Division Highlights - Endocrinology & Diabetes

2007 - 2008 Highlights

David Allen, MD, and Michael MacDonald, MD, successfully apply for the divison’s first T-32 training grant

Aaron Carrel, MD, develops a new medical student course, “Prevention of Overweight and Obesity”

Ellen Connor, MD, develops a new resident rotation on obesity

Overview

The Division of Endocrinology & Diabetes maintains excellence in clinical care, education, and research through collaborations within an established interdisciplinary team.

The division operates four multidisciplinary clinics: the Pediatric Diabetes Clinic, the Pediatric Endocrinology Clinic, the Pediatric Polycystic Ovarian Syndrome Clinic, and the Pediatric Fitness Clinic.

Each clinic relies on the combined talents of board-certified pediatric endocrinologists, doctors-in-training, certified diabetes educators, pediatric nurse practitioners, nutritionists, social workers, and psychologists. These caregivers blend understanding, sensitivity, and concern for each child with state-of-the-art medical care.

The division also conducts clinical, transitional, and basic research in areas related to diabetes, endocrinology, and metabolic disorders. Our research aims to improve the health and quality of life of children with diabetes and endocrine disorders.

Faculty

Division Chief: Michael J. MacDonald, MD, Professor David B. Allen, MD, Professor

Michael J. MacDonald, MD

 

Residency: Massachusetts General Hospital

Fellowships: Children's Hospital Medical Center, Boston; Elliott P. Joslin Research Laboratory, Harvard Medical School, Boston

Board certification: Pediatrics, Pediatric Endocrinology

Clinical interests: children with diabetes; research interests in pediatric diabetes and the biochemistry of the pancreatic insulin-producing cell

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David B. Allen, MD

Residency: University of Wisconsin Hospital and Clinics

Fellowships: University of Wisconsin Hospital and Clinics

Board certification: Pediatrics, Pediatric Endocrinology

Clinical interests: childhood growth and development, growth hormone treatment, prevention of childhood obesity and diabetes, and newborn screening for endocrine disorders

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M. Tracy Bekx, MD, Assistant Professor Aaron L. Carrel, MD, Associate Professor

M. Tracy Bekx, MD

Residency: Columbus Children's Hospital, OH

Fellowships: University of Wisconsin Hospital and Clinics

Board certification: Pediatrics, Pediatric Endocrinology

Clinical interests: diabetes, the endocrine aspects of Down Syndrome, and Polycystic Ovarian Syndrome

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Aaron L. Carrel, MD

Residency: University of Wisconsin Hospital and Clinics

Fellowships: University of Wisconsin Hospital and Clinics

Board certification: Pediatrics, Pediatric Endocrinology

Clinical interests: childhood growth and weight disturbances, and Prader-Willi Syndrome

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Ellen L. Connor, MD, Associate Professor Ei Terasawa, PhD, Professor

Ellen L. Connor, MD

Residency: University Hospital, Shreveport, LA

Fellowships: University of Florida, Gainesville

Board certification: Pediatric Endocrinology

Clinical interests: growth and autoimmune thyroid and adrenal diseases, and Polycystic Ovarian Syndrome

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Ei Terasawa, PhD

Interests: reproductive physiology

Gordon A. Tuffli, MD, Clinical Professor Emeritus Todd S. Varness, MD, Assistant Professor

Gordon A. Tuffli, MD

 

Todd S. Varness, MD

Residency: University of Wisconsin Hospital and Clinics

Fellowships: University of Wisconsin Hospital and Clinics

Board certification: Pediatrics

Clinical interests: bioethics and childhood obesity

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Recent Publications

David B. Allen, MD

Allen DB (consensus conference presenter and workshop member). Consensus guidelines for the diagnosis and treatment of children with idiopathic short stature: a summary statement of the Growth Hormone Research Society in association with the Lawson Wilkins Pediatric Endocrine Society and the European Society for Pediatric Endocrinology. Cohen P, Rogol A, Deal C, et al. J Clin Endocrinol Metab 93(11): 4210-4217;2008. PubMed PMID: 18782877.

McVean JJF, Allen DB. Poor glycemic control predicts occurrence and progression of microalbuminuria in children with type 1 diabetes.(Invited commentary). Journal of Pediatrics, September 2008; 442-443.


M. Tracy Bekx, MD

First author: abstract: “Characteristics of adolescents presenting to a multidisciplinary clinic for polycystic ovarian syndrome” accepted for poster presentation at the Pediatric Academic Society National Meeting (Toronto, Canada) and the National Endocrine Society Meeting (Toronto, Canada 2007).


Aaron L. Carrel, MD

Haqq A, Carrel AL. Ghrelin concentrations in Prader-Willi syndrome (PWS) infants and children: Changes during development. Clinical Endocrinology 2008, 69: 911-920. PubMed PMID: 18710462.

Carrel AL, Allen DB. Interpreting central adrenal insufficiency in Prader-Willi syndrome. J Clin Endo Metab June 22 2008.


Ellen L. Connor, MD

Bekx MT, Connor EL and Allen DB. Clinical Characteristics of Adolescents with PCOS. Submitted to J of Adol and Ped Gynecology, 2008.


Michael J. MacDonald, MD

MacDonald, M.J., Dobrzyn, A., Ntambi, J., Stoker, S.W. The role of rapid lipogenesis in insulin secretion: Insulin secretagogues acutely alter lipid composition of INS-1 832/13 cells. Arch. Biochem. Biophys. 470:153-162, 2008. PubMed PMID: 18082128.

MacDonald, M.J., Longacre, M.J., Stoker, S.W., Brown, L.J., Hasan, N.M., Kendrick, M.A. Acetoacetate and b-hydroxybutyrate in combination with other metabolites release insulin from INS-1 cells and provide clues about pathways in insulin secretion. Am. J. Physiol. Cell. Physiol. 294:C442-C450, 2008.

Edghill, E.L., Flanagan, S.E., Patch, A.M., Boustred, C., Parrish, A., Shields, B., Shepherd, M.H., Hussain, K., Kapoor, R.R., Malecki, M., MacDonald, M.J., Stoy, J., Steiner, D.F., Philipson, L.H., Bell, G.I., The Neonatal Diabetes International Collaborative Group, Hattersley, A.T., Ellard, S. Insulin mutation screening in 1044 patients with diabetes: Mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood. Diabetes 47:1034-1042, 2008.

MacDonald, M.J., Hasan, N.M., Longacre, M.J. Studies with leucine, b-hydroxybutyrate and ATP citrate lyase-deficient cells support the acetoacetate pathway of insulin secretion. Biochim. Biophys. Acta. 1780:966-972, 2008. PubMed PMID: 18439432.

MacDonald, M.J., Stoker, S.W., Hasan, N.M. Anaplerosis from glucose, a-ketoisocaproate, and pyruvate in pancreatic islets, INS-1 cells and liver mitochondria. Mol. Cell. Biochem. 313:195-202, 2008. PubMed PMID: 18414997.

McVean, J.J., Eickhoff, J.C., MacDonald, M.J. Prevalence of early microalbuminuria in children with Type 1 diabetes mellitus. J. Pediatr. Endocrinol. Metab. 21:469-471, 2008.

Fallon, M.J., MacDonald, M.J. Beta cell a-ketoglutarate hydroxylases may acutely participate in insulin secretion. Metabolism 57:1148-1154, 2008. PubMed PMID: 18640395.

Hasan, N.M., Longacre, M.J., Stoker, S.W., Boonsaen, T., Jitrapakdee, S., Kendrick, M.A., Wallace, J.C., MacDonald, M.J. Impaired anaplerosis and insulin secretion in insulinoma cells caused by siRNA-mediated suppression of pyruvate carboxylase. J. Biol. Chem. 283:28048-28059, 2008. PubMed PMID: 18697738.

Grant Support

David B. Allen, MD

  • NIH T32 Fellowship Training program (2008-2013)
    “Prevention of Childhood Type 2 Diabetes and Other Obesity-Related Diseases”
    Supports two postdoctoral fellows per year for five years.
    Role: Co-PI/Program Director
  • Thrasher Award (2007-2008)
    “Validation of PACER Test as an Indicator of Fitness and Diabetes Risk in Middle-School Children”
    Role: Faculty Research Mentor for Todd Varness, MD, MPH
  • Endocrine Fellowship Foundation Award (2008-2009)
    “Fetal Programming of PCOS by Androgen Excess: A Developmental Etiology for Changes in Islet Cell Mass and Subsequent Manifestation of Decreased Insulin Secretion”
    Role: PI and Faculty Research Mentor for Lindsey Nicol, MD
  • Group Health Cooperative of Wisconsin (2005-2008)
    “Validation of Assessment Tools for Fitness and Insulin Sensitivity in Wisconsin Middle-School Children”
    Role: PI
  • “Healthiest Wisconsin 2010: A Partnership Plan to Improve the Health of the Public” (2007-2010)
    “The Wisconsin Partnership for Improved Fitness in Children (WPIFC)”
    Role: Faculty Collaborator

Aaron L. Carrel, MD

  • NIH/NIDDK T32 DK077586 (7/1/08–6/30/11)
    Training grant for pediatric endocrinology training in insulin resistance.
    Role: Associate Director
  • DOE Q215F070128 / Department of Education Physical Education Programming (PEP) Grant (9/1/07-8/30/10)
    “YMCA Kids Fit Assessment”
    Evaluates the effect of an after-school program on cardiovascular fitness in elementary school children.
    Role: PI (Academic Partner)
  • Wisconsin Partnership Program Implementation Grant (6/1/08-5/31/11)
    “Got Dirt?”
    A school and community gardening program to improve fruit and vegetable intake through school children throughout Wisconsin.
    Role: PI
  • Wisconsin Partnership Program Implementation Grant (6/1/07-5/31/10)
    “Wisconsin Partnership for Childhood Fitness”
    Establishes a statewide program for evaluating and tracking fitness in middle-school children throughout Wisconsin.
    Role: PI
  • Wisconsin Partnership Program Planning Grant (9/1/06-8/31/08)
    “Fit Kids, Fit Cities”
    Promotes physical activities in Wisconsin cities.
    Role: PI (Academic partner)
  • National Institutes of Health Grant T32 DK077586 (7/1/08 – 6/30/13)
    “Childhood Diabetes Clinical and Molecular Research Training (CDCMRT) Program”
    Role: PI

Todd S. Varness, MD

  • University of Wisconsin Institute for Clinical and Translational Research Type 2 Translational Research Grant (2008)
    “Development of a Tool for Diabetes Risk Assessment in Children”
    Develop and validate a cost-effective and feasible field-based tool for diabetes risk assessment in children.
    Role: PI