Division Highlights - Neonatology

2007 - 2008 Highlights

Georgia Ditzenberger, PhD, NP, and De-Ann Pillers, MD, join division

Pamela Kling, MD, awarded NIH supplement

Overview

The Division of Neonatology promotes the health and well-being of the newly born infant, whether critically ill, premature, or simply in need of special observation or an extended hospital stay.

Our mission includes educating residents and medical students, supporting the community through continuing education opportunities, and advancing patient care through research.

Basic and translational research interests include: genetic contributors to premature birth, chronic lung disease of prematurity, infection and inflammation, infant nutrition, iron metabolism, respiratory drive, physiology vascular adaptations in pregnancy, and vision research. Clinical research interests include psychophysiological neonatal patterns, studies on patients returning to the follow-up clinic, and models and methods of maternal-infant health care delivery.

Ongoing epidemiology projects use an extensive regional and statewide perinatal database to include all phases of perinatal health care, including neonatal follow-up. Residents may also pursue perinatal ethics training through the Department of Pediatrics’ strong medical ethics program.

Faculty

Division Chief: De-Ann M. Pillers, MD, PhD, Professor Georgia R. Ditzenberger, NNP, RNC, PhD, Assistant Professor

De-Ann M. Pillers, MD, PhD

Residency: Doernbecher Memorial Hospital for Children, The Oregon Health Sciences University, Portland, OR

Fellowships: Neonatal-Perinatal Medicine at Doernbecher Memorial Hospital for Children, The Orgeon Heath Sciences University, Portland, OR

Clinical interests: non-muscle manifestations of muscular dystrophies and their biological basis

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Georgia R. Ditzenberger, NNP, RNC, PhD

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Frank R. Greer, MD, Professor Julie M. Kessel, MD, Associate Professor

Frank R. Greer, MD

Residency: Children’s Hospital Medical Center, Cincinnati, OH

Fellowships: Children’s Hospital Medical Center, Cincinnati, OH

Board certification: Pediatrics, Neotnatal-Perinatal Medicine

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Julie M. Kessel, MD

Residency: Emory University Affiliated Hospitals, Atlanta

Fellowships: Emory University Affiliated Hospitals, Atlanta

Board certification: Pediatrics, Neonatal-Perinatal Medicine

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Pamela J. Kling, MD, Associate Professor Neena D. Shah, MD, Clinical Associate Professor

Pamela J. Kling, MD

Residency: University of Wisconsin Hospital and Clinics

Fellowships:University of Iowa Hospitals and Clinics, Iowa City

Board certification: Pediatrics, Neonatal-Perinatal Medicine

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Neena D. Shah, MD

Residency: St. Joseph’s Hospital, Chicago, IL; University of Illinois Hospital, Chicago, IL

Fellowships:  Vanderbilt University Hospital, TN

Board certification: Pediatrics, Neonatal-Perinatal Medicine

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Recent Publications

Frank R. Greer, MD

SR Daniels, FR Greer. Committee on Nutrition. Lipid screening and cardiovascular health in childhood. Pediatrics. 2008 Jul; 122(1):198-208. PubMed PMID: 18596007

CL Wagner, FR Greer. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. American Academy of Pediatrics, Committee on Nutrition, Section on Breastfeeding. Pediatrics. 2008 Nov; 122(5):1142-1152. PubMed PMID: 18977996

J Bhatia, FR Greer. The use of soy protein-base formulas in infant feeding. American Academy of Pediatrics, Committee on Nutrition, Clinical Report. Pediatrics. 2008 May; 121(5):1062-1068. PubMed PMID: 18450914

FR Greer, SH Sicherer, AW Burks. Effects of early nutritional interventions on the development of atopic disease in infants and children: the role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas. American Academy of Pediatrics, Committee on Nutrition and Section on Allergy and Immunology. Pediatrics. 2008; 121:183-1991.

FR Greer. Time to step up to the plate: adopting the WHO 2006 growth curves for US infants. J Pediatr. 2008 Nov; 153(5):592-594. PubMed PMID: 18940347

FR Greer. Post discharge nutrition: What does the evidence support. In: Ehrenkranz RA, Pointdexter BB. Evidence-Based Nutritional Practices for Very Low Birth Weight Infants. Semin in Perinatol. 2007 Apr; 31:89-95. PubMed PMID: 17462493

FR Greer. Long-term adverse outcomes of low-birth-weight, increased somatic growth rates, and alterations of body composition in the premature infant: Review of the evidence. J Pediatr Gastroenterol Nutr. 2007 Dec; 45 Suppl 3:S147-S151. PubMed PMID: 18185081

FR Greer. 25-Hydroxyvitamin D: functional outcomes in the infant and young child. Am J Clin Nutr. 2008 Aug; 88(2):529S-533S. PubMed PMID: 18689395

FR Greer. Time to step up to the plate: Adopting the WHO 2006 growth curves for US infants. J Pediatr. 2008 Nov; 153(5):592-594. PubMed PMID: 18940347

FR Greer. 25 hydroxyvitamin D: Functional outcomes in infants and young children. Am J Clin Nutr. 2008 Aug; 88(2):529S-533S. PubMed PMID: 18689395

FR Greer. Rickets. EMedicine, 2008.

FR Greer. Post discharge nutrition: What does the evidence support? In Ehrenkranz RA, Pointdexter BB, Evidence-Based Nutritional Practices for Very Low Birth Weight Infants. Semin in Perinatol. 2007; 31(2):89-95. PubMed PMID: 17462493

FR Greer. 25-Hydroxyvitamin D: Functional outcomes in infants and young children. Am J Clin Nutr. 2008 Aug; 88(2):529S-533S. PubMed PMID: 18689395

SR Daniels, FR Greer; Committee on Nutrition. Lipid screening and cardiovascular health in childhood. Pediatrics. 2008 Jul; 122(1):198-208. PubMed PMID: 18596007

J Bhatia, F Greer; American Academy of Pediatrics Committee on Nutrition. Use of soy protein-based formulas in infant feeding. Pediatrics. 2008 May; 121(5):1062-1068. PubMed PMID: 18450914


Julie M. Kessel, MD

JM Kessel, JM Cale, E Verbrick, CR Parker Jr, DP Carlton, IM Bird. Antenatal betamethasone depresses maternal and fetal aldosterone levels. Reprod Sci. 2008 Nov 7. [Epub ahead of print]. PMID: 18997118.


Pamela J. Kling, MD

Kling PJ. Iron supplementation in prematurity: How much is too much? J Pediatr. 2007 Jul; 151(1):3-4. PubMed PMID: 17586179

PJ Kling, A Willeitner, B Dvorak, SE Blohowiak. Milk-borne erythropoietin and iron stimulate erythropoiesis in suckling rats. J Pediatr Gastroent Nutr. 2008; 46:202-207.

PJ Kling. Am I going to die? Acad Med. 2008 Jun; 83(6):567. PubMed PMID: 18520461

SE Blohowiak, ME Chen, KS Repyak, NL Baumann-Blackmore, DP Carlton, MK Georgeiff, TD Crenshaw, PJ Kling. Reticulocyte enrichment and improved sensitivity of zinc protoporphyrin/heme ratios in human cord blood and suckling rats. Pediatr Res. 2008 Jul; 64(1):63-67. PubMed PMID: 18360311

NL Baumann-Blackmore, E Goetz, SE Blohowiak, O Zaka, PJ Kling. Cord blood zinc protoporphyrin/heme ratio in minority neonates at-risk for iron deficiency. J Pediatr. 2008 July; 153(1):133-136. PubMed PMID: 18571551


De-Ann M. Pillers, MD, PhD

B.A. Ghaheri, J.B. Kempton, D.M. Pillers, D.R. Trune. Cochlear cytokine gene expression in murine acute otitis media. Laryngoscope. 2007;117(1):22-29. PubMed PMID: 17202925

T.T. Colaizy, C.D. Morris, J. Lapidus, R.S. Sklar, D.M. Pillers. Detection of Ureaplasma DNA in endotracheal samples is associated with bronchopulomonary dysplasia after adjustment for multiple risk factors. Pediatr Res. 2007 May; 61(5 Pt 1):578-583. PubMed PMID: 17413863

B.A. Ghaheri, J.B. Kempton, D.M. Pillers, D.R. Trune. Cochlear cytokine gene expression in murine chronic otitis media. Otolaryngol Head Neck Surg. 2007 Aug; 137(2):332-337. PubMed PMID: 17666266

C.J. MacArthur, D.M. Pillers, J. Pang, J.M. DeGagne, J.B. Kempton, D.R. Trune. Gram-negative pathogen Klebsiella oxytoca is associated with spontaneous chronic otitis media in toll-like receptor 4-deficient C3H/HeJ mice. Acta Otolaryngol. 2008 Feb; 128(2):132-138. PubMed PMID: 17851949

W.R. Woodward, D. Choi, J. Grose, B. Malmin, S. Hurst, J. Pang, R.G. Weleber, D.M. Pillers. Isoflurane is an effective alternative to ketamine as an anesthetic agent for the mouse electroretinogram. Doc Ophthalmol. 2007 Nov; 115(3):187-201. PubMed PMID: 17885776

G.E. Quinn, V. Dobson, B.V. Davitt, R.J. Hardy, B. Tung, C. Pedroza, W.V. Good, ETROP Cooperative Group (Pillers). Progression of myopia and high myopia in the early treatment for retinopathy of prematurity study: findings to 3 years of age. Ophthalmology. 2008 Jun; 115(6):1058-1064.e.1. PubMed PMID: 18423871

DR Trune, B Kempton, J DeGagne, B Ghaheri, DM Pillers, CJ MacArthur. Tissue remodeling cytokines in the middle and inner ear during acute and chronic otitis media. Annual Midwinter Meeting of the Association for Research in Otolaryngology (ARO). Denver, CO; 2007 Feb.

DM Pillers, B Kempton, B Malmin, J Pang, DR Trune. Abnormal cochlear dystrophin proteins in muscular dystrophy mice. Do they explain the cognitive defects seen in human Duchenne muscular dystrophy? Annual Midwinter Meeting of the Association for Research in Otolaryngology (ARO). Denver, CO; 2007 Feb.

CJ MacArthur, JB Kempton, DM Pillers, JM DeGagne, DR Trune. Bacteriology of chronic otitis media in C3H/HeJ mice. Annual Midwinter Meeting of the Association for Research in Otolaryngology (ARO). Denver, CO; 2007 Feb.

DM Pillers, J Pang, D Trune, X Shi, AF Nuttall. Impact of noise exposure on inflammatory gene expression in the guinea pig and mouse cochleas. Annual Midwinter Meeting of the Association for Research in Otolaryngology (ARO). Denver, CO; 2007 Feb.

DM Pillers, J Pang, D Trune, X Shi, AF Nuttall. Impact of noise exposure on inflammatory gene expression in the guinea pig and mouse cochleas. 13th Annual Blood-Brain Barrier Consortium Meeting. Stevenson, WA; 2007 Mar.

PO Nkadi, J Pang, TA Merritt, DM Pillers. Development of a cell culture-based assay for lung inflammation as a model for chronic lung disease of prematurity. Pediatric Academic Societies Annual Meeting, Toronto, ON. (#751982) Pediatric Research; 2007 May.

HS Hernandez, M Wallisch, DM Pillers, GD Olsen. Functional characterization of Mu opiod receptors: A species comparison of rat and guinea pig as models of the mu opioid receptor. Pediatric Academic Societies Annual Meeting, Toronto, ON. (#752838) Pediatric Research; 2007 May.

DM Pillers, PO Nkadi, J Pang, TA Merritt. KL4 surfactant (SURFAXIN) is associated with a reduction in bone morphogenetic protein (BMP) gene expression in a cell culture-based assay of lung inflammation. Poster presentation at the Pediatric Academic Societies Annual Meeting, Toronto, ON. (#750555) Pediatric Research; 2007 May.

DM Pillers, B Malmin, JT den Dunnen, DR Trune. Upregulation of retinal dystrophin Dp260 transcription by methylprednisolone is mediated by glucocorticoid receptor. Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO). Fort Lauderdale; 2007 May; (Program Number 3772).

AL Nuttall, I Omelchenko, D Trune, J Pang, DM Pillers. Cochlear cytokine expression in the ear following noise exposure: The influence of nitrite treatment. 8th World Congress for Microcirculation Meeting. Milwaukee, Wisconsin; 2007 August 15-19.

DM Pillers, PO Nkadi, J Pang, TA Merritt. Development of a cell culture-based assay for lung inflammation as a model for chronic lung disease of prematurity. Poster presentation at the 2007 AAP NCE Perinatal Section Annual Meeting. San Francisco, CA; 2007 Oct.

D Trune, J Pang, B Kempton, C MacArthur, DM Pillers. Correlation of middle and inner ear cytokine gene expression in mouse otitis media models suggest inflammatory factors contribute to sensorineural hearing loss. Annual Midwinter Meeting of the Association for Research in Otolaryngology (ARO). Phoenix, AZ; 2008 Feb.

DM Pillers, J Pang, JB Kempton, CJ MacArthur, DR Trune. Inner ear inflammatory gene expression during acute and chronic otitis media in the mouse. Pediatric Academic Societies Annual Meeting. Honolulu, Hawaii; (#751633) Pediatric Research; 2008 May.

DR Trune, DM Pillers, JB Kempton, CJ MacArthur. Steroid treatments protect the mouse inner ear during chronic otitis media. Pediatric Academic Societies Annual Meeting. Honolulu, Hawaii; (#752670) Pediatric Research; 2008 May.

DM Pillers, J Pang, DR Trune. Enhanced retinal dystrophin Dp260 upregulation by glucocorticoid in MRL autoimmune mouse. Poster presentation at the Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO). Fort Lauderdale; 2008 May.

Grant Support

De-Ann M. Pillers, MD, PhD

  • NIH 5R01 DC005593 (09/01/08-08/31/12)
    "Steroid Responsive Mechanisms in the Ear"
    Role: Collaborating Co-Investigator
  • NIH R21 DC007443 (07/01/06-06/30/09)
    "Otitis Media Impact on the Inner Ear"
    Role: Consulting Co-Investigator
  • NIH SBIR Phase II R44 AI065000 (06/15/07-05/31/10)
    "Bacterial-Induced Sepsis:  A New Treatment Strategy"
    Role: Consultant
  • NIH 5R21 A1070589 (12/01/07-08/31/09)
    "Limiting Inflammation in Bacterial Meningitis by Targeting Host Immune Pathways"
    Role: Consultant
  • NIH 5R01 DC000105 (12/30/08-01/31/13)
    "Control of Inner Ear Microcirculation"
    Role: Consulting Co-Investigator
  • NIH 5R01HL049210 (07/01/93-05/31/12)
    "Endothelium-Derived Vasodilators in Pregnancy"
    Role: Co-Investigator