Dr. Moreno’s research centers on adolescents’ use of media and technology and how these may impact adolescent health behaviors. Adolescents’ interactions with media and technology have enormous influence on their health and development. Previous studies have shown links between exposure to substance use and sexual content in media, and initiation of these behaviors. Social media are a particular interest of the Adolescent Health Research Team, as these types of media allow adolescents to be both producers and consumers of media messages about health. Learn more...
Dr. Boriosi's area of interest is clinical research, with a goal is to promote and develop clinical research in the PICU. Learn more...
Through clinical studies we have sought to better understand the relationship between obesity/body composition, cardiovascular fitness, and the development of insulin resistance in children. This work began in children with a genetic form of obesity, Prader-Willi syndrome (PWS). Learn more...
The major focus of the Eldridge Laboratory is integrative cardiopulmonary physiology and pathophysiology as it occurs in isolated heart-lung preparations, non-anaesthetized animals and humans, with specific applications to the effects of exercise, acute hypoxia, altitude, hyperbaria and environmental exposure (particulates, endotoxin and ozone). A center focus of our studies is novel regulatory mechanisms of the pulmonary microcirculation and there impact on pulmonary gas exchange. Learn more...
Dr. Farrell has had a long-standing interest in pediatric pulmonology and nutrition, especially as related to infants with respiratory disorders such as cystic fibrosis (CF). His research group for the past 25 years has been focused on CF newborn screening and has been continuously funded by the NIH to investigate the benefits, risks, tests, and costs of early diagnosis through newborn screening for this important genetic disease. Learn more...
Despite decades of research into the pathophysiology of hypoxic-ischemic brain injury and neuroprotection, effective therapy remains elusive and our clinical role after such an injury is largely supportive. More frustrating is the number of promising therapies that are effective in cell culture and animal models, but have subsequently failed to demonstrate benefit in clinical trials. The heterogeneity of injury and physiology, and the uncertain therapeutic window, are barriers to the translation of neuroprotective interventions. Additionally, pediatric brain injury studies must account for age related differences in cerebro-vascular physiology and susceptibility to brain ischemia, requiring prohibitively large multicenter trials to assess clinical benefit. Learn more...
The Gern Laboratory Group is conducting several NIH-funded studies to define the role of viral infections in the initiation and disease activity of asthma, and to identify interactions between host and viral factors that determine the severity of respiratory illnesses. Learn more...
For the past two decades Dr. Giampietro's research interests have been devoted to understanding the genetic basis of scoliosis and congenital vertebral malformations (CVM). Previous funded research in scoliosis has led to the discovery of mutations in PAX1, DLL3 and T(Brachyury) in patients with CVM. Learn more...
Our group’s research goal is to investigate the use of pulse oximetry screening to detect congenital heart disease. This research is important because some babies with significant heart defects will appear to be perfectly well for the first few days after they are born, only to become critically ill within days of going home from the hospital. The use of pulse oximetry screening may help to identify these babies before they get into trouble. Learn more...
Our group focuses on using preclinical mouse models of allogeneic blood and marrow transplant (alloBMT) to cure pediatric leukemias and solid tumors with tumor-directed immunotherapeutic therapies such as dendritic cell vaccines, adoptive NK cell and T cell-based infusions. The goal of this research is to both improve presently used biological therapies in clinical alloBMT, such as donor lymphocyte infusion (DLI), as well as develop novel immune-based therapies that have potential to be translated into the clinic. Learn more...
The increasing burden of fungal disease in the world combined with the emergence of treatment resistant organisms is an alarming challenge to medicine and human health. The Klein laboratory is a molecular medical mycology research group with two broad areas of focus: fungal pathogenesis and immunology. Learn more...
Our lab’s research goals have been to investigate the developmental and nutritional regulation of erythropoiesis (red blood cells production). This research is important because anemia complicates the clinical care of nearly 30,000 premature neonates in US yearly and effective strategies for combating anemia must be developed. Learn more...
Dr. Lemanske's research interests have focused primarily on the pathophysiology and treatment of asthma including mechanisms underlying pulmonary late phase reactions, virus-induced airway dysfunction, and asthma inception in infants and young children. Learn more...
One area of focus for our research team is to investigate the genetic basis of disease in neonates. With the evolution of neonatal health care to address major physiologic contributors to disease, new opportunities are emerging to investigate the influence of genetic mechanisms on neonatal health and to apply new molecular methods in the diagnosis of neonatal disease and its markers. A second major focus has been in the role of dystrophin and its associated proteins in the non-muscle manifestations of Duchenne and other inherited muscular dystrophies. Our particular emphasis has been on neurosensory physiology of both vision and hearing. Learn more...
The Ralphe Laboratory is interested in understanding the impact of metabolism and energy production on cardiac contractile performance in the immature heart. We are particularly focused on understanding how the transitioning perinatal heart responds energetically to the stress of congenital heart disease or other contractile abnormalities. Learn more...
The Seroogy Laboratory has been interested in understanding the immunologic contexts that lead to CD4+ T cell unresponsiveness or anergy. During these investigations, we have found that a major operational mechanism of cellular immune unresponsiveness involves a T cell with suppressive capabilities. This T cell was formally identified in the early 1990s and has been termed a CD25+ T regulatory (Treg) cell. Learn more...
Dr. Sondel's team is pursuing basic, preclinical and clinical mechanisms to induce in vivo activated innate immune effector cells to provide anti-tumor benefit. Learn more...
The focus of the Sorenson Laboratory is to understand the role apoptotic processes play in kidney and vascular development. We have been focusing on the roles of bcl-2 (anti-apoptotic) and bim (pro-apoptotic) members of bcl-2 family play in these processes. The research in this laboratory utilizes transgenic mice, as well as endothelial and nephron specific epithelial cells generated from these mice. Learn more...
The major focus of the Wilhelm lab is the molecular mechanisms underlying learning and memory and how they are perturbed in inherited or congenital brain diseases. We use a variety of in vitro and in vivo tools to study synaptic and dendritic biology to elucidate these mechanisms. The ultimate goal of this research is to improve the neurodevelopmental outcomes of children with both congenital and acquired forms of central nervous system injury. These efforts are imperative because neurodevelopmental disabilities remain the primary negative consequence of critical illness in infants and children despite ever-improving mortality rates for our sickest patients. Learn more...