Division Highlights - Allergy, Immunology & Rheumatology

2007 - 2008 Highlights

Top division for extramural funding in 2007 and 2008

James Gern, MD’s research finds rhinovirus to be a major promoter of asthma

Anna Huttenlocher, MD, receives Burroughs Wellcome Foundation’s Translational Award and UW’s Romnes Faculty Research Award

Judith Smith, MD, PhD, receives KL2 award from UW’s ICTR

Overview

The Division of Allergy, Immunology, and Rheumatology provides outstanding care for children with allergic, immunologic, and rheumatologic diseases.

Our integrated training program is designed to improve patient care and develop future clinicians and academicians.

Our research aims to:

  • Identify the connections between viral respiratory infections and asthma;
  • Evaluate T regulatory cell function in atopic diseases and asthma;
  • Understand how inflammatory cells migrate to sites of tissue inflammation;
  • Evaluate asthma therapies by participating in clinical research networks; and
  • Establish how gene by environment interactions participate in the expression of allergic diseases and asthma.

Faculty

Division Chief: Robert F. Lemanske, Jr., MD, Professor Marcus Cohen, MD, Clinical Professor

Robert F. Lemanske, MD

 

Residency: University of Wisconsin Hospital and Clinics

Fellowships: Allergy and Immunology, University of Wisconsin Hospital and Clinics; National Institute of Allergy and Infectious Diseases

Board certification: Pediatrics, Allergy & Immunology

Clinical interests: pathophysiology and treatment of asthma, including mechanisms underlying pulmonary late phase reactions, virus-induced airway dysfunction, and asthma inception in infants and young children

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Marcus Cohen, MD

Residency: University of California, San Francisco

Fellowships: University of Wisconsin Hospital and Clinics

Board certification: Pediatrics, Allergy & Immunology

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James E. Gern, MD, Professor Christopher T. Healy, MD, Clinical Assistant Professor

James E. Gern, MD

Residency: State University of New York Upstate Medical Center, Syracuse, NY and Tufts University School of Medicine, Boston, MA

Fellowships: Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, MD

Board certification: Pediatrics, Allergy & Immunology

Clinical interests: how common cold infections affect the onset and activity of asthma, and contributing factors to asthma in urban environments

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Christopher T. Healy, MD

Residency: Medical College of Wisconsin, Milwaukee

Fellowships: Medical College of Wisconsin, Milwaukee

Board certification: Pediatrics, Allergy & Immunology

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Anna Huttenlocher, MD, Professor Mark H. Moss, MD, Associate Professor

Anna Huttenlocher, MD

Residency: University of California, San Francisco, CA

Fellowships: Pediatric Immunology & Rheumatology, University of California, San Francisco

Board certification: Pediatrics, Pediatric Rheumatology

Clinical interests: autoinflammatory disease

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Mark H. Moss, MD

Residency: University of Wisconsin Hospital and Clinics

Fellowships: University of Wisconsin Hospital and Clinics

Board certification: Pediatrics, Allergy & Immunology

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Michael W. Ritter, MD, Associate Professor Christine M. Seroogy, MD, Assistant Professor

Michael W. Ritter, MD

Residency: University of Wisconsin Hospital and Clinics

Fellowships: University of Wisconsin Hospital and Clinics

Board certification: Pediatrics, Allergy & Immunology

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Christine M. Seroogy, MD

Residency: Harvard University, Children’s Hospital, Boston, MA

Fellowships: Allergy and Immunology, University of California, San Francisco, CA

Board certification: Pediatrics, Allergy & Immunology

Clinical interests: understanding the immunologic contexts that lead to CD4+ T cell unresponsiveness or anergy. She has a special interest in regulatory T cells in the initiation, perpetuation and regulation of allergic inflammation

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Judith A. Smith, MD, PhD, Assistant Professor of Pediatrics  

Judith A. Smith, MD, PhD

Residency: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

Fellowships: Rheumatology, Cincinnati Children’s Hospital Medical Center

Board certification: Pediatrics and Rheumatology

Clinical interests: Regulation of Type I IFN production by macrophages

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Past Fellows

Name Completed Fellowship Current Employment
Jeremy Bufford, MD 2007 Associate Physician, Marshfield Clinic, Stevens Point, WI
Samuel Friedlander, MD 2007 Clinical Instructor, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH
Sujani Kakumanu, MD 2008 Staff, Allergy/Immunology Department, VA Hospital, Madison, WI
Anne Marie Singh, MD 2008 Assistant Professor, Northwestern University, Chicago, IL
Steve McEldowney, MD 2008 Private practice, Charlotte, NC

Recent Publications

James E. Gern, MD

Singh AM, Moore PE, Gern JE, Lemanske RFJr, and Hartert TV. Infant bronchiolitis to childhood asthma: a call for studies of gene-viral interactions in asthma causation. Am J Respir Crit Care Med 175:108-119, 2007. PubMed PMID: 17053206.

Gern JE, Mosser AG, Swenson CA, Rennie P, England RJ, Schaffer J, Mizoguchi H. Inhibition of rhinovirus replication in vitro and in vivo by acid-buffered saline. J Infect Dis 195(8):1137-43, 2007. PMID: 17357049.

Thompson EE, Pan L, Ostrovnaya I, Weiss LA, Gern JE, Lemanske RF Jr, Nicolae DL, Ober C. ITGB3 genotype influences asthma and allergy phenotypes in the first six years of life. J Allergy Clin Immunol 119:1423-9, 2007. PubMed PMID: 17556058.

Jartti T, Burmeister K, , Seroogy C, Jennens-Clough ML Tisler C, Salazar L, DaSilva D, Evans M, Vrtis R, Wallace PK, Ruiz-Perez B, Gangnon R, Lemanske RF Jr, and Gern JE. Association between CD4+CD25high T cells and atopy in children. J Allergy Clin Immunol 120:177-183, 2007. PubMed PMID: 17433828.

Gern JE and Busse WW. Modernization of the medical Sherlock Holmes (editorial). J Infect Dis 196:810-811, 2007. PubMed PMID: 17703409.

Lee WM, Grindle K, Pappas T, Marshall DJ, Moser MJ, Beaty EL, Shult PA, Prudent JR, Gern JE. High-throughput, sensitive, and accurate multiplex PCR-microsphere flow cytometry system for large-scale comprehensive detection of respiratory viruses. J Clin Microbiol. 45(8):2626-34, 2007. PubMed PMID: 17537928.

Tan Z, Randall G, Fan J, Camoretti-Mercado B, Brockman-Schneider R, Pan L, Solway J, Gern JE, Lemanske RF, Nicolae D, Ober C Allele-specific targeting of microRNAs to HLA-G and risk for asthma. Am J Hum Genet, 81:829-34, 2007. PubMed PMID: 17847008.

Bufford J and Gern JE. Early exposure to pets: good or bad? Current Allergy and Asthma Reports, 7:375-82, 2007. PubMed PMID: 17697647.

Lee W-M, Kiesner C, Pappas T, Lee I, Grindle K, Jartti T, Jakiela B, Lemanske RF Jr, Shult PA and Gern JE. A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants. PLoS ONE 2(10): e966. doi:10.1371/journal.pone.0000966, 2007. PubMed PMID: 17912345.

Marshall DJ, Reisdorf E, Harms G, Beaty E, Moser MJ, Lee WM, Gern JE, Nolte FS, Shult P, Prodent JR. Evaluation of a Multiplexed PCR Assay for Detection of Respiratory Viral Pathogens in a Public Health Laboratory Setting. J Clin Microbiol 45:3875-3882, 2007. PubMed PMID: 17928425.

Barrett B, Rakel D, Chewning B, Marchand L, Rabago D, Brown R, Scheder J, Schmidt R, Gern JE, Phyto KBD, Thomas G, Barlow S. Rationale and methods for a trial assessing placebo, echinacea, and doctor patient interaction in common cold. Explore (NY) 3:561-72, 2007. PubMed PMID: 18005908.

Gern JE, Stone CK, Nakano M, Muchmore DB, de la Peña A, Park S, Suri A, Tibaldi F, Soon D, Busse WW. Effect of upper respiratory tract infection on AIR® inhaled insulin pharmacokinetics and glucodynamics in healthy subjects. Clin Pharmacol Therapeutics 83:307-311, 2008.

Sullivan Dillie KT, Tisler CJ, DaSilva DF, Pappas TE, Roberg KA, Carlson-Dakes KT, Evans MD, Rosenthal LA, Gangnon RE, Gern JE, Lemanske RF Jr. The influence of processing factors and non-atopy related maternal and neonate characteristics on yield and cytokine responses of cord blood mononuclear cells Clin Exp Allergy 38:298-304, 2008. PubMed PMID: 18070154.

Ober C, Tan Z, Sun Y, Possick JD, Pan L, Nicolae R, Radford S, Parry RP, Heinzmann A, Deichmann KA, Lester LA, Gern JE, Lemanske RF Jr, Nicolae DL, Elias JA, and Chupp GL. Variation in the CHI3L1 gene influences serum YKL-40 levels, asthma risk, and lung function. N Engl J Med 358:1682-91, 2008. PubMed PMID: 18403759.

Busch MG, Bateman AC, Landolt GA, Karasin AI, Brockman-Schneider RA, Gern JE, Suresh M, and Olsen CW. Identification of amino acids in the HA of H3 influenza viruses that determine infectivity levels in primary swine respiratory epithelial cells. Virus Research 133:269-279, 2008. PubMed PMID: 18329747.

Jakiela B, Brockman-Schneider R, Amineva S, Lee W-M, Gern JE. Basal cells of differentiated bronchial epithelium are more susceptible to rhinovirus infection. Am J Resp Cell Mol Biol 38:517-23, 2008. PubMed PMID: 18063839.

Gern JE. Viral respiratory infection and the link to asthma. Ped Infect Dis J 27:S71-S74, 2008. PMID: 18820588.

Bufford JD, Reardon CL, Li Z, Roberg KA, Tisler C, Anderson E, DaSilva D, Eggleston PA, Liu A, Milton D, Alwis U, Gangnon R, Lemanske RF Jr, Gern JE. Effects of dog exposure in early childhood on immune development and atopic diseases. Clinical Exp Allergy 2008;38:1635-43. PubMed PMID: 18702654.

Jartti T, Lee WM, Pappas T, Evans M, Lemanske RF Jr, Gern JE. Serial viral infections in infants with recurrent respiratory illnesses. Eur Resp J 2008;32(2):314-20. PubMed PMID: 18448489.

Jackson DJ, Evans MD, Anderson EL, Salazar L, DaSilva DF, Pappas TE, Roberg KA, Tisler CJ, Gangnon R, Gern JE, Lemanske RF Jr. Wheezing rhinovirus illnesses during early childhood predict the subsequent development of asthma. Am J Resp Crit Care Med 178:667-672, 2008. PubMed PMID: 18565953.

Papadopoulos NG, Borres M, Gern J, Nieto A. New visions in respiratory allergy (asthma and allergic rhinitis): An iPAC summary and future trends. Pediatr Allergy Immunol 2008:19(suppl 19):51-59. PubMed PMID: 18665963.

Sorkness RL, Gonzalez-Fernandez G, Billmeyer EE, Evans MD, Gern JE, Jarjour NN. The asthma index: a continuous variable to characterize exacerbations of asthma. J Allergy Clin Immunol 2008;122:838-840. PubMed PMID: 18774167.

Brockman-Schneider RA, Amineva S, Bulat MV, and Gern JE. Serial culture of murine primary airway epithelial cells and ex vivo replication of human rhinoviruses. J Immunol Methods 2008;339:264-6. PubMed PMID: 18824171.

Sly PD, Boner AL, Bjorksten B, Bush A, Custovic A, Eigenmann PA, Gern JE, Gerritsen J, Hamelmann E, Helms P, Lemanske RF, Martinez F, Pedersen S, Renz H, von Mutius E, Wahn U, Holt PG. Early identification of children likely to develop persistent asthma: atopy is an integral component of the high risk phenotype. Lancet 2008; 372(9643):1100-6. PubMed PMID: 18805338.


Anna Huttenlocher, MD

Huttenlocher, A and Horwitz, AF. (2007) Wound Healing with electric potential, New England Journal of Medicine 356:303-4. PubMed PMID: 17229960.

Nuzzi, P, Lokuta, M, and Huttenlocher, A. (2007) Analysis of neutrophil chemotaxis. Methods in Molecular Biology, 370:23-36. PubMed PMID: 17416985.

Nuzzi, PA, Senetar, MA and Huttenlocher, A. (2007) Asymmetric localization of calpain 2 during neutrophil chemotaxis, Molecular Biology of the Cell 18:795-805. PubMed PMID: 17192410.

Cortesio, C, Chan, K, and Huttenlocher, A. (2007) Integrins in cell migration, Methods in Enzymology 426:47-67. PubMed PMID: 17697879.

Doan, AT and Huttenlocher, A. (2007) RACK1 regulates Src activity and modulates paxillin dynamics during cell migration. Experimental Cell Research 313 (12):2667-79. PubMed PMID: 17574549.

Clay, H, David, JM, Beery, D, Huttenlocher, A, Lyons, S and Ramakrishnan, L. (2007) Dichotomous role of the macrophage in early tuberculosis. Cell Host Microbe 12:29-39. PubMed PMID: 18005715.

Mathias, JR, Dodd, ME, Walters KB, Rhodes, J, Kanki, J, Look, AT and Huttenlocher, A. (2007) Live imaging of chronic inflammation caused by mutation of zebrafish HAI-1, Journal of Cell Science 120:3372-83. PubMed PMID: 17881499.

Lokuta, MA, Senetar, MA, Nuzzi, PA, Bennin, DA, Chan KT, Ott, VL and Huttenlocher, A. (2007) Type Ig PIPK is a novel uropod component that regulates rear retraction during neutrophil chemotaxis, Molecular Biology of the Cell 18:5069-80. PubMed PMID: 17928408.

Cortesio, CL, Chan, KT, Perrin, BJ, Burton, N, Zhang, S, Zhang, Z and Huttenlocher, A. (2008) Regulation of invadopodia formation and dynamics in breast cancer cell by a signaling pathway that involves calpain 2, PTP1B and Src, Journal of Cell Biology 180:957-71. PubMed PMID: 18332219.

Lokuta, MA, Nuzzi, PA and Huttenlocher, A. (2007) Analysis of neutrophil polarization and chemotaxis. Methods Molecular Biology 412:211-29. PubMed PMID: 18453114.

Huttenlocher, A and Poznansky, M. (2008) Reverse leukocyte migration can be attractive or repulsive. Trends in Cell Biology 18:298-306. PubMed PMID: 18468440.

Wernimont, SA, Cortesio, CL, Simonson, WT and Huttenlocher, A. (2008) Adhesions ring: a structural comparison between podosomes and the immune synapse, European Journal of Cell Biology, 87:507-15. PubMed PMID: 18343530.

Cooper, KM, Bennin, DA and Huttenlocher, A. (2008) The PCH family member PSTPIP1 targets to the leukocyte uropod and regulates directed cell migration. Molecular Biology of the Cell 19:3180-91. PubMed PMID: 18480402.

Abhyankar VV, Toepke MW, Cortesio CL, Lokuta MA, Huttenlocher A and Beebe DJ. (2008) A platform for assessing chemotactic migration within a spatiotemporally defined 3D microenvironment. Lab Chip 8:1507. PubMed PMID: 18818806.

Wang X, Chen X, Rodenkirch L, Simonson W, Wernimont S, Ndonye RM, Veerapen N, Gibson D, Howell AR, Besra GS, Painter GF, Huttenlocher A, Gumperz JE. (2008) Natural killer T-cell autoreactivity leads to a specialized activation state. Blood 112:4128-38. PubMed PMID: 18779390.

Ferguson PJ, Lokuta MA, El-Shanti HI, Muhle L, Bing X and Huttenlocher A. (2008) Neutrophil dysfunction in a family with a SAPHO syndrome-like phenotype. Arthritis and Rheumatism 58:3264-9. PubMed PMID: 18821685.

Walters KB, Dodd ME, Mathias JR, Gallagher AJ, Bennin DA, Rhodes J, Kanki JP, Look AT, Grinblat Y and Huttenlocher A. (2008) Muscle degeneration and leukocyte infiltration caused by mutation of zebrafish fad24. Developmental Dynamics 238:86-99. PubMed PMID: 19097072.

Undyala VV, Dembo M, Cembrola K, Perrin BJ, Huttenlocher A, Elce JS, Greer PA, Wang YL, Beningo KA. (2008). The calpain small subunit regulates cell-substrate mechanical interactions during fibroblast migration. J Cell Sci. 2008 Nov 1;121(Pt 21):3581-8. PubMed PMID: 18840650.


Robert F. Lemanske, Jr., MD

Deykin A, Wechsler ME, Boushey HA, Chinchilli VM, Kunselman SJ, Craig TJ, Dimango E, Fahy JV, Kraft M, Leone F, Lazarus SC, Lemanske RF, Martin RJ, Pesola GR, Peters SP, Sorkess CA, Szefler SJ, Israel E. Combination Therapy with a Long-acting Beta-Agonist and Leukotriene Antagonist in Moderate Asthma. Am J Respir Crit Care Med. 175 (3):228-234, 2007. PubMed PMID: 16973987.

Sorkness RL, Herricks KM, Szakaly RJ, Lemanske RF Jr, Rosenthal LA, Altered allergen induced eosinophil trafficking and physiological dysfunction in airways with pre-existing virus induced injury. Am J Physiol Lung Cell Mol Physiol 292:L85-L91, 2007. PubMed PMID: 16905639.

Denlinger LC, Sorkness CA, Chinchilli VM, Lemanske RF Jr. Guideline-defining asthma clinical trials of the National Heart, Lung and Blood Institute’s Asthma Clinical Research Network and Childhood Asthma Research and Education Network. J Allergy Clin Immunol 119:3-11, 2007. PubMed PMID: 17141853.

Sorkness CA, Lemanske RF Jr, Mauger DT, Boehmer SJ, Chinchilli VM, Martinez FD, Strunk RC, Szefler SJ, Zeiger RS, Bacharier LB, Bloomberg GR, Covar RA, Guilbert TW, Heldt G, Larsen G, Mellon MH, Morgan WJ, Moss MH, Spahn JD, Taussig LM. Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: The Pediatric Asthma Controller Trial. J Allergy Clin Immunol 119:64-72, 2007. PubMed PMID: 17140647.

Singh AM, Moore PE, Gern JE, Lemanske RF Jr, Hartert TV. Bronciolitis to asthma: a review and call for studies of gene-virus interactions in asthma causation. Am J Respir Crit Care Med 175:108-119, 2007. PubMed PMID: 17053206.

Martin RJ, Szefler SJ, King TS, Kraft M, Boushey HA, Chinchilli VM et al. The predicting response to inhaled corticosteroid efficacy (PRICE) trial. J Allergy Clin Immunol 119:73-80, 2007. PubMed PMID: 17208587.

Lazarus SC, Chinchilli VM, Rolling NJ, Boushey HA, Cherniack R, Craig TJ, Deykin A, DiMango E, Fish JE, Ford JG, Israel E, Kiley J, Kraft M, Lemanske RF Jr, Leone FT, Martin RJ, Resola GR, Peters SP, Sorkness CA, Szefler SJ, Wechsler ME, Fahy JV. Smoking Affects Response to Inhaled Corticosteroids or Leukotriene Receptor Antagonists in Asthma. Am J Respir Crit Care Med 175(8): 783-790, 2007. PubMed PMID: 17204725.

Thompson EE, Pan L, Ostrovnaya I, Weiss LA, Gern JE, Lemanske RF Jr, Nicolae DL, Ober C. Integrin β3 genotype influences asthma and allergy phenotypes in the first 6 years of life. J Allergy Clin Immunol 119(6):1423-1429, 2007. PubMed PMID: 17556058.

Tan Z, Randall G, Fan J, Camoretti-Mercado B, Brockman-Schneider R, Pan L, Solway J, Gern J, Lemanske RF Jr, Nicolae D, Ober C. Allele-Specific Targeting of microRNAs to HLA-G and Risk of Asthma. Am J Hum Genet 81(4):829-834, 2007. PubMed PMID: 17847008.

Lee W-M, Kiesner C, Pappas T, Lee I, Grindle K, Jartti T, Jakiela B, Lemanske RF Jr, Shult PA and Gern JE. A diverse group of previously unrecognized human rhinoviruses are common causes of respiratory illnesses in infants. PLoS ONE 2(10): e966. doi:10.1371/journal.pone.0000966, 2007. PubMed PMID: 17912345.

Yawn BP, Enright PL, Lemanske RF Jr, Israel E, Pace W, Wollan P, Boushey H. Spirometry can be done in family physicians’ offices and alters clinical decisions in management of asthma and COPD. Chest 132:1162-1168, 2007. PubMed PMID: 17550939.

Busse WW, Lemanske RF Jr. Expert Panel Report 3: Moving forward to improve asthma care. J Allergy Clin Immunol 120(5):1012-1014, 2007. PubMed PMID: 17983868.

Lemanske RF Jr, Busse WW. Lesson from human experimental rhinovirus infection in combination with allergen exposure. Part IV, Chapter 15 In Exacerbations of Asthma. Johnston SL, O’Byrne PM, eds. Informa, Abingdon, Oxon, United Kingdom, 2007. pp. 265-274.

Uekert SJ, Lemanske RF Jr, Busse WW. Treatment and prevention of asthma exacerbations: how good are inhaled corticosteroids alone at preventing asthma exacerbations? Part V, Chapter 17 In: Exacerbations of Asthma. Johnston SL, O’Byrne PM, eds. Informa, Abingdon, Oxon, United Kingdom, 2007. pp. 285-296.

Sullivan Dillie KT, Tisler CJ, DaSilva DF, Pappas TE, Roberg KA, Carlson-Dakes KT, Evans MD, Rosenthal LA, Gangnon RE, Gern JE, Lemanske RF Jr. The influence of processing factors and non-atopy-related maternal and neonate characteristics on yield and cytokine responses of cord blood mononuclear cells. Clin Exp Allergy 38:298-304, 2008. PubMed PMID: 18070154.

Ober C, Tan Z, Sun Y, Possick J, Pan L, Nicolae R, Radford S, Parry RR, Heinzmann A, Deichmann K, Lester L, Gern JE, Lemanske RF Jr, Nicolae DL, Elias JA, Chupp GL. Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. N Engl J Med 358 (16):1682-1691, 2008. PubMed PMID: 18403759.

Jackson DJ, Gangnon RE, Evans MD, Roberg KA, Anderson EL, Pappas TE, Printz MC, Lee WM, Shult PA, Reisdorf E, Carlson-Dakes KT, Salazar LP, DaSilva DF, Tisler CJ, Gern JE, Lemanske RF. Wheezing rhinovirus illnesses in early life predict asthma development in high risk children. Am J Respir Crit Care Med 178 (7):667-672, 2008. PubMed PMID: 18565953.

Bufford JD, Reardon CL, Li Z, Roberg KA, DaSilva D, Eggleston PA, Liu AH, Milton D, Alwis U, Gangnon R, Lemanske RF Jr, Gern JE. Effects of dog ownership in early childhood on immune development and atopic diseases. Clin Exp Allergy, 38 (10):1635-1643, 2008. PubMed PMID: 18702654.

Jartti T, Lee WM, Pappas T, Evans M, Lemanske RF Jr, Gern JE. Serial viral infections in infants with recurrent respiratory illnesses. Eur Respir J 32 (2): 314-320, 2008. PubMed PMID: 18448489.

Craig TJ, King TS, Lemanske RF Jr, Weshsler ME, Icitovic N, Zimmerman RR, Wasserman S. Aeroallergen sensitization correlates with PC20 and exhaled nitric oxide in subjects with mild-to moderate asthma. J Allergy Clin Immunol 121 (3):671-677, 2008. PubMed PMID: 18234311.

Sly PD, Boner AL, Bjorksten B, Bush A, Custovic A, Eigenmann PA, Gern JE, Gerritsen J, Hamelmann E, Helms PJ, Lemanske RF, Martinez F, Pedersen S, Renz H, Sampson H, von Mutius E, Wahn U, Holt PG. Early identification of atopy in the prediction of persistent asthma in children. Lancet 372 (9643):1100-1106, 2008. PubMed PMID: 18805338.

Walter MJ, Castro M, Kunselman SJ, Chinchilli VM, Reno M, Ramkumar TP, Avila PC, Boushey HA, Ameredes BT, Bleecker ER, Calhoun WJ, Cherniack RM, Craig TJ, Denlinger LC, Israel E, Fahy JV, Jarjour NN, Kraft M, Lazarus SC, Lemanske RF Jr, Martin RJ, Peters SP, Ramsdell JW, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Wechsler ME. Predicting worsening asthma control following the common cold. Eur Respir J 32 (6):1548-1554, 2008. PubMed PMID: 18768579.

Bacharier LB, Phillips BR, Zeiger RS, Szefler SJ, Martinez FD, Lemanske RF Jr, Sorkness CA, Bloomberg GR, Morgan WJ, Paul IM, Guilbert T, Krawiec M, Covar R, Larson G, Mellon M, Moss MH, Chinchilli VM, Taussig LM, Strunk RC. Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing. J Allergy Clin Immunol 122 (6):1127-1135, 2008. PubMed PMID: 18973936.

Strunk RC, Bacharier LB, Phillips BR, Szefler SJ, Zeiger RS, Chinchilli VM, Martinez FD, Lemanske RF Jr, Taussig LM, Mauger DT, Morgan WJ, Sorkness CA, Paul IM, Guilbert T, Krawiec M, Covar R, Larsen G. Azithromycin or montelukast as inhaled corticosteroid-sparing agents in moderate-to-severe childhood asthma study. J Allergy Clin Immunol 122 (6):1138 1144, 2008.

Bufford, JD, Lemanske RF Jr. Exercise-Induced Asthma. Chaper 40 In: Clinical Asthma, 1st Edition. Castro M, Kraft M, eds. Mosby, Philadelphia, Pennsylvania, 2008. pp. 361-366.


Christine M. Seroogy, MD

Schartner J, Fathman CG, Seroogy CM (2007) Preservation of Self: An Overview of E3 Ubiquitin Ligases and T Cell Tolerance. Seminars in Immunology 19 (3):188-96. PubMed PMID: 17403607.

Jartti T, Burmeister K, Seroogy CM, Jennens-Clough ML, Tisler C, Pleiss L, Evans M, Vrtis R, Wallace P, Ruiz B, Gangnon R, Lemanske RF, and Gern JE (2007) Association between CD4+CD25high T Cells and Atopy in Children. J Allergy Clin Immunol 120 (1):177-83. PubMed PMID: 17433828.

Dahlberg, PE, Schartner, JM, Timmel, A, Seroogy, CM (2007) Daily Subcutaneous Injections of Peptide Induce CD4+ CD25+ T Regulatory Cells. Clinical and Experimental Immunology 149 (2):226-34. PubMed PMID: 17490400.

Shamim M, Nanjappa S, Singh A, Plisch E, LeBlanc S, Walent J, Svaren, Seroogy C, Suresh M (2007) Cbl-b Regulates Antigen-Induced TCR Down-Regulation and IFNg Production by Effector CD8 T Cells without Affecting Functional Avidity. Journal of Immunology 179(11):7233-43.

Christine M. Seroogy (2007). Evaluation, diagnosis, and management of DiGeorge syndrome. UpToDate.

Christine M. Seroogy (2007). Pathogenesis, epidemiology, and clinical manifestations of DiGeorge syndrome, UpToDate. Friedlander S, Dooms K, Voss C, Agger W, Zhang K, Bleesing J, Filipovich A, Seroogy CM (2008) Adolescent Presentation of X-linked Lymphoproliferative Disease. Annals of Allergy, Asthma & Immunology 100(4):398-400. PubMed PMID: 18450131.

Lineberry N, Su L, Lin J, Coffey G, Seroogy CM, Fathman CG (2008) Cutting edge: The Transmembrane E3 Ligase GRAIL Ubiquitinates CD40L During the Induction of T Cell Anergy. Journal of Immunology 181(3):1622-6. PubMed PMID: 18641297.


Judith A. Smith, MD, PhD

JA Smith, MD Barnes, D Hong, ML Delay, RD Inman, RA Colbert. Gene expression analysis of macrophages derived from ankylosing spondylitis patients reveals interferon-gamma dysregulation. Arthritis Rheum 58(6):1640-49, 2008. PubMed PMID: 18512784.

JA Smith, Matthew J. Turner, Dihua Hong, Monica L. Delay, Robert A. Colbert. XBP-1 couples ER stress to the innate immune response by augmenting Toll-like receptor-mediated type I IFN production. Eur J Immunol 38(5):1194-203, 2008. PubMed PMID: 18412159.

Grant Support

James E. Gern, MD

  • NIH/NIAID U19 AI070503-01 (09/01/06-08/31/11)
    “Mechanisms of Rhinovirus-Induced Exacerbations of Asthma”
    Investigates mechanisms by which rhinovirus (RV) infections provoke acute exacerbations of asthma. Project I evaluates genetic polymorphisms associated with more severe RV infections and wheezing in a large clinical population.
    Role: PI
  • NIH/NHLBI P01 HL070831-06A1 (05/01/08-02/28/13)
    “COAST III–Rhinovirus Infection and Childhood Asthma”
    Continues a birth cohort study to determine the interactions and contributions of viral infections and immune development on the pathogenesis of childhood asthma. Identify more virulent strains of rhinoviruses and define molecular mechanisms for increased severity of illness.
    Role: Co-Investigator/ Leader for Project II
  • NIH/NIAID NO1-AI-25496 (09/30/02-09/29/09)
    NIAID Inner City Asthma Consortium: “Immunologic Approaches to Reduced Asthma”
    Multicenter study evaluates the interrelationships between immunologic development and environmental exposures (allergen, stress, viral infections) as related to asthma development in a prospective cohort of inner-city children ages birth to 4.
    Role: Project Leader, Urban Environment and Childhood Asthma (URECA)
  • NIH/NIAID R01 HL080072-01 (09/01/04-05/31/09)
    “T Regulatory Cells and Childhood Asthma”
    Measures the development of TR cells and their relationship to wheezing phenotypes and/or childhood asthma, and helps define how stimulation of the innate immune system relates to maturation of TR cells.
    Role: PI
  • NIH/NIAID T32 AI007635 (09/15/05-08/31/10)
    “Wisconsin Allergy and Immunology Research Training Program”
    Funds a postdoctoral training program for MD and PhD participants in clinical, translational, and basic science research related to allergic diseases and asthma.
    Role: PI

Anna Huttenlocher, MD

  • NIH/NCI R01 CA085862 (06/10/00-05/31/10)
    “Adhesive Regulation During Cell Migration”
    Identify and characterize the molecules that regulate integrin-cytoskeletal interactions during migration.
    Role: PI
  • NIH R01 GM074827 (08/15/05-07/31/09)
    “Neutrophil Chemotaxis in Autoinflammation”
    Study neutrophil chemotaxis defects associated with autoinflammation using in vitro and in vivo approaches in zebrafish. (Renewal uses zebrafish only and has no in vitro work.)
    Role: PI
  • NIH/NIAID R01 AI068062-02 (02/01/07-01/31/11)
    “Regulation of Mast Cell Function by Inhibitory Molecules”
    Understand how the innate immune system contributes to arthritis development in mouse models and what the role is of inhibitory signaling in this regulation.
    Role: PI
  • Burroughs Wellcome Fund (01/15/08-01/14/12)
    “Clinical Scientist Award in Translational Research”
    Patient-based studies investigate leukocyte function in autoinflammatory disease and translation to identify drug targets using zebrafish models.

Robert F. Lemanske, Jr, MD

  • NIH/NHLBI 2 P01 HL070831-06A1 (05/01/08–03/31/13)
    “COAST III–Rhinovirus Infection and Childhood Asthma”
    Evaluate gene by environment interactions, emphasizing rhinovirus infections and their influence on the expression, regression, and progression of childhood asthma.
    Role: PI
  • NIH/NHLBI 5 U10 HL064305 (09/30/99–08/31/10)
    CARE Network–Madison Clinical Center / “Childhood Asthma: Initiation and Intervention”
    A collaborative pediatric asthma research network to encourage and facilitate advancement in the diagnosis, pathogenesis, and treatment of children and adolescents with asthma.
    Role: PI
  • NIH/NHLBI 1 U10 HL074212-01 (09/01/03–07/31/10)
    “ACRN–Treatment of Severe Persistent Asthma”
    Develop an asthma clinical research network for designing protocols to evaluate new drug therapies for asthma.
    Role: PI
  • NIH R01 HL080072 (09/01/04–05/31/10)
    “T Regulatory Cells and Childhood Asthma”
    Measure the development of TR cells and their relationship to wheezing phenotypes and/or childhood asthma, and help define how stimulation of the innate immune system relates to maturation of TR cells.
    Role: Co-investigator

Christine M. Seroogy, MD

  • Midwest Athletes Against Childhood Cancer (04/01/04-03/31/10)
    “The Gene Related to Anergy in Lymphocytes, GRAIL, and its implications in tumor anergy”
    Explore the role an anergy-related gene, GRAIL, in malignancy.
    Role: PI
  • NIH/NHLBI R01 HL80072 (09/01/04-05/31/10)
    “T Regulatory Cells and Childhood Asthma”
    Prospectively study the development and function of CD25+ T regulatory cells in a childhood cohort at increased risk for developing atopic disease.
    Role: Co-PI
  • ART Faculty Development (07/01/07-06/30/10)
    “The Role of Toll-like Receptors (TLRs) in CD25+ T Regulatory Cell Development and Function”
    Characterize the expression of TLRs on naturally occurring and adaptive CD25+ T regulatory cells and investigate the effect of their engagement on CD25+ T regulatory cell biological function.
    Role: PI

Judith A. Smith, MD, PhD

  • UW Institute for Clinical and Translational Research UL1RR025011 (2008)
    “ICTR KL2 Dean’s Scholarship”
    Provides training and protected time to develop an independent research program.
  • UW Division of Biological Sciences Graduate School competition award 090502