunology, and Rheumatology provides outstanding care for children with asthma, allergies, and rheumatologic diseases.

Our research aims to better understand and find more effective treatments for these diseases.

2009 Highlights

  • Robert Lemanske, MD, received a prestigious NIH network grant, “AsthmaNet,” to study new and innovative therapies for asthma. This cooperative agreement is funded through June 2016 and provides a total award amount of 5.5 million.
  • James Gern, MD, was awarded NIH funding of $408,456 over two years and $25,964 from The Baylor College of Medicine.
  • Christine Seroogy, MD, was awarded $50,000 from the Midwest Athletes Against Childhood Cancer (MACC) fund.
  • Judith Smith, MD, PhD, was awarded an NIH Career Development Award of $419,481 over three years.
  • Fellow Dan Jackson, MD, received a $50,000 American Academy of Allergy, Asthma and Immunology GSK Fellows Career Development Award.


Robert F. Lemanske, Jr., MD


Marcus Cohen, MD

Clinical Professor

James E. Gern, MD


Christopher T. Healy, MD

Clinical Assistant Professor

Anna Huttenlocher, MD


Mark H. Moss, MD

Associate Professor

Michael W. Ritter, MD

Associate Professor

Christine M. Seroogy, MD

Assistant Professor

Judith A. Smith, MD, PhD

Assistant Professor


Recent Publications

Abman S, Jobe A, Chernick V, Blaisdell C, Castro M, Ramirez MI, Gern JE, Cutting G, Redding G, Hagood JS, Whitsett J, Abman S, Raj JU, Barst R, Kato GJ, Gozal D, Haddad GG, Prabhakar NR, Gauda E, Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FS, Wright RJ, Gail D, Hamvas A, Kercsmar C, Kiley J, Weinmann G; NHLBI working group report. Strategic plan for pediatric respiratory diseases research: an NHLBI working group report. Pediatr Pulmonol. 2009 Jan;44(1):2-13 (dual publication).

Bacharier LB, Guilbert TW, Zeiger RS, Strunk RC, Morgan WJ, Lemanske RF Jr, Moss M, Szefler SJ, Krawiec M, Boehmer S, Mauger D, Taussig LM, Martinez FD; Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. Patient characteristics associated with improved outcomes with use of an inhaled corticosteroid in preschool children at risk for asthma. J Allergy Clin Immunol. 2009 May;123(5):1077-82, 1082.e1-5. Epub 2009 Feb 23.

Brannon MK, Davis JM, Mathias JR, Hall CJ, Emerson JC, Crosier PS, Huttenlocher A, Ramakrishnan L, Moskowitz SM. Pseudomonas aeruginosa Type III secretion system interacts with phagocytes to modulate systemic infection of zebrafish embryos. Cell Microbiol. 2009 Feb 6. [Epub ahead of print]

Braun RK, Molitor-Dart M, Wigfield C, Xiang Z, Fain SB, Jankowska-Gan E, Seroogy CM, Burlingham WJ, Wilkes DS, Brand DD, Torrealba J, Love RB. Transfer of tolerance to collagen type V suppresses T-helper-cell-17 lymphocyte-mediated acute lung transplant rejection. Transplantation. 2009 Dec 27;88(12):1341-8.

Busse WW, Lemanske RF Jr. The placebo effect in asthma: Far more complex than simply "I shall please". J Allergy Clin Immunol. 2009 Sep;124(3):445-6.

Castro M, Ramirez MI, Gern JE, Cutting G, Redding G, Hagood JS, Whitsett J, Abman S, Raj JU, Barst R, Kato GJ, Gozal D, Haddad GG, Prabhakar NR, Gauda E, Martinez FD, Tepper R, Wood RE, Accurso F, Teague WG, Venegas J, Cole FS, and Wright RJ. Strategic plan for pediatric respiratory diseases research: an NHLBI Working Group report. Proceeding of the American Thoracic Society 2009;6:1-10 (dual publication).

Chan KT, Cortesio CL, Huttenlocher A. FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion. J Cell Biol. 2009 Apr 20;185(2):357-70. Epub 2009 Apr 13.

Cortesio CL, Perrin BJ, Bennin DA, Huttenlocher A. Actin-binding protein-1 interacts with WASp-interacting protein to regulate growth factor-induced dorsal ruffle formation. Mol Biol Cell. 2010 Jan;21(1):186-97. Epub 2009 Nov 12.

DeLay ML, Turner MJ, Klenk EI, Smith JA, Sowders DP, Colbert RA. HLA-B27 misfolding and the unfolded protein response augment interleukin-23 production and are associated with Th17 activation in transgenic rats. Arthritis Rheum. 2009 Sep;60(9):2633-43.

DeMore JP, Weisshaar EH, Vrtis RF, Swenson CA, Evans MD, Morin A, Hazel E, Bork JA, Kakumanu S, Sorkness R, Busse WW, and Gern JE. Similar colds in allergic asthma subjects and non-atopic subjects after inoculation with rhinovirus-16. J Allergy Clin Immunol 2009; 124(2):245-52.

Denlinger LC, Shi L, Guadarrama A, Schell K, Green D, Morrin A, Hogan K, Sorkness RL, Busse WW, and Gern JE. Attenuated P2X7 pore function as a risk factor for virus induced loss of asthma control. Am J Respir Crit Care Med 2009;179:265-270.

Dodd ME, Hatzold J, Mathias JR, Walters KB, Bennin DA, Rhodes J, Kanki JP, Look AT, Hammerschmidt M, Huttenlocher A. The ENTH domain protein Clint1 is required for epidermal homeostasis in zebrafish. Development. 2009 Aug;136(15):2591-600. Epub 2009 Jul 1.

Gern JE and Busse WW. Learning from molecular sleuths (Editorial). J Allergy Clin Immunol 2009;123:105-6.

Gern JE, Visness CM, Gergen PJ, Wood RA, Bloomberg GR, O’Connor GT, Kattan M, Sampson HA, Witter FR, Sandel MT, Shreffler WG, Wright RJ, Arbes SJ, Busse WW. The Urban Environment and Childhood Asthma Study (URECA): Design, methods, and characteristics of the study population. BMC Pulmonary Medicine 2009, 9:17.

Gern JE. Rhinovirus and the initation of asthma. Curr Opin Allergy Clin Immunol 2009;9:73-78.

Ghildyal R, Jordan B, Li D, Dagher H, Bardin PG, Gern JE, Jans DA. Rhinovirus 3C protease can localize in the nucleus and alter active and passive nucleocytoplasmic transport. J Virol. 2009 Jul;83(14):7349-52.

Gold DR, Bloomberg GR, Cruikshank WW, Visness CM, Schwarz J, Kattan M, O’Connor GT, Wood RA, Burger MS, Wright RJ, Witter F, Lee-Paritz A, Sperling R, Sadovsky Y, Togias A, and Gern JE. Parental characteristics, somatic fetal growth, and season of birth influence innate and adaptive cord blood cytokine responses. J Allergy Clin Immunol. 2009;124(5):1078-87.

Gruenberg DA, Añover-Sombke S, Gern JE, Holland SM, Rosenzweig SD, Torgerson TR, Seroogy CM. Atypical presentation of IL-12 receptor beta1 deficiency with pneumococcal sepsis and disseminated nontuberculous mycobacterial infection in a 19-month-old girl born to nonconsanguineous US residents. J Allergy Clin Immunol. 2010 Jan;125(1):264-5. Epub 2009 Nov 11.

Itoh Y, Shinya K, Kiso M, Watanabe T, Sakoda Y, Hatta M, Muramoto Y, Tamura D, Sakai-Tagawa Y, Noda T, Sakabe S, Imai M, Hatta Y, Watanabe S, Li C, Yamada S, Fujii K, Murakami S, Imai H, Kakugawa S, Ito M, Takano R, Iwatsuki-Horimoto K, Shimojima M, Horimoto T, Goto H, Takahashi K, Makino A, Ishigaki H, Nakayama M, Okamatsu M, Takahashi K, Warshauer D, Shult PA, Saito R, Suzuki H, Furuta Y, Yamashita M, Mitamura K, Nakano K, Nakamura M, Brockman-Schneider R, Mitamura H, Yamazaki M, Sugaya N, Suresh M, Ozawa M, Neumann G, Gern J, Kida H, Ogasawara K, Kawaoka Y. In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses. Nature 2009;460(7258):1021-5.

Jackson DJ, Virnig CM, Gangnon RE, Evans MD, Roberg KA, Anderson EL, Burton RM, Salazar LP, DaSilva DF, Shanovich KM, Tisler CJ, Gern JE, Lemanske RFJr. Fractional exhaled nitric oxide (FeNO) measurements are most closely associated with allergic sensitization in school aged children. J Allergy Clin Immunol. 2009;124(5):949-53.

Kim D, Lokuta MA, Huttenlocher A, Beebe DJ. Selective and tunable gradient device for cell culture and chemotaxis study. Lab Chip. 2009 Jun 21;9(12):1797-800. Epub 2009 Mar 26.

Knuffman JE, Sorkness CA, Lemanske RF Jr, Mauger DT, Boehmer SJ, Martinez FD, Bacharier LB, Strunk RC, Szefler SJ, Zeiger RS, Taussig LM; Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. Phenotypic predictors of long-term response to inhaled corticosteroid and leukotriene modifier therapies in pediatric asthma. J Allergy Clin Immunol. 2009 Feb;123(2):411-6. Epub 2009 Jan 3.

Larsen GL, Morgan W, Heldt GP, Mauger DT, Boehmer SJ, Chinchilli VM, Lemanske RF Jr, Martinez F, Strunk RC, Szefler SJ, Zeiger RS, Taussig LM, Bacharier LB, Guilbert TW, Radford S, Sorkness CA; Childhood Asthma Research and Education Network of the National Heart, Lung, and Blood Institute. Impulse oscillometry versus spirometry in a long-term study of controller therapy for pediatric asthma. J Allergy Clin Immunol. 2009 Apr;123(4):861-7.e1. Epub 2008 Dec 12.

Lemanske RF Jr. Asthma therapies revisited: what have we learned? Proc Am Thorac Soc. 2009 May 1;6(3):312-5. Review. PubMed PMID: 19387036; PubMed Central PMCID: PMC2677407.

Ly NP, Ruiz-Perez B, McLoughlin RM, Visness CM, Wallace PK, Cruikshank WW, Tzianabos AO, O’Connor GT, Gold DR, and Gern JE. Characterization of regulatory T cells in urban newborns of allergic parents. Clinical and Molecular Allergy 2009, 7:8.

MacKenzie DA, Seroogy CM. Sustained expression of GRAIL during hematopoiesis results in dysregulated differentiation. Acta Haematol. 2009;122(4):230-7. Epub 2009 Oct 30.

Mathias JR, Dodd ME, Walters KB, Yoo SK, Ranheim EA, Huttenlocher A. Characterization of zebrafish larval inflammatory macrophages. Dev Comp Immunol. 2009 Nov;33(11):1212-7. Epub 2009 Jul 29.

Mathias JR, Walters KB, Huttenlocher A. Neutrophil motility in vivo using zebrafish. Methods Mol Biol. 2009;571:151-66.

Matthew J, Pereira LMP, Pappas TE, Swenson CA, Grindle KA, Roberg KA, Lemanske RF Jr, Lee W-M, and Gern JE. Distribution and seasonality of rhinovirus and other respiratory viruses in a cross-section of asthmatic children in Trinidad, West Indies. Riv Ital Pediatr. 2009 Jun 25;35(1):16.

Quinn BJ, Welch EJ, Kim AC, Lokuta MA, Huttenlocher A, Khan AA, Kuchay SM, Chishti AH. Erythrocyte scaffolding protein p55/MPP1 functions as an essential regulator of neutrophil polarity. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19842-7. Epub 2009 Nov 6.

Rosenthal LA, Amineva SP, Szakaly RJ, Lemanske RF Jr, Gern JE, Sorkness RL. A rat model of picornavirus-induced airway infection and inflammation. Virol J. 2009 Aug 11;6:122.

Schartner JM, Simonson WT, Wernimont SA, Nettenstrom LM, Huttenlocher A, Seroogy CM. Gene related to anergy in lymphocytes (GRAIL) expression in CD4+ T cells impairs actin cytoskeletal organization during T cell/antigen-presenting cell interactions. J Biol Chem. 2009 Dec 11;284(50):34674-81. Epub 2009 Oct 15.

Schartner JM, Singh AM, Dahlberg PE, Nettenstrom L, Seroogy CM. Recurrent superantigen exposure in vivo leads to highly suppressive CD4+CD25+ and CD4+CD25- T cells with anergic and suppressive genetic signatures. Clin Exp Immunol. 2009 Feb;155(2):348-56. Epub 2008 Nov 25.

Simonson WT, Markovina S, Grossman WJ, Lokuta MA, Doan AT, Seroogy CM, Huttenlocher A. Common variable immunodeficiency with regulatory T-cell deficiency treated with rapamycin. Ann Allergy Asthma Immunol. 2009 Feb;102(2):170-1.

Szabady RL, Lokuta MA, Walters KB, Huttenlocher A, Welch RA. Modulation of neutrophil function by a secreted mucinase of Escherichia coli O157:H7. PLoS Pathog. 2009 Feb;5(2):e1000320. Epub 2009 Feb 27.

Walters KB, Dodd ME, Mathias JR, Gallagher AJ, Bennin DA, Rhodes J, Kanki JP, Look AT, Grinblat Y, Huttenlocher A. Muscle degeneration and leukocyte infiltration caused by mutation of zebrafish Fad24. Dev Dyn. 2009 Jan;238(1):86-99.

Wechsler ME, Kunselman SJ, Chinchilli VM, Bleecker E, Boushey HA, Calhoun WJ, Ameredes BT, Castro M, Craig TJ, Denlinger L, Fahy JV, Jarjour N, Kazani S, Kim S, Kraft M, Lazarus SC, Lemanske RF Jr, Markezich A, Martin RJ, Permaul P, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Walter MJ, Wasserman SI, Israel E; National Heart, Lung and Blood Institute's Asthma Clinical Research Network. Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial. Lancet. 2009 Nov 21;374(9703):1754-64.

Wiemer AJ, Lokuta MA, Surfus JC, Wernimont SA, Huttenlocher A. Calpain inhibition impairs TNF-alpha-mediated neutrophil adhesion, arrest and oxidative burst. Mol Immunol. 2010 Jan;47(4):894-902. Epub 2009 Nov 3.

Yoo SK, Huttenlocher A. Innate immunity: wounds burst H2O2 signals to leukocytes. Curr Biol. 2009 Jul 28;19(14):R553-5. Review.

Grant Support

Principal Investigator Funding Agency Title
Cohen, Marcus Covance, Inc. An Epidemiologic Study of Xolair (Omalizumab): Evaluating Clinical Effectiveness and Long-Term Safety in Patients with Moderate to Severe Asthma (EXCELS)
Gern, James DHHS, PHS, National Institutes of Health T Regulatory Cells and Childhood Asthma
Gern, James DHHS, PHS, National Institutes of Health Mechanisms of Rhinovirus-Induced Exacerbations of Asthma
Gern, James DHHS, PHS, National Institutes of Health WI Allergy & Immunology Training Grant
Gern, James; Lee, Wai-Ming University of Virginia AADCRC (Collaboration with Peter Heyman)
Huttenlocher, Anna DHHS, PHS, National Institutes of Health Neutrophil Chemotaxis in Autoinflammation
Huttenlocher, Anna DHHS, PHS, National Institutes of Health Adhesive Regulation During Cell Migration
Huttenlocher, Anna DHHS, PHS, National Institutes of Health Regulation of Mast Cell Function by Inhibitory Molecules
Huttenlocher, Anna DOD, Army Regulation of Invadopodia Formation and Dynamics On Bre
Huttenlocher, Anna Bellbrook Labs, LLC A Microfluidic Chemotaxis High Throughput System
Lemanske, Robert DHHS, PHS, National Institutes of Health Care Network Clinical Center
Lemanske, Robert DHHS, PHS, National Institutes of Health Rhinovirus Infections and Childhood Asthma
Seroogy, Christine UWF - Wisconsin Partnership - MERC Elucidating The Role of Grail In CD25+ T Reg Cell Biological Function
Smith, Judith Wisconsin Alumni Research Foundation HLA-B27 and Inflammatory Cytokine Production In Macrophages
Smith, Judith UW - ICTR ER Stress and Cytokines in Ankylosing Spondylitis
Smith, Judith UWF - University of Wisconsin Foundation SMPH Dean's Scholar
Smith, Judith Novartis ACZ885 In Patients with Muckle-Wells Syndrome
Smith, Judith Novartis An Open-Label, Long-Term Safety and Efficacy Study of ACZ885